Skip to main content


Log in

A randomized controlled single-blind clinical trial on 84 outpatients with psoriasis vulgaris by auricular therapy combined with optimized Yinxieling Formula (银屑灵优化方)

  • Original Article
  • Published:
Chinese Journal of Integrative Medicine Aims and scope Submit manuscript



To explore the therapeutic effect of auricular therapy combined with optimized Yinxieling Formula (银屑灵优化方) on psoriasis vulgaris.


A randomized controlled single-blind clinical trial on 84 outpatients with psoriasis vulgaris was conducted. The patients were randomized to a treatment group (43 cases treated by auricular therapy combined with optimized Yinxieling Formula) and a control group (41 cases treated by optimized Yinxieling Formula alone) according to a random number generated by SPSS 17.0 software. The treatment duration for both groups was 8 weeks. The therapeutic effect was comprehensively measured by the primary outcome measure [Psoriasis Area and Severity Index (PASI) reduction rate] and the secondary outcome measure [PASI, Visual Analogue Scale (VAS), Dermatology Life Quality Index (DLQI), Self-rating Depression Scale (SDS), and Self-rating Anxiety Scale (SAS)]. The outcomes of both groups were obtained and compared before and after the intervention.


The PASI reduction rate in the treatment group was 74.4% (32/43), which was higher than that in the control group (36.6%, 15/41, P<0.01). The PASI scores decreased in both groups after treatment and was lower in the treatment group compared with the control group P<0.01). With stratified analysis, there were significant differences between the PASI scores in the following subgroups: age 18–30, baseline PASI>10 and stable stage (P<0.05). DLQI decreased in both groups on some categories after treatment, but there were no significant differences between the two groups in SDS, SAS and VAS (P >0.05). No obvious adverse reactions were found in either group.


The therapeutic effect of auricular therapy combined with Optimized Yinxieling Formula was superior to Optimized Yinxieling Formula alone with no obvious adverse reaction.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others


  1. Koo J. Population based epidemiologic study of psoriasis with emphasis on quality of life assessment. Dermatol Clin 1996;14:485–496.

    Article  PubMed  CAS  Google Scholar 

  2. Langley RG, Krueger GG, Griffiths CE. Psoriasis: epidemiology, clinical features, and quality of life. Ann Rheum Dis 2005;64(Suppl) 2:ii18–23.

    Article  PubMed  Google Scholar 

  3. Ding XL, Wang TL, Shen YW, Wang XY, Zhou C, Tian S, et al. Prevalence of psoriasis in China: an epidemiological survey in six provinces. Chin J Dermatol Venereol (Chin) 2010;24:598–601.

    Google Scholar 

  4. Bao LL, Yang XH. The progress of acupuncture on treating psoriasis. Yunnan Chin Med (Chin) 2010;31(2):69–71.

    Google Scholar 

  5. Wang L, Huang YJ, Wang MH. Clinical observation of Yinxieling Formula for the treatment of psoriasis vulgaris. J Guangzhou Univ Tradit Chin Med (Chin) 2009;26:520–525.

    Google Scholar 

  6. Yan YH, Lu CJ. Optimized Yinxieling for treatment of psoriasis vulgaris: an exploratory clinical trial. Tradit Chin Drug Res Clin Pharmacol (Chin) 2011;22:691–693.

    Google Scholar 

  7. Barker R, Kober A, Hoerauf K, Latzke D, Adel S, Kain ZN, et al. Out-of-hospital auricular acupressure in elder patients with hip fracture: a randomized double-blinded trial. Acad Emerg Med 2006;13:19–23.

    Article  PubMed  Google Scholar 

  8. Gates S, Smith LA, Foxcroft DR. Auricular acupuncture for cocaine dependence. Cochrane Database Syst Rev. 2006;25(1):CD005192.

    Google Scholar 

  9. Karst M, Winterhalter M, Münte S, Francki B, Hondronikos A, Eckardt A, et al. Auricular acupuncture for dental anxiety: a randomized controlled trial. Anesth Analg 2007;104:295–300.

    Article  PubMed  Google Scholar 

  10. Liu CF, Yu LF, Lin CH, Lin SC. Effect of auricular pellet acupressure on antioxidative systems in high-risk diabetes mellitus. J Altern Complement Med 2008;14:303–307.

