Abstract
Objective
To review the herbal drugs most often used throughout history for the treatment of osteoporosis; to study their property, flavor and meridian attribution; and to explore their compatibility.
Methods
The “Chinese Medical Classics” (upgrade) CD-ROM was used to retrieve historical prescriptions for the treatment of osteoporosis, and these were collected and sorted. Property, flavor and meridian attribution were determined, and the rules of herbal administration were determined by cluster analysis.
Results
A total of 389 prescriptions were found, involving 238 herbal drugs, with a total frequency of appearance of 4,236. Commonly used medications were Radix Achyranthis Bidentatae, Radix Rehmanniae praeparata, Cortex Cinnamomi, Cortex Eucommiae, Poria, Herba Cistanches, Radix Aconiti lateralis and Radix Angelicae sinensis. The herbs used included five kinds of properties, appearing a total of 2,499 times; the two most common ones were warm and plain. There were seven different drug flavors, occurring 4,151 times; sweet and bitter were the two most common ones. Eight meridian attributions were identified, appearing a total of 6,374 times; Kidney (Shen)-meridian and Liver (Gan)-meridian were the two most common ones. The most common functional categories were yang-tonifying medicinal and blood-tonifying medicinal, and together these accounted for 37.8% of the total. The twenty-eight most commonly used herbal drugs formed 3 prescription clusters: C1: Cortex Eucommiae, Poria, Radix Achyranthis Bidentatae; C2: Cortex Eucommiae, Poria, Radix Achyranthis Bidentatae, Cortex Cinnamomi, Radix Rehmanniae praeparata, Herba Cistanches, Radix Angelicae sinensis, Radix Aconiti lateralis, Semen Cuscutae; C3: Os Tigris, Rhizoma Atractylodes Alba, Radix Moromdae Officinalis, Radix Angelicae pubescentis, Radix Paeoniae Alba, Herba Dendrobii, Rhizoma Alismatis, Fructus Corni, Radix Saposhnikoviae.
Conclusions
Deficiency is the primary pathogenetic factor in osteoporosis, along with “stagnation” and lack of flow of water or blood. Clinical treatment of osteoporosis should be based on Kidney, Liver and Spleen (Pi) supplementation, and complemented by diuresis and dissolution of stasis, while paying attention to adjustment of the spirit.
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References
Zhang H, Zhu HM, Ning XM. Exploration on the cause of disease and pathogenesis of primary osteoporosis. Forum Tradit Chin Med (Chin) 2001;16:24–25.
Wei HW, Du Y, Luo SY, Liu QS. Effect of herb Gukang on preventing and treating bone-loss of ovariectomized rats. Chin J Tradit Med Traumatol Orthop (Chin) 2000;8:19–22.
Lu Y, Gao Z. A study of the law of herbal in treating osteoporosis by traditional Chinese medicine physicians through history using prescription metrology and cluster analysis. Chin J Exp Med Formul (Chin) 2011;17:258–260.
Chinese Pharmacopoeia Commission. Chinese pharmacopoeia. Beijing: Chemical Industry Press; 2005.
Nanjing University of Traditional Chinese Medicine. Chinese herb dictionary. Shanghai: Shanghai Scientific and Technical Publishers; 2001.
Chang WZ, Liu SM, Lu F. Study of correlation between Chinese herb’s nature and its function. Lishizhen Med Mater Res (Chin) 2009;20:633–634.
Chang WZ. Analysis on difficulty of Chinese flavors of property theory. Liaoning J Tradit Chin Med (Chin) 2010;37:42–43.
Gao XM, ed. Traditional Chinese pharmacy. 2nd ed. Beijing: China Press of Traditional Chinese Medicine; 2007:28.
Ding P. Examples of ZHANG Zhong-jing’s formula composition thoughts of constraining mature and remaining function. J Nanyang Institute Tech (Chin) 2009;1:100–103.
Liu JN, Xie M. Connotation of property-removed and actionreserved in medicinal combination. J Beijing Univ Chin Med (Chin) 2011;34:446–447.
Zhao Y, Zhu JP. Study of meridian attribution of Chinese medicine and prescription in Ming Dynasty. J Tradit Chin Med (Chin) 2010;51:563–565.
Li XH, Tian YC, Jie JP. Kidney-deficiency and postmenopausal osteoporosis. China J Basic Med Tradit Chin Med (Chin) 2003;9:80–82.
Pan GC, Wang ZQ, Ju DH. The clinical observation of primary osteoporosis treated with the formula of supplement the Kidney. Chin J Misdiagn (Chin) 2011;1:4048–4049.
Zhang YZ, ed. Gynecology of Chinese medicine. Beijing: China Press of Traditional Chinese Medicine; 2002:168.
Ming Dynasty · Ni ZM, Comment by Zheng JS. Collected works of materia medica. Beijing: Ancient Chinese Medicine Press; 2005:45.
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Supported by Program for Changjiang Scholars and Innovative Research Team in University of Ministry of Education of China (No. IRT0977)
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Gao, Z., Lu, Y., Halmurat·Upur et al. Study of osteoporosis treatment principles used historically by ancient physicians in Chinese Medicine. Chin. J. Integr. Med. 19, 862–868 (2013). https://doi.org/10.1007/s11655-013-1328-z
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DOI: https://doi.org/10.1007/s11655-013-1328-z