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Chinese Journal of Integrative Medicine

, Volume 15, Issue 6, pp 431–434 | Cite as

Clinical study on treatment of hyperuricaemia by retention enema of Chinese herbal medicine combined with allopurinol

  • Qian Chen (陈 茜)
  • Li Ma (马 丽)
  • Wupu Akebaier (阿克拜尔·乌普)
Original Article

Abstract

Objective

To study the effect of retention enema of Chinese herbal medicine combined with allopurinol in treating hyperuricaemia (HUE).

Methods

Seventy-eight patients with HUE were assigned to two: groups, the 40 patients in the treated group were treated with retention enema of Chinese herbal medicine combined with oral intake of allopurinol, and the 38 patients in the control group were treated with allopurinol alone. The therapeutic course for all was 6 weeks. The clinical efficacy, changes of symptoms, blood levels of uric acid and lipids, renal function, and 24 h urinary micro-albumin were observed.

Results

The total effective rate was: 92.5% in the treated group, which was significantly higher than that in the control group (68.4%, P<0.05). After treatment, the score of symptoms in the treated group decreased from 9.43±1.15 scores to 3.25±0.85 scores, significantly lower than that in the control group (9.75±1.43 scores vs 9.25±0.82 scores, P<0.01). Moreover, the post-treatment improvements in blood uric acid, blood lipids, renal function and 24h urinary micro-albumin in the treated group were all better than those in the control group (P<0.05 or P<0.01).

Conclusion

Retention enema with: Chinese herbal medicine combined with allopurinol could obviously reduce the uric acid level in blood, improve patients’ renal function and lipid metabolism, and alleviate the clinical symptoms in patients with HUE.

Key Words

Chinese herbal medicine retention enema hyperuricaemia 

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References

  1. 1.
    Carnethon MR, Fortmann SP, Palaniappan L. Risk factors for progression to incident hyperinsulinemia: the atherosclerosis risk in communities study, 1987–1998. Am J Epidemiol 2003 158:1058.CrossRefPubMedGoogle Scholar
  2. 2.
    Campo C, Garcia PJ. Relationship between severity of essential arterial hypertension and the prevalence hyperuricemia. Med Clin ( Barc) 2001;117:93.Google Scholar
  3. 3.
    Johnson RJ, Kivlighn SD, Kim YG, Suga S, Fogo AB. Reappraisal of the pathogenesis and consequences of hyperuricemia in hepertension, cardiovascular diease, and renal diease. Am J Kidney Dis 1999;33:225–234.CrossRefPubMedGoogle Scholar
  4. 4.
    Chen GL, XU SY. The progress of study on hyperuricemia. Chin Pharmacol Bull (Chin) 2003,19:1008–1012.Google Scholar
  5. 5.
    Wu HM, Liu R. Clinical analysis on 54 patients with type 2 diabetes and hyperuricemia. J Chin Phys (Chin) 2006;8:115–116.Google Scholar
  6. 6.
    Liao EY, Mo CH, eds. Endocrinology. Beijing: People’s Medical Publishing House; 2002:2008–2009.Google Scholar
  7. 7.
    Zheng XY, ed. Guiding Pinciple of clinical research on new drugs of traditional Chinese Medicine. Beijing: China Medicpharmaceutical Science and Technology Publishing House; 2002: 156–162.Google Scholar
  8. 8.
    Alex M. Darison, J. Stewart Cameron, Jean-Pierre Grunfeld, eds. Oxford textbok of clinical nephrology. New York: Oxford Univesity Press; 1992:825–837Google Scholar
  9. 9.
    Yu JY, Xiong NN, Liu F, Zou JD, Huang LJ, Ye LF, et al. Clinical trial of cortex fraxini total coumarin in treating primary hyperuricaemia. Chin J Clin Pharmacol (Chin) 2008;24:3–5.Google Scholar
  10. 10.
    Shen YJ. Pharmacology of Chinese materia medica. Beijing: People’s Medicial Publishing House; 2000:438.Google Scholar
  11. 11.
    Ning YY, Wang JQ, Qu SL. Effect of emodin on human kidney fibroblast proliferation. Chin J Integr Tradit West Med (Chin) 2000;20:105.Google Scholar
  12. 12.
    Xu ZC, Li XM, Ling YF, Shen MZ, Xiong YK. Effect of Injection Salvia mlltiorrhizae on peritoneal dialysis. Chin J Integr Tradit West Med (Chin) 1993;13:74–76.Google Scholar
  13. 13.
    Zhao RL. Progress on clinical study of Chinese medicine. Beijing: Beijing Publishing House; 2000:172,727.Google Scholar

Copyright information

© Chinese Association of the Integration of Traditional and Western Medicine and Springer Berlin Heidelberg 2009

Authors and Affiliations

  • Qian Chen (陈 茜)
    • 1
  • Li Ma (马 丽)
    • 1
  • Wupu Akebaier (阿克拜尔·乌普)
    • 1
  1. 1.Department of EndocrinologyTraditional Chinese Medcine Hospital of Xinjiang Uigur MunicipalityUrumqiChina

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