Dietary supplement with a combination of Rhodiola crenulata and Ginkgo biloba enhances the endurance performance in healthy volunteers

Abstract

Objective

To determine whether the ingestion of a herbal supplement called Rhodiola-Gingko Capsule (RGC) would enhance the endurance performance of healthy volunteers and change relevant hormones in a favorable manner.

Methods

Seventy healthy male volunteers (age ranges from 18 to 22 years old) were randomly assigned to RGC group (35 cases, each capsule containing 270 mg herbal extracts, 4 capsules per day) or placebo group (35 cases, equivalent placebo preparation) for 7 weeks using computerproduced digital random method. The endurance performance, serum testosterone and cortisol levels were measured at the baseline and the endpoint.

Results

Sixty-seven subjects (34 in the RGC group and 33 in the placebo group) completed a 7-week treatment. The RGC group displayed a significantly greater baseline-toendpoint increase in maximal oxygen uptake (VO2max) than placebo group in both absolute (P=0.020) and relative values (P=0.023). At the endpoint, the serum cortisol level was unchanged in the RGC group compared with the baseline, but it was significantly elevated in the placebo group (P<0.05). The endpoint ratio of testosterone to cortisol, a surrogate for overtraining and fatigue in endurance exercises, was also indifferent compared with the baseline in the RGC group, but significantly decreased in the placebo group (P<0.05).

Conclusion

The combined herbal supplement of Rhodiola and Gingko could improve the endurance performance by increasing oxygen consumption and protecting against fatigue.

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References

  1. 1.

    Bucci LR. Selected herbals and human exercise performance. Am J Clin Nutr 2000;72:624S–36S.

    PubMed  CAS  Google Scholar 

  2. 2.

    Rosenfield C. The use of ergogenic agents in high school athletes. J Sch Nurs 2005;21:333–339.

    PubMed  Article  Google Scholar 

  3. 3.

    Birks J, Grimley Evans J. Ginkgo biloba for cognitive impairment and dementia. Cochrane Database Syst Rev 2007;18:CD003120.

    Google Scholar 

  4. 4.

    Kelly GS. Rhodiola rosea: a possible plant adaptogen. Altern Med Rev 2001;6:293–302.

    PubMed  CAS  Google Scholar 

  5. 5.

    Walker TB, Robergs RA. Does Rhodiola rosea possess ergogenic properties? Int J Sport Nutr Exerc Metab 2006;16:305–315.

    PubMed  CAS  Google Scholar 

  6. 6.

    Ming DS, Hillhouse BJ, Guns ES, Eberding A, Xie S, Vimalanathan S, et al. Bioactive compounds from Rhodiola rosea (Crassulaceae). Phytother Res 2005;19:740–743.

    PubMed  Article  CAS  Google Scholar 

  7. 7.

    Rege NN, Thatte UM, Dahanukar SA. Adaptogenic properties of six rasayana herbs used in Ayurvedic medicine. Phytother Res 1999;13:275–291.

    PubMed  Article  CAS  Google Scholar 

  8. 8.

    Perfumi M, Mattioli L. Adaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in mice. Phytother Res 2007;21:37–43.

    PubMed  Article  CAS  Google Scholar 

  9. 9.

    Bystritsky A, Kerwin L, Feusner JD. A pilot study of Rhodiola rosea (Rhodax) for generalized anxiety disorder (GAD). J Altern Complement Med 2008;14:175–180.

    PubMed  Article  Google Scholar 

  10. 10.

    Colson SN, Wyatt FB, Johnston DL, Autrey LD, FitzGerald YL, Earnest CP. Cordyceps sinensis- and Rhodiola rosea-based supplementation in male cyclists and its effect on muscle tissue oxygen saturation. J Strength Cond Res 2005;19:358–363.

    PubMed  Article  Google Scholar 

  11. 11.

    Darbinyan V, Aslanyan G, Amroyan E, Gabrielyan E, Malmström C, Panossian A. Clinical trial of Rhodiola rosea L. extract SHR-5 in the treatment of mild to moderate depression. Nord J Psychiatry 2007;61:343–348.

    PubMed  Article  CAS  Google Scholar 

  12. 12.

    Darbinyan V, Kteyan A, Panossian A, Gabrielian E, Wikman G, Wagner H. Rhodiola rosea in stress induced fatigue— a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. Phytomedicine 2000;7:365–371.

