Abstract
Objective
To study the effect of Jinguo Weikang Capsule (金果胃康胶囊, JWC) on the gene expression of H-ras, epidermal growth factor receptor (EGFR), P53 and C-myc of the gastric mucosa in rats with gastric precancerous lesions, and to investigate the action mechanism of JWC on gastric precancerous lesions.
Methods
A rat model with paratypical proliferation of the gastric epithelium mucosa was established by using 60Co irradiation. Rats were divided into the normal group, model group, high-, medium-, low-dose JWC treatment groups, and the vitacoenzyme control group, and were treated for 30 days. The expression of H-ras, EGFR, P53 and C-myc genes of the gastric mucosa was detected by using immunohistochemical methods.
Results
The expression and over-expression rates of H-ras, EGFR, P53 and C-myc gene in the high-and medium-dose JWC treatment groups were significantly lower (P<0.05) as compared with those of the model group.
Conclusion
JWC can inhibit the expression of the H-ras, EGFR, P53 and C-myc genes expression of the gastric mucosa in rats, which may be one of mechanisms involved in suppressing or reversing gastric carcinogenesis.
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Supported by the Bureau of Science and Techology of Shaanxi Province [No. 2002Kll-G7(6)]
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Shen, Sw., Yuwen, Y., Zhang, Zl. et al. Effect of Jinguo Weikang Capsule (金果胃康胶囊) on proto-oncogene expression of gastric mucosa in rats with gastric precancerous lesions. Chin. J. Integr. Med. 14, 212–216 (2008). https://doi.org/10.1007/s11655-008-0212-3
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DOI: https://doi.org/10.1007/s11655-008-0212-3