Abstract
Objective
To evaluate the clinical therapeutic effects of oral administration and external application of Chinese drugs combined with micro-invasive surgery for the treatment of varicose ulcers in the lower extremities (ecthyma).
Methods
A total of 152 patients (163 limbs) suffering from varicose ulcers on the lower limbs were assigned to two groups according to the patients’ willingness. The 102 cases (109 limbs) in the treatment group underwent the method of endovenous microwave closure of communicating veins combined with oral administration and external application of Chinese drugs before and after the operation. The 50 cases (54 limbs) in the control group, were treated with oral administration and external application of Chinese drugs only. Clinical manifestations, including the condition of ulcer healing, the improvement conditions of alogotrophy, edema and other symptoms, were observed before and after 3 months of treatment. The clinical healing rate, the ulcer healing time, and the ulcer recurrence rate, were compared between the two groups. All the patients were followed-up 3 months after treatment.
Results
The follow-up was carried out for 3 to 42 months (mean 30.5 months). In the treatment group, 99 patients (106 limbs) were clinically cured, and the clinical healing rate was 97.06%; the ulcer healing time was 9–101 days (average 31.25±8.28 days) and 3 cases (5 limbs) had recurrence; the ulcer recurrence rate was 5.81%. In the control group, 40 patients (43 limbs) were clinically cured, with a clinical healing rate of 80.00%; the ulcer healing time was 10–152 days (average 50.60±12.31 day) and 5 cases (7 limbs) recurred, with the ulcer recurrence rate being 20.59%. The effects in the treatment group were obviously better than those in the control group (P<0.01 or P<0.05).
Conclusion
The oral administration and external application of Chinese drugs combined with micro-invasive surgery for the treatment of varicose ulcers in the lower extremities has a significant curative effect, with a higher clinical healing rate, shorter ulcer healing time and lower ulcer recurrence rate than either treatment alone.
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References
Duan ZQ, ed. Surgery. Beijing: People’s Medical Publishing House; 2001:410–413.
State Administration of Traditional Chinese Medicine, P. R. China. Standard for diagnosis and efficacy evaluation of traditional Chinese medicine diseases and syndromes. Nanjing: Nanjing University Press; 1994:32–34.
Perrin MR, Guex JJ, Euckley CV, dePalma RG, Royle JP, et al. Recurrent varices after surgery (REVAS), a consensus document. REVAS group. Cardiovasc Surg 2000;8: 233–245.
Ye XC, ed. Chinese materia medica. 2nd ed. Shanghai: Shanghai College of Traditional Chinese Medicine Publishing House; 1988:783.
State Administration of Traditional Chinese Medicine, P. R. China. Standard for diagnosis and curative efficacy evaluation of surgical disease of traditional Chinese medicine. Traditional Chinese medicine professional standard of the People’s Republic of China: 1995:50–51.
Chant A. The biomechanics of leg ulceration. Ann R Coll Surg Engl 1999;81:80–85.
Coleridge Smith PD. Deleterious effects of white cells in the course of skin damage in CVI. Int Angiol 2002;21(2 Suppl 1):26–32.
Lei ZQ, ed. Chinese materia medica. Shanghai: Shanghai Scientific and Technical Publishers; 1995:62–65, 69–70.
Shen YJ, ed. Pharmacology of Chinese materia medica. Beijing: People’s Medical Publishing House; 2002:918–920.
Wang XP, Su WJ, Wang SS, Song W, Wang Q, Zhang Y. Microwave intracavitary minimally invasive treatment of varicose veins in lower extremities. Chin J Gen Sur (Chin) 2006;15:938–940.
Wang XP, Su WJ, Song W, Wang Q, Zhang Y, Wang SS. Microwave intracavitary coagulation and sclerosant injection in the treatment of varicose veins in lower extremities. J Clin Sur (Chin) 2006;5:286–288.
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Supported by the Funds of Shanghai Health Bureau (No. 2007156)
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Wang, Xp., Zhang, Y., Su, Wj. et al. Oral administration and external application of Chinese drugs combined with micro-invasive operation for the treatment of varicose ulcers in the lower extremities. Chin. J. Integr. Med. 15, 420–425 (2009). https://doi.org/10.1007/s11655-009-0420-5
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DOI: https://doi.org/10.1007/s11655-009-0420-5