Edible bird’s nest (EBN) is derived from the saliva of certain types of swiflets. It is consumed in many parts of the world for its nutritional and medicinal values. Although many claims have been made on the therapeutic and health-promoting effects of EBN, scientific documentations regarding these effects are very limited in published literature. It is not until recently that the biological effects of EBN are being investigated and evidence-based studies are being conducted. Several studies have found that EBN may enhance cell proliferation and differentiation and various beneficial effects have been reported in vitro as well as in vivo. While these studies point towards the potential use of EBN in the treatment or even prevention of several diseases, the mechanisms of action of EBN remain largely unknown and more explorations are needed. This review is one of the very few scientific reviews on EBN which focuses on recent evidence-based discoveries.
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Norhayati MK, Azman O, Wan Nazaimoon WM. Preliminary study of the nutritional content of Malaysian edible bird’s nest. Mal J Nutr 2010;16:389–396.
Kong YC, Keung WM, Tip TT, Ko KK, Tsao SW, Ng MH. Evidence that epidermal growth factor is present in Swiflet’s (Collocalia) nest. Comparat Biochem Physiol 1987;87:221–226.
Zhang M, Wang D, Wang J. The effects of the Zhenzhu-Yanwo extracts on animal function. Pharm Biotech 1994;1:49–51.
Guo C, Takahashi T, Bukawa W, Takahashi N, Yagi H, Kato K, et al. Edible bird’s nest extract inhibits influenza virus infection. Antiviral Res 2006;70:140–146.
Tian HH, Ong WS, Tan CL. Nutritional supplement use among university athletes in Singapore. Singapore Med J 2009;50:165–172.
Shih, V, Chiang JYL, Chan A. Complementary and alternative medicine (CAM) usage in Singaporean adult cancer patients. Ann Oncol 2009;20:752–757.
Lim J, Wong M, Chan MY, Rajalingam V, Lim LPN, Lou J, et al. Use of complementary and alternative medicine in pediatric oncology patients in Singapore. Ann Acad Med Singapore 2006;35:753–758.
Hobbs JJ. Problems in the harvest of edible birds’ nests in Sarawak and Sabah Malaysia Borneo. Biodivers Conserv 2004;13:2209–2226.
Price JJ, Johnson KP, Bush SE, Clayton DH. Phylogenetic relationships of the Papuan Swiftlet Aerodramus papuensis and implications for the evolution of avian echolocation. Int J Avian Sci 2005;147:790–796
Lee PLM, Clayton DH, Griffiths R, Page PDM. Does behavior reflect phylogeny in swiftlets (Aves: Apodidae)? A test using cytochrome b mitochondrial DNA sequences. Proc Natl Acad Sci USA 1996;93:7091–7096.
Green JR. The edible bird’s-nest or nest of the Java swift (Collocalia Nidica). J Physiol 1885;6(1–2):40–45.
Marcone MF. Characterization of the edible bird’s nest: the “Caviar of the East”. Food Res Int 2005;38:1125–1134.
Guppy HB. The composition of edible bird’s-nest. Nature 1886;34:100.
Wang CC. The composition of Chinese edible bird’s nests and the nature of their proteins. J Biol Chem 1921;49:429–439.
Yu-Qin Y, Liang X, Hua W, Hui-Xing Z, Xin-Fang Z, Bu-Sen L. Determination of edible bird’s nest and its products by gas chromatography. J Chromatogr Sci 2000;38:27–32.
Dhawan S, Kuhad RC. Effect of amino acids and vitamins on laccase production by the bird’s nest fungus Cyathusbulleri. Bioresource Technol 2002;84:35–38.
Nakagawa H, Hama Y, Sumi T, Li SC, Maskos K, Kalayanamitra K, et al. Occurrence of a nonsulfated chondroitin proteoglycan in the dried saliva of Collocalia swiftlets (edible bird’s-nest). Glycobiology 2007;17:157–164.
Kathan RH, Weeks DI. Structure studies of Collocalia mucoid. Arch Biochem Biophys 1969;134:572–576.
Thong BYH, Cheng YK, Leong KP, Tang CY, Chng HH. Immediate food hypersensitivity among adults attending a clinical immunology/allergy centre in Singapore. Singapore Med J 2007;48:236–240
Hon KLE, Leung TF, Kam WYC, Lam MCA, Fok TF, Ng PC. Dietary restriction and supplementation in children with atopic eczema. Clin Exp Dermatol 2006;31:187–191.
