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Clinical study on treatment of infantile cytomegalovirus hepatitis with integrated Chinese and Western medicine

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Abstract

Objective

To evaluate the efficacy and safety of Chinese medicine (CM) in treating infantile cytomegalovirus hepatitis (ICH).

Methods

A total of 100 infant ICH patients were randomly assigned to two groups, 60 in the treatment group and 40 in the control group. Ganciclovir was administered to all patients via intravenous dripping at dose of 5 mg/kg every 12 h for 2 weeks, followed by 5 mg/kg once a day for 5 days every week; the whole treatment course lasted 8 weeks. Besides, the patients in the treatment group were treated with CM of Qinggan Lidan Decoction (清肝利胆汤, QLD) during icteric stage, and Yigan Jiangmei Decoction (益肝降酶汤, YJD) in non-icteric hyper-aminotransferase stage by oral medication, while for those in the control group, glucurolactone 50 mg was given three times per day. The efficacy of treatment was evaluated at the ends of 2nd, 4th and 8th weeks, respectively. And a follow-up study was carried out for 6–24 months.

Results

The total effective rate was 95.0% (57/60) in the treatment group and 77.5% (31/40) in the control group; the overall curative effect in the former was superior to that in the later, showing a significant difference (P=0.021). Cholestasis and liver function were improved in both groups, and the effect of reducing serum bilirubin level in the treatment group was more rapid and extensive than that in the control group, which could reduce the post-hepatitis cirrhotic risk caused by long-term cholestasis and liver cell damage.

Conclusion

The therapeutic efficacy of integrated CM and Western medical drug therapy, by using QLD during icteric stage and YJD in nonicteric hyper-aminotransferase stage, was significantly higher than that of routine Western medical treatment alone; it was an ideal project for the treatment of infantile cytomegalovirus hepatitis.

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Author information

Authors and Affiliations

  1. Department of Chinese Medicine, Beijing Children’s Hospital Affiliated to Capital University of Medical Sciences, Beijing, 100045, China

    Yan Hu  (胡 艳), Li Chen  (陈 黎), Jing Shu  (舒 静), Yuan Yao  (幺 远) & Hui-min Yan  (闫惠敏)

Authors
  1. Yan Hu  (胡 艳)
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  2. Li Chen  (陈 黎)
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  3. Jing Shu  (舒 静)
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  4. Yuan Yao  (幺 远)
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  5. Hui-min Yan  (闫惠敏)
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Corresponding author

Correspondence to Hui-min Yan  (闫惠敏).

Additional information

Supported by the Funds of Capital Medicine Development Program (No. 2005-SF-III-036)

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Hu, Y., Chen, L., Shu, J. et al. Clinical study on treatment of infantile cytomegalovirus hepatitis with integrated Chinese and Western medicine. Chin. J. Integr. Med. 18, 100–105 (2012). https://doi.org/10.1007/s11655-012-0992-3

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  • DOI: https://doi.org/10.1007/s11655-012-0992-3

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