    PubMed  CAS  Google Scholar 

  13. 13.

    De Bock K, Eijnde BO, Ramaekers M, Hespel P. Acute Rhodiola rosea intake can improve endurance exercise performance. Int J Sport Nutr Exerc Metab 2004; 14:298–307.

    PubMed  Google Scholar 

  14. 14.

    Earnest CP, Morss GM, Wyatt F, Jordan AN, Colson S, Church TS, et al. Effects of a commercial herbal-based formula on exercise performance in cyclists. Med Sci Sports Exerc 2004;36:504–509.

    PubMed  Article  Google Scholar 

  15. 15.

    Fintelmann V, Gruenwald J. Efficacy and tolerability of a Rhodiola rosea extract in adults with physical and cognitive deficiencies. Adv Ther 2007;24:929–939.

    PubMed  Article  Google Scholar 

  16. 16.

    Shevtsov VA, Zholus BI, Shervarly VI, Vol’skij VB, Korovin YP, et al. A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work. Phytomedicine 2003;10:95–105.

    PubMed  Article  CAS  Google Scholar 

  17. 17.

    Spasov AA, Wikman GK, Mandrikov VB, Mironova IA, Neumoin VV. A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen. Phytomedicine 2000;7:85–89.

    PubMed  CAS  Google Scholar 

  18. 18.

    Wing SL, Askew EW, Luetkemeier MJ, Ryujin DT, Kamimori GH, Grissom CK. Lack of effect of Rhodiola or oxygenated water supplementation on hypoxemia and oxidative stress. Wilderness Environ Med 2003;14:9–16.

    PubMed  Google Scholar 

  19. 19.

    Mahadevan S, Park Y. Multifaceted therapeutic benefits of Ginkgo biloba L.: chemistry, efficacy, safety, and uses. J Food Sci 2008;73:R14–R19.

    PubMed  CAS  Article  Google Scholar 

  20. 20.

    Schulz V. Ginkgo extract or cholinesterase inhibitors in patients with dementia: what clinical trials and guidelines fail to consider. Phytomedicine 2003;10(S4):74–79.

    PubMed  CAS  Article  Google Scholar 

  21. 21.

    Gertsch JH, Basnyat B, Johnson EW, Onopa J, Holck PS. Randomised, double blind, placebo controlled comparison of Ginkgo biloba and acetazolamide for prevention of acute mountain sickness among Himalayan trekkers: the prevention of high altitude illness trial (PHAIT). BMJ 2004;328:797.

    PubMed  Article  CAS  Google Scholar 

  22. 22.

    Gertsch JH, Seto TB, Mor J, Onopa J. Ginkgo biloba for the prevention of severe acute mountain sickness (AMS) starting one day before rapid ascent. High Alt Med Biol 2002;3:29–37.

    PubMed  Article  Google Scholar 

  23. 23.

    Pittler MH, Ernst E. Ginkgo biloba extract for the treatment of intermittent claudication: a meta-analysis of randomized trials. Am J Med 2000;108:276–281.

    PubMed  Article  CAS  Google Scholar 

  24. 24.

    Gardner CD, Taylor-Piliae RE, Kiazand A, Nicholus J, Rigby AJ, Farquhar JW. Effect of Ginkgo biloba (EGb 761) on treadmill walking time among adults with peripheral artery disease: a randomized clinical trial. J Cardiopulm Rehabil Prev 2008;28:258–265.

    PubMed  Google Scholar 

  25. 25.

    Wang J, Zhou S, Bronks R, Graham J, Myers S. Supervised exercise training combined with Ginkgo biloba treatment for patients with peripheral arterial disease. Clin Rehabil 2007;21:579–586.

    PubMed  Article  Google Scholar 

  26. 26.

    Pharmacopoeia Commission of China. Pharmacopoeia of the People’s Republic of China, 2005 ed. Beijing: Chemical Industry Press; 2005:211–212, 322–323.

    Google Scholar 

  27. 27.

    Bar-Or O. The Wingate anaerobic test. An update on methodology, reliability and validity. Sports Med 1987;4:381–394.

    PubMed  Article  CAS  Google Scholar 

  28. 28.

    Baba R, Nagashima M, Goto M, Nagano Y, Yokota M, Tauchi N, et al. Oxygen uptake efficiency slope: a new index of cardiorespiratory functional reserve derived from the relation between oxygen uptake and minute ventilation during incremental exercise. J Am Coll Cardiol 1996;28:1567–1572.