Ng MH, Chan KH, Kong YC. Potentiation of mitogenicity response by extracts of swiftlet’s (Collocalia) nest. Biochem Int 1986;13:521–531
Herbst RS. Review of epidermal growth factor receptor biology. Int J Radiat Oncol Bio Phys 2004;59(2):21–26.
Aswir AR, Wan Nazaimoon WM. Effect of edible bird’s nest on cell proliferation and tumor necrosis factor-alpha (TNF-α) release in vitro. Int Food Res J 2011;18:1123–1127.
Zainal Abidin F, Hui CK, Luan NS, Mohd Ramli ES, Hun LT, Abd Ghafar N. Effects of edible bird’s nest (EBN) on cultured rabbit corneal keratocytes. BMC Complement Altern Med 2011;11:94.
Matsukawa N, Matsumoto M, Bukawa W, Chiji H, Nakayama K, Hara H, et al. Improvement of bone strength and dermal thickness due to dietary edible bird’s nest extract in ovariectomized rats. Biosci Biotechnol Biochem 2011;75:590–592.
Roh KB, Jienny Lee, Kim YS, Park J, Kim JH, Lee J, et al. Mechanisms of edible bird’s nest extract-induced proliferation of human adipose-derived stem cells. Evid Based Complem Alternat Med Available at http://www.hindawi.com/journals/ecam/2012/797520/ Accessed December 22, 2012.
Wong HL, Siu WS, Gao S, Leung PC, Ko CH. Application of Chinese herbal medicines to revitalize adult stem cells for tissue regeneration. Chin J Integr Med 2012;18:903–908.
Sam CT, Tan PH, Lim CH. Establishing the authenticity of edible bird’s nest. ISFM Med Sci Rev 1991;3:1–4.
Huang H, Xi X, Chen W, Chen J. Determination of content of bird nest by spectrophotometer. Guangzhou Food Sci Technol (Chin) 2003;19:68.
Lin JR, Zhou H, Lai XP. Application of stereoscopy on edible birds nest identification. Chin Tradit Herb Drug (Chin) 2006;29:219–221.
Wu YJ, Chen Y, Wang B, Han WR, Ge YQ, Yuan F. Application of SYBRgreen PCR and 2DGE methods to authenticate edible bird’s nest food. Food Res Int 2010;43:2020–2026.
Lin JR, Zhou H, Lai XP, Hou Y, Xian XM, Wang PX, et al. Genetic identification of edible bird’s nest based on mitochondrial DNA sequences. Food Res Int 2009;42:1053–1061.
Zuo Y. Nitrite found in imported edible bird’s nests. People’s Daily. Available at: http://english.peopledaily.com.cn/90882/7689478.html/ Accessed December 18, 2012.
Xin YN, Ni HG, Chen ZY. Semicarbazide in selected bird’s nest products. J Food Prot 2012;75:1645–1649.
Katan MB. Nitrate in foods: harmful or healthy? Am J Clin Nutr 2009;90:11–12.
Griesenbeck JS, Stech MD, Huber JC, Sharkey JR, Rene AA, Brender JD. Development of estimates of dietary nitrates, nitrites, and nitrosamines for use with the short willet food frequency questionnaire. Nutr J 2009;8:6.
But PP, Jiang RW, Shaw PC. Edible bird’s nests-How do the red ones get red? J Ethnopharmacol 2013;145:378–380.
Isa KM. Prevalence of nitrite (NO2) and nitrate (NO3) in edible bird’s nest harvested from swiftlet ranches in the state of Johor. Available at: http://veterinar.johordt.gov.my/laporan_tahunan/prevalen_no2_ebn_johor.pdf/ Accessed December 22, 2012
Food and Safety Division of the Ministry of Health, Malaysia. Standard operating procedure on the control of nitrite level in edible bird’s nest. Available at: http://fsq.moh.gov.my/v3/images/filepicker_users/5ec35272cb-78/Perundangan/Garispanduan/Eks_Sarang_Burung/SOP_EBN_Nitrite-12032012.pdf/ Accessed December 18, 2012
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Wong, R.S.Y. Edible bird’s nest: Food or medicine?. Chin. J. Integr. Med. 19, 643–649 (2013). https://doi.org/10.1007/s11655-013-1563-y
- edible bird’s nest
- nutritional values
- potential health-promoting effects