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Thinking path and method for establishing the disease/Chinese medicine syndrome conjugated pattern of a mammary hyperplasia animal model

  • Thinking and Methodology
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Abstract

Mammary hyperplasia (MHP) is the most commonly encountered mammary disease in women at the child-bearing stage. Especially, atypical hyperplasia which belongs to the precancerous category, is the disease for class I prevention of breast cancer. Therefore, advancing the clinical efficacy of MHP treatment is of critical importance. Chinese medicine (CM) and drugs show a peculiar effect in this field; the clinical or experimental researches concerning MHP treatment by CM compounds or patent drugs have been increasing gradually in recent years, but the thinking paths and methods for establishing the MHP animal model are divergent. Particularly, the disease/CM syndrome conjugated model (D/S model) has rarely been studied. For this reason, the pathogenetic mechanism, the establishment of an animal disease model, as well as the thinking paths and methods for establishing the D/S model of MHP are discussed and summarized preliminarily in this paper by the authors. This could provide a new way of thinking and method for creating the MHP model in modern medicine.

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Authors and Affiliations

  1. Medical College of Jinan University, Guangzhou, 510632, China

    Min Ma  (马 民) & He-ning Zhai  (翟贺宁)

Authors
  1. Min Ma  (马 民)
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  2. He-ning Zhai  (翟贺宁)
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Corresponding author

Correspondence to Min Ma  (马 民).

Additional information

Supported by Guangdong Provincial Key Projects of Sciences and Technology (No. 2009B030801238, 2006B35602009); Guangdong Provincial Administration of Traditional Chinese Medicine (No. 1060114, 2008092); The Planned Science and Technology Project of Guangzhou (No. 2009Z1-E091)

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Ma, M., Zhai, Hn. Thinking path and method for establishing the disease/Chinese medicine syndrome conjugated pattern of a mammary hyperplasia animal model. Chin. J. Integr. Med. 16, 457–463 (2010). https://doi.org/10.1007/s11655-010-9996-z

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  • DOI: https://doi.org/10.1007/s11655-010-9996-z

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