    PubMed  Article  CAS  Google Scholar 

  29. 29.

    Reilly T, Ekblom B. The use of recovery methods post-exercise. J Sports Sci 2005;23:619–627.

    PubMed  Article  Google Scholar 

  30. 30.

    Urhausen A, Kindermann W. Diagnosis of overtraining: what tools do we have? Sports Med 2002;32:95–102.

    PubMed  Article  Google Scholar 

  31. 31.

    Peters H, Kieser M, Hölscher U. Demonstration of the efficacy of Ginkgo biloba special extract EGb 761 on intermittent claudication—a placebo-controlled, double-blind multicenter trial. Vasa 1998;27:106–110.

    PubMed  CAS  Google Scholar 

  32. 32.

    Moraga FA, Flores A, Serra J, Esnaola C, Barriento C. Ginkgo biloba decreases acute mountain sickness in people ascending to high altitude at Ollagüe (3696 m) in northern Chile. Wilderness Environ Med 2007;18(4):251–7.

    PubMed  Article  Google Scholar 

  33. 33.

    Battistelli M, De Sanctis R, De Bellis R, Cucchiarini L, Dachà M, Gobbi P. Rhodiola rosea as antioxidant in red blood cells: ultrastructural and hemolytic behaviour. Eur J Histochem 2005;49:243–254.

    PubMed  CAS  Google Scholar 

  34. 34.

    De Sanctis R, De Bellis R, Scesa C, Mancini U, Cucchiarini L, Dachà M. In vitro protective effect of Rhodiola rosea extract against hypochlorous acid-induced oxidative damage in human erythrocytes. Biofactors 2004;20:147–159.

    PubMed  Article  Google Scholar 

  35. 35.

    Köse K, Doğan P, Aşçioğlu M, Aşçioğlu O. In vitro antioxidant effect of Ginkgo biloba extract (EGb 761) on lipoperoxidation induced by hydrogen peroxide in erythrocytes of Behçet’s patients. Jpn J Pharmacol 1997;75:253–258.

    PubMed  Article  Google Scholar 

  36. 36.

    Köse K, Doğan P. Lipoperoxidation induced by hydrogen peroxide in human erythrocyte membranes. 1. Protective effect of Ginkgo biloba extract (EGb 761). J Int Med Res 1995;23:1–8.

    PubMed  Google Scholar 

  37. 37.

    Köse K, Doğan P. Lipoperoxidation induced by hydrogen peroxide in human erythrocyte membranes. 2. Comparison of the antioxidant effect of Ginkgo biloba extract (EGb 761) with those of water-soluble and lipid-soluble antioxidants. J Int Med Res 1995;23:9–18.

    PubMed  Google Scholar 

  38. 38.

    Sarikçioğlu SB, Oner G, Tercan E. Antioxidant effect of EGb 761 on hydrogen peroxide-induced lipoperoxidation of G-6-PD deficient erythrocytes. Phytother Res 2004;18:837–840.

    PubMed  Article  CAS  Google Scholar 

  39. 39.

    Abidov M, Crendal F, Grachev S, Seifulla R, Ziegenfuss T. Effect of extracts from Rhodiola rosea and Rhodiola crenulata (Crassulaceae) roots on ATP content in mitochondria of skeletal muscles. Bull Exp Biol Med 2003;136:585–587.

    PubMed  Article  CAS  Google Scholar 

  40. 40.

    Carlson JJ, Farquhar JW, DiNucci E, Ausserer L, Zehnder J, Miller D, et al. Safety and efficacy of a ginkgo biloba-containing dietary supplement on cognitive function, quality of life, and platelet function in healthy, cognitively intact older adults. J Am Diet Assoc 2007;107:422–432.

    PubMed  Article  Google Scholar 

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Correspondence to Yao Tong 童 瑶.

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Supported by Integrated Chinese Medicine Holdings Ltd., Hong Kong, China

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Zhang, Z., Tong, Y., Zou, J. et al. Dietary supplement with a combination of Rhodiola crenulata and Ginkgo biloba enhances the endurance performance in healthy volunteers. Chin. J. Integr. Med. 15, 177–183 (2009). https://doi.org/10.1007/s11655-009-0177-x

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Key Words

  • herbal supplement
  • endurance
  • maximal oxygen uptake
  • cortisol
  • testosterone
  • clinical trial