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Logistic regression analysis of damp-heat and cold-damp impeding syndrome of rheumatoid arthritis: A perspective in Chinese medicine

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Abstract

Objective

To investigate a method for quantitative differential diagnosis of damp-heat and cold-damp impeding syndrome of rheumatoid arthritis (RA) in Chinese medicine (CM).

Methods

Laboratory parameters were collected from 306 patients with RA. The clinical symptoms and laboratory parameters were compared between patients with these two syndromes (158 with RA of damp-heat impeding syndrome, and 148 with RA of cold-damp impeding syndrome), and a regression equation was established to facilitate discrimination of the two RA syndromes.

Results

There were significant differences in disease activity score in 28 joints [DAS28 (4)], erythrocyte sedimentation rate (ESR), white blood cell count (WBC), C-reactive protein (CRP), platelet count (PLT), albumin (ALB) and globulin (GLB) between the two syndrome of RA (P<0.05). Logistic regression analysis showed that the parameters ESR, WBC, CRP, joint pyrexia, joint cold, thirst, sweating, aversion to wind and cold, and cold extremities were statistically useful to discriminate damp-heat from cold-damp impeding syndrome. The regression equation was as follows: P=1/{1+exp[-(3.0-0.021X 1-0.196X 2-0.163X 3-1.559X 4+1.504X 5-0.927X 6-1.039X 7+1.070X 8+1.330X 9)]}. The independent variables X 1-X 9 were ESR, WBC, CRP, hot joint, cold joint, thirst, sweating, aversion to wind and cold, and cold limbs. A P value > 0.5 signified cold-damp impeding syndrome, and a P value < 0.5 signified damp-heat impeding syndrome. The accuracy was 90.2%.

Conclusion

The regression equation may be useful for discriminating damp-heat from cold-damp impeding syndrome of RA.

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Authors and Affiliations

  1. Department of Rheumatology, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China

    Zhi-zhong Wang  (王志中), Yong-fei Fang  (方勇飞), Yong Wang  (王 勇), Fang-xiang Mu  (牟方祥), Qing-hua Zou  (邹庆华), Bing Zhong  (钟 兵), Jing-yi Li  (李景怡), Gan-ping Bo  (柏干苹) & Rong-hua Zhang  (张荣华)

  2. Department of Health Statistics, Third Military Medical University, Chongqing, 400038, China

    Jun Chen  (陈 军)

Authors
  1. Zhi-zhong Wang  (王志中)
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  2. Yong-fei Fang  (方勇飞)
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  3. Yong Wang  (王 勇)
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  4. Fang-xiang Mu  (牟方祥)
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  5. Jun Chen  (陈 军)
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  6. Qing-hua Zou  (邹庆华)
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  7. Bing Zhong  (钟 兵)
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  8. Jing-yi Li  (李景怡)
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  9. Gan-ping Bo  (柏干苹)
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  10. Rong-hua Zhang  (张荣华)
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Corresponding author

Correspondence to Yong Wang  (王 勇).

Additional information

supported by the Scientific Program of Traditional Chinese Medicine of Chongqing Municipal Health Bureau, China (2008-1-15) and the National Natural Science Foundation of China (No. 30973827)

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Wang, Zz., Fang, Yf., Wang, Y. et al. Logistic regression analysis of damp-heat and cold-damp impeding syndrome of rheumatoid arthritis: A perspective in Chinese medicine. Chin. J. Integr. Med. 18, 575–581 (2012). https://doi.org/10.1007/s11655-012-1172-1

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  • DOI: https://doi.org/10.1007/s11655-012-1172-1

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