A randomized double-blind placebo-controlled study of Pu’er tea (普洱茶) extract on the regulation of metabolic syndrome

Abstract

Objective

To explore the regulative efficacy of Pu’er tea (普洱茶) extract on metabolic syndrome.

Methods

Ninety patients with metabolic syndrome were randomly divided into two groups, the intervention group administered with Pu’er tea extract, and the placebo group with placebo capsules. After 3 months’ treatment, body mass index, waist hip ratio, blood lipids, blood sugar, immune and inflammatory index, and oxidation index of the patients with metabolic syndrome were tested and analyzed.

Results

In the intervention group, the body mass index, waist-hip ratio, fasting and 2 h postprandial blood glucose, serum total cholesterol, triglycerides, low density lipoprotein and apolipoprotein B-100 all decreased in the patients with metabolic syndrome, and also the high-density lipoprotein level increased and apolipoprotein A-1 showed the tendency to increase. Serum C-reactive protein, tumor necrosis factor-α, and interleukin-6 were decreased in the intervention group. Interleukin-10 level was increased, MDA was decreased and superoxide dismutase was increased. Compared with before treatment and the placebo group, there were significant differences (P<0.05, P<0.01).

Conclusions

Pu’er tea demonstrated excellent potential in improving central obesity, adjusting blood lipid, lowering blood sugar, regulating immunity and resisting oxidation. It can adjust the metabolic syndrome of different clinical phenotypes to different degrees, and is ideally fit for early prevention of metabolic syndrome.

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References

  1. 1.

    Wang PS, Liang MZ. Foretime and now of Pu’er tea. Tropical Agricultural Sci Technol (Chin) 2001;24(4):23–27.

    Google Scholar 

  2. 2.

    Metabolic Syndrome Study Group of Diabetes Branch of Chinese Medical Association. Recommendations on the metabolic syndrome of Diabetes Branch of Chinese Medical Association. Chin J Diabetes (Chin) 2004;12:156–160.

    Google Scholar 

  3. 3.

    Eckle RH, Grundy SM, Zimmet PZ. The metabolism syndrome. Lancet 2005;365:1415–1428.

    Article  Google Scholar 

  4. 4.

    Gu D, Reynolds K, Wu X, Chen J, Duan X, Reynolds RF, et al. Prevalence of the metabolism syndrome and overweight among adult in China. Lancet 2005;365:1398–1405.

    PubMed  Article  Google Scholar 

  5. 5.

    Xiao YX. Recognition and therapeutic thoughts on metabolism syndrome. Chin J Basic Med Tradit Chin Med (Chin) 2007;13:538–539.

    Google Scholar 

  6. 6.

    Li XJ, Liu ZL. Discussion on treatment of metabolism syndrome from spleen. Guiding J Tradit Chin Med Pharmacol (Chin) 2006;12(4): 9–10.

    Google Scholar 

  7. 7.

    Yuan HB, Zhong J, Yi J, Zhao Y, Cao J. Tea extract on diet-induced obese rats lipogenic gene expression. Acta Nutrimenta Sin (Chin) 2009;31:167–171.

    CAS  Google Scholar 

  8. 8.

    Jiang XF, Shao WF, Hou Y. Study on the function of preventing the hyperlipidemia lipid level and the antioxidant of the Pu’er tea. J Yunnan Agricultural Univ (Chin) 2009;24:705–711.

    Google Scholar 

  9. 9.

    Zhou BX, Kong LB, Chen JX. Study on extraction of Pu’er tea polysaccharides and hypoglycemic. Chin Agricultural Sci Bull (Chin) 2009;25(15):55–59.

    Google Scholar 

  10. 10.

    Wellen KE, Hotamisliglil GS. Obesity-induced inflammatory changes in adipose tissue. J Clin Invest 2003;112:1785–1788.

    PubMed  CAS  Google Scholar 

  11. 11.

    Cardoso-Saldaña G, Juárez-Rojas JG, Zamora-González J, Raygoza-Pérez M, Martinez-Alvarado R, Posadas-Sánchez R, et al C-reactive protein levels and their relationship with metabolic syndrome and insulin resistance in Mexican adolescents. J Pediatr Endocrinol Metab 2007;20:797–805.

    PubMed  Article  Google Scholar 

  12. 12.

    Kraja AT, Province MA, Arnett D, Wagenknecht L, Tang WH, Hopkins PN, et al. Do inflammation and procoagulation biomarkers contribute to the metabolic syndrome cluster. Nutr Metab (Lond) 2007;4:28.

    Article  Google Scholar 

  13. 13.

    Ferrari R, Ceconi C, Curello S, Cargnoni A, Alfieri O, Pardini A, et al. Oxygen free radicals and myocardial damage: protective role of thiol-containing agents. Am J Med 1991;91(3C):95S–105S.

    Article  Google Scholar 

  14. 14.

    Hatori N, Sjöquist PO, Marklund SL, Pehrsson SK, Rydén L. Effects of recombinant human extracellular-superoxide dismutase type C on myocardial reperfusion injury in isolated cold-arrested rat hearts. Free Radic Biol Med 1992;13:137–142.

    PubMed  Article  CAS  Google Scholar 

  15. 15.

    Lee KU. Oxidative stress markers in Korean subjects with insulin resistance syndrome. Diabetes Res Clin Pract 2001; 54(Suppl 2):S29–S33.

    PubMed  Article  CAS  Google Scholar 

  16. 16.

    Yang AF, Liu MY, Wang CQ, Ding HY, Xie XL, Xu YM, et al. Metabolic syndrome patients with oxidation — index changes of platelet aggregation. J Cardiovas Pulmonary Dis (Chin) 2004;23:228–230.

    Google Scholar 

Download references

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Correspondence to Xue-mei Wang 王学美.

Additional information

Supported by the Major Project of Development of Biotic Resources in Yunnan Province (No. 2007YNCXB-01-01)

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Chu, S., Fu, H., Yang, J. et al. A randomized double-blind placebo-controlled study of Pu’er tea (普洱茶) extract on the regulation of metabolic syndrome. Chin. J. Integr. Med. 17, 492–498 (2011). https://doi.org/10.1007/s11655-011-0781-4

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Keywords

  • tea
  • metabolic syndrome
  • randomized controlled clinical study