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Chinese Journal of Integrative Medicine

, Volume 15, Issue 6, pp 448–453 | Cite as

Effect of Chlorophytum Borivilianum Santapau and Fernandes on sexual dysfunction in hyperglycemic male rats

  • Mayank ThakurEmail author
  • Shilpi Bhargava
  • Werner Praznik
  • Renate Loeppert
  • Vinod K. Dixit
Experimental Research

Abstract

Objective

To investigate the effects of Chlorophytum borivilianum (CB) on sexual dysfunction, loss of body weight, and lack of libido in hyperglycemic rats induced with streptozotocin or alloxan.

Methods

Wistar strain male albino rats were divided into five groups of six animals each: the control group (2% polyvinylpyrollidone solution), the streptozotocin control group (50 mg/kg), the alloxan control group (100 mg/kg), the streptozotocin + CB treated group (200 mg/kg), and the alloxan + CB treated group (200 mg/kg). Only after confirming the induction of diabetes, the animals of test groups were treated with CB. The sexual behavior of male rats of in presence of female rat in a special cage was recorded. The effects of induced diabetes in control groups and on simultaneous extract treatment in CB treated groups were tested for sexual parameters. The parameters evaluated included mount, ejaculation, and intromission latencies/frequencies, hesitation time, and penile erection index. Parallel to this, using a separate set of similarly treated animals, the influence of diabetes and CB treatment on anabolism and weight of secondary sexual organs were determined on day 0 and day 28 of the treatment.

Results

CB extract treatment ameliorated the diabetes-induced dysfunction at 200 mg/kg dose. There was very low weight loss (P<0.05) in CB-treated animals as compared to the diabetic control. There was a very high latency time (P<0.05) in the diabetic animals, whereas the latency time was very low in CB-treated animals. Mount, intromission, and ejaculation frequencies were very high (P<0.01) in CB-treated animals, while streptozotocin and alloxan groups animals had a very significantly lower sexual behavior (P<0.05) compared to the normo-glycemic control group animals.

Conclusion

CB can significantly ameliorate diabetes-induced sexual dysfunction. Polysaccharide and saponin-rich aqueous extract appears to have the most suitable effects on diabetes and its associated effects on sexual functionality.

Key Words

ayurvedic rasayana Chlorophytum borivilianum diabetes induced sexual dysfunction Safed Musli 

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Copyright information

© Chinese Association of the Integration of Traditional and Western Medicine and Springer Berlin Heidelberg 2009

Authors and Affiliations

  • Mayank Thakur
    • 1
    • 2
    Email author
  • Shilpi Bhargava
    • 1
  • Werner Praznik
    • 2
  • Renate Loeppert
  • Vinod K. Dixit
    • 1
  1. 1.Department of Pharmaceutical SciencesDr. Hari Singh Gour UniversitySagar, Madhya PradeshIndia
  2. 2.Department of ChemistryUniversity of Natural and Applied Life SciencesViennaAustria

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