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Effect of Qiming Granule (芪明颗粒) on retinal blood circulation of diabetic retinopathy: A multicenter clinical trial

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Abstract

Objective

To objectively assess the effect of Qiming Granule (芪明颗粒) in the treatment of diabetic retinopathy (DR) by fluorescence fundus angiography (FFA).

Methods

In a multi-center, randomized, parallel controlled clinical trial, patients with DR were randomly assigned to the control group (calcium dobesilate capsule) and the test group (Qiming Granule). Changes in the retinal blood circulation time were recorded by FFA after 3 months of medication.

Results

Significant reduction was observed in the retinal arterio-venous circulation time (AVCT) in both groups (P<0.01), the value was 7.635±3.149 s before treatment and 5.165 ±3.382 s after treatment in the treated group, and 7.737±3.413 s and 5.313±3.472 s in the control group respectively. Qiming Granule also reduced the arm-to-retinal circulation time (ARCT, P<0.05). The value was 17.867±3.872 s before treatment and 15.643±4.648 s after treatment in the treated group, and 17.217±3.833 s and 16.312±3.613 s in the control group (P>0.05) respectively. The ARCT in the tested group was reduced, with a statistically significant difference post-medication (P<0.01).

Conclusion

As a Chinese medicine complex prescription, Qiming Granule may alleviate retinal hypoxia and ischemia by increasing retinal blood flow and improving the blood circulation.

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Author information

Author notes

  1. Xiang-xia Luo  (罗向霞)

    Present address: Department of Ophthalmology, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou, 730050, China

Authors and Affiliations

  1. Department of Ophthalmology, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China

    Xiang-xia Luo  (罗向霞), Jun-guo Duan  (段俊国) & Pin-zheng Liao  (廖品正)

  2. Guang’ anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China

    Lie Wu  (吴 烈)

  3. The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, 510405, China

    Yang-gui Yu  (余扬桂)

  4. Guangdong Hospital of Traditional Chinese Medicine, Guangzhou, 510220, China

    Bo Qiu  (邱 波)

  5. Jiangsu Hospital of Traditional Chinese Medicine, Nanjing, 210029, China

    Yu-liang Wang  (王育良)

  6. The First Affiliated Hospital of College of Medicine, Zhejiang University, Hangzhou, 310003, China

    Yu-min Li  (李毓敏)

  7. Southwest Hospital, Chongqing, 400038, China

    Zheng-qin Yin  (阴正勤)

  8. Hospital of Optometry and Ophthalmology, Wenzhou Medical College, Zhejiang Province, 325027, China

    Xiao-ling Liu  (刘晓玲)

  9. The Second Affiliated Hospital of College of Medicine, Zhejiang University, Hangzhou, 310009, China

    Ke Yao  (姚 克)

Authors
  1. Xiang-xia Luo  (罗向霞)
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  2. Jun-guo Duan  (段俊国)
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  3. Pin-zheng Liao  (廖品正)
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  4. Lie Wu  (吴 烈)
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  5. Yang-gui Yu  (余扬桂)
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  6. Bo Qiu  (邱 波)
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  7. Yu-liang Wang  (王育良)
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  8. Yu-min Li  (李毓敏)
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  9. Zheng-qin Yin  (阴正勤)
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  10. Xiao-ling Liu  (刘晓玲)
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  11. Ke Yao  (姚 克)
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Corresponding author

Correspondence to Jun-guo Duan  (段俊国).

Additional information

Supported by the National Key Technologies R&D Programme for the 10th Five-year Plan (No. 2001BA701A13a)

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Luo, Xx., Duan, Jg., Liao, Pz. et al. Effect of Qiming Granule (芪明颗粒) on retinal blood circulation of diabetic retinopathy: A multicenter clinical trial. Chin. J. Integr. Med. 15, 384–388 (2009). https://doi.org/10.1007/s11655-009-0384-5

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  • DOI: https://doi.org/10.1007/s11655-009-0384-5

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