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Potential of renal pathology on refining syndrome typing of Chinese medicine in IgA nephropathy

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Abstract

Objective

To investigate the potential of renal pathological index as a differential diagnosis factor for Chinese medicine (CM) syndromes typing in IgA nephropathy (IgAN).

Methods

A total of 1,016 patients with IgAN was recruited from November 2001 to November 2004. All the signs and symptoms including picture of the tongue and pulse tracings were collected. All patients were typed according to the CM syndrome typing scheme for chronic primary glomerulopathy. The severity of glomerulus and tubulointerstitial lesions (mild, moderate-severe) were evaluated using lee’s grading system and the Katafuchi score system.

Results

The syndrome types transform in turn by deficiency of both the Spleen (Pi) and Lung (Fei) qi, deficiency of both qi and yin, deficiency of Liver (Gan) and Kidney (Shen) yin and deficiency of Spleen-Kidney (Shen) yang, with the aggravation of pathogenetic condition and that the manifestation of deficiency of qi clinically showed proliferative lesion of glomerular mesangium, while the glomerular sclerosis pathologically showed the manifestation of yin deficiency.

Conclusion

Renal pathological findings may be a candidate of objective factors to refine CM syndrome typing process.

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Authors and Affiliations

  1. Department of Diagnosis of Chinese Medicine, School of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing, 10029, China

    Jian-jun Li  (李建军)

  2. Institute of Nephrology and Key Laboratory, General Hospital of People’s Liberation Army, Beijing, 100853, China

    Xiang-mei Chen  (陈香美) & Ri-bao Wei  (魏日胞)

Authors
  1. Jian-jun Li  (李建军)
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  2. Xiang-mei Chen  (陈香美)
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  3. Ri-bao Wei  (魏日胞)
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Corresponding author

Correspondence to Jian-jun Li  (李建军).

Additional information

Supported by Fund of Beijing University of Chinese Medicine for Optional Research (No. 2009JYBZZ-XS019)

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Li, Jj., Chen, Xm. & Wei, Rb. Potential of renal pathology on refining syndrome typing of Chinese medicine in IgA nephropathy. Chin. J. Integr. Med. 19, 92–97 (2013). https://doi.org/10.1007/s11655-012-1214-8

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  • DOI: https://doi.org/10.1007/s11655-012-1214-8

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