    Article  PubMed  Google Scholar 

  11. Qing H, Tian YS, Fan JM, Tang BY, Niu HQ, Lu JY. Meridian three-combined therapy for treatment of ordinary psoriasis: a multi-center randomized controlled study. Chin Acupunt Moxibust (Chin) 2009;29:181–184.

    Google Scholar 

  12. Psoriasis Group of Dermatology and Venereology, Chinese Medical Association. Clinical guidelines of psoriasis 2008. Chin J Dermatol (Chin) 2009;42:213–214.

    Google Scholar 

  13. Ashcroft DM, Wan Po AL, Williams HC, Griffiths CE. Clinical measures of disease severity and outcome in psoriasis: a critical appraisal of their quality. Br J Dermatol 1999; 141:185–191.

    Article  PubMed  CAS  Google Scholar 

  14. Flytström I, Stenberg B, Svensson A, Bergbrant IM. Methotrexate vs. ciclosporin in psoriasis: effectiveness, quality of life and safety. A randomized controlled trial. Br J Dermatol 2008;158:116–121.

    PubMed  Google Scholar 

  15. Lewis V, Finlay AY. Ten years experience of the Dermatology Life Quality Index (DLQI). J Inv Dermatol Symp Proc 2004; 9:169–180.

    Article  Google Scholar 

  16. White S, Vender R, Thaçi D, Haverkamp C, Naeyaert JM, Foster R, et al. Use of calcipotriene cream (Dovonex cream) following acute treatment of psoriasis vulgaris with the calcipotriene/betamethasone dipropionate two-compound product (Taclonex): a randomized, parallel-group clinical trial. Am J Clin Dermatol 2006;7:177–184.

    Article  PubMed  Google Scholar 

  17. Gina L, Kathy R, Gail S. Alefacept for chronic plaque psoriasis: a selective therapy: clinical efficacy of alefacept. dermatol nurs. 2003;15(3):7–12.

    Google Scholar 

  18. Asher GN, Jonas DE, Coeytaux RR, Reilly AC, Loh YL, Motsinger-Reif AA, Winham SJ. Auriculotherapy for pain management: a systematic review and meta-analysis of randomized controlled trials. J Altern Complement Med 2010;10:1097–1108.

    Article  Google Scholar 

  19. Ma XP. Auricular cutting combined with acupuncture treat 115 patients of psoriasis. Chin Acupunct Moxibust (Chin) 2004;24:254.

    Google Scholar 

  20. Zhang CS, Yang AW, Zhang AL, Fu WB, Thien FU, Lewith G, et al. Ear-acupressure for allergic rhinitis: a systematic review. Clin Otolaryngol 2010;35:6–12.

    Article  PubMed  Google Scholar 

  21. Yeh ML, Tsou MY, Lee BY, Chen HH, Chung YC. Effects of auricular acupressure on pain reduction in patient-controlled analgesia after lumbar spine surgery. Acta Anaesthesiol Taiwan 2010;48(2):80–86.

    Article  PubMed  Google Scholar 

  22. Nixon SA, Baetz J. Review of bloodletting and miraculous cures by Vincent Lam. Philosophy Ethics Humanities Med 2007;2:14.

    Article  Google Scholar 

  23. Zhang H, Gu J. Progress of experimental study on treatment of psoriasis by Chinese medicinal monomer and single or compound recipe in Chinese materia medica. Chin J Integr Med 2007;13:312–316.

    Article  PubMed  Google Scholar 

  24. Xu LP, Bao DH. Therapeutic effect of treating psoriasis by “cutting therapy” at the eardrum. Acta Acad Med CPAPF (Chin) 2006;15:474.

    Google Scholar 

  25. Yin GZ, Zhen LJ. Clinical observation and nursing care of venesection blood letting on treating 72 cases of blood-heat psoriasis. Xinjiang Chin Med (Chin) 2009;27(5):13–15.

    Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Chuan-jian Lu  (卢传坚).

Additional information

Supported by the Financial Industry Technology Research and Development Program of Guangdong Province (No. 201105)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lu, Cj., Xiang, Y., Xie, Xl. et al. A randomized controlled single-blind clinical trial on 84 outpatients with psoriasis vulgaris by auricular therapy combined with optimized Yinxieling Formula (银屑灵优化方). Chin. J. Integr. Med. 18, 186–191 (2012).

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: