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The treatment of non-small cell lung cancer by interstitial I-125 seeds implantation combined with chemotherapy and Chinese medicine

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Abstract

Objective

To investigate the effects of brachytherapy with computed tomography-guided percutaneous radioactive I-125 seeds interstitial implantation (ISI) synchronized chemotherapy and Chinese medicine (CM) for the treatment of advanced stage of non-small cell lung cancer (NSCLC).

Methods

Ninety patients diagnosed with NSCLC by biopsy were randomly assigned to three groups: the synchronized therapy group (A), the chemotherapy plus CM-treated group (B), and the chemotherapy-treated group (C); a 2-month course of treatment was administered to them all. The effectiveness of treatment was evaluated based on tumor size, tumor markers (carcinoembryonic, squamous cell carcinoma-associated antigen, and cytokeratin 19 fragment), clinical symptoms, and quality of life (QOL) in patients.

Results

The total effective rates of Groups A to C were 83.33%, 46.67%, and 43.33%, respectively. The tumor markers were reduced obviously in Group A, showing signifificant difference compared with those in the other two groups. Additionally, QOL was elevated and cancer-related symptoms were alleviated more signifificant in Group A than those in Group C (all P<0.05).

Conclusion

The synchronized therapy of I-125 implantation with chemotherapy and CM was a safe therapeutic method and can be regarded as a new mode for treatment of advanced-stage NSCLC.

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Authors and Affiliations

  1. Department of Traditional Chinese Medicine, Chinese People’s Liberation Army General Hospital, Beijing, 100853, China

    Yu Feng  (冯 宇), Shao-dan Li  (李绍旦), Ming-xiong Lin  (林明雄), Yin Zhang  (张 印), Hai-ming Wang  (王海明), Min Li  (李 敏), Ke Cao  (曹 科), Yu-fei Ye  (叶宇飞) & Li Zhao  (赵 丽)

  2. Department of Radiology, Chinese People’s Liberation Army General Hospital, Beijing, 100853, China

    Yue-yong Xiao  (肖越勇) & Xiao Zhang  (张 肖)

Authors
  1. Yu Feng  (冯 宇)
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  2. Yue-yong Xiao  (肖越勇)
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  3. Shao-dan Li  (李绍旦)
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  4. Ming-xiong Lin  (林明雄)
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  5. Yin Zhang  (张 印)
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  6. Hai-ming Wang  (王海明)
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  7. Min Li  (李 敏)
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  8. Xiao Zhang  (张 肖)
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  9. Ke Cao  (曹 科)
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  10. Yu-fei Ye  (叶宇飞)
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  11. Li Zhao  (赵 丽)
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Corresponding author

Correspondence to Yu Feng  (冯 宇).

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Feng, Y., Xiao, Yy., Li, Sd. et al. The treatment of non-small cell lung cancer by interstitial I-125 seeds implantation combined with chemotherapy and Chinese medicine. Chin. J. Integr. Med. 18, 663–669 (2012). https://doi.org/10.1007/s11655-012-1203-y

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  • DOI: https://doi.org/10.1007/s11655-012-1203-y

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