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Clinical study on Tongyan Spray (通咽喷雾剂) for post-stroke dysphagia patients: A randomized controlled trial

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Abstract

Objective

To observe the effectiveness and safety of Tongyan Spray (通咽喷雾剂) composed of Chinese medicine for post-stroke dysphagia patients.

Method

One hundred and twenty-two post-stroke dysphagia patients were randomly assigned to the treatment group (61 cases) and the control group (61 cases). Basic treatment was given to both groups, with Tongyan Spray additionally used in oropharynx for the treatment group, and the placebo used for the control group. After 28-day treatment, the clinical effect and safety were evaluated according to the standard swallowing assessment (SSA) scale.

Results

One patient dropped out in each group, and 120 patients reached the final analysis of the study. The total effective rate for the treatment group was 71.7% (43/60), higher than 46.7% (28/60) in the control group (P<0.05), and the improvement on SSA scores of the two groups were significantly different after treatment (P<0.05). For grade 1 dysphagia patients (completely depending on nasogastric tube), the effective rate of the treatment group was 40.9% (9/22), and 12.5% (2/16) of the control group, without significant difference (P>0.05), while the improvement of SSA score was significantly different between the two groups after treatment (P<0.05). For grade 2–3 dysphagia patients (oral and nasogastric tube feeding), the total effective rate of the treatment group was 89.5% (34/38), higher than 59.1% (26/44) in the control group (P<0.05), and also the improvement on SSA scores was significantly different between the two groups after treatment (P<0.05).

Conclusion

Tongyan Spray was an effective and safe method for post-stroke dysphagia patients.

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Authors and Affiliations

  1. Neurology Department of Beijng Hospital of Traditional Chinese and Western Medicine, Beijing, 100039, China

    Xue-gong Feng  (冯学功), Wen-jie Hao  (郝文杰), Zhou Ding  (丁 舟), Qiang Sui  (隋 强), Huan Guo  (郭 欢) & Jian Fu  (符 健)

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  1. Xue-gong Feng  (冯学功)
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  2. Wen-jie Hao  (郝文杰)
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  3. Zhou Ding  (丁 舟)
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  4. Qiang Sui  (隋 强)
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  5. Huan Guo  (郭 欢)
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  6. Jian Fu  (符 健)
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Corresponding author

Correspondence to Xue-gong Feng  (冯学功).

Additional information

Supported by the Project of Beijing Traditional Chinese Medicine Scientific Program (No.JJ2007-010)

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Feng, Xg., Hao, Wj., Ding, Z. et al. Clinical study on Tongyan Spray (通咽喷雾剂) for post-stroke dysphagia patients: A randomized controlled trial. Chin. J. Integr. Med. 18, 345–349 (2012). https://doi.org/10.1007/s11655-012-1140-9

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  • DOI: https://doi.org/10.1007/s11655-012-1140-9

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