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Effect of volatile oil of amomum on expressions of platelet activating factor and mastocarcinoma-related peptide in the gastric membrane of chronic gastritis patients with helicobacter-pylori infection

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Abstract

Objective

To observe the effect of volatile oil of amomum (VOA) on the expressions of mastocarcinoma-related peptide (PS2) and platelet activating factor (PAF) in helicobacter pyloriassociated gastritis (HPG) and to analyze its potential mechanism.

Methods

Eighty patients with HPG were randomly assigned to two groups, 42 patients in the treated group treated with 0.5 mL VOA, thrice per day; and the 38 patients in the control group receiving Western tertiary medicinal treatment. Gastroscopic picture and helicobacter pylori (HP) infection (by quick urease and Warthin-Starry stain) of the gastro-membrane, expressions of PS2 and PAF (by immunohistochemical assay and Western blotting) as well as the contents of aminohexose and phospholipid (by Neuhaus method) in the gastric membrane of all patients were detected before treatment and 4 weeks after treatment. The clinical effi cacy in the two groups was compared.

Results

The total effective rate in the treated group was 88.1%, which was significantly higher than that in the control group (78.9%, P<0.05). After treatment, in the treated group, gastric membranous contents of aminohexose and phospholipid was increased, expression of PS2 elevated but that of PAF lowered, all showing significant difference as compared with those in the control group (P<0.01). In the control group, the expressions of PS2 and PAF changed insignificantly. The radical eliminating rate of HP in the treated group and the control group was insignificantly different between them (76.1% vs. 65.8%, P>0.05).

Conclusion

The mechanism of VOA for anti-gastritis might be related with its action in increasing the expression of PS2 and decreasing the expression of PAF, and thus regulating the hydrophobicity of the gastric membrane.

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Authors and Affiliations

  1. Department of Integrative Medicine, the First Affiliated Hospital of Nanchang University, Nangchang, 330066, China

    Guo-dong Huang  (黄国栋)

  2. Hengyang Hospital, Hunan University of Chinese Medicine, Hunan, China

    Yuan-hua Huang  (黄媛华), Mei-zhen Xiao  (肖美珍) & Dao-fu Huang  (黄道富)

  3. Changsha Medical College, Changsha, China

    Juan Liu  (刘娟)

  4. Xiangya Hospital of Central South University, Changsha, 410008, China

    Jia-bang Li  (李家邦)

Authors
  1. Guo-dong Huang  (黄国栋)
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  2. Yuan-hua Huang  (黄媛华)
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  3. Mei-zhen Xiao  (肖美珍)
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  4. Dao-fu Huang  (黄道富)
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  5. Juan Liu  (刘娟)
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  6. Jia-bang Li  (李家邦)
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Corresponding author

Correspondence to Jia-bang Li  (李家邦).

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Huang, Gd., Huang, Yh., Xiao, Mz. et al. Effect of volatile oil of amomum on expressions of platelet activating factor and mastocarcinoma-related peptide in the gastric membrane of chronic gastritis patients with helicobacter-pylori infection. Chin. J. Integr. Med. 14, 23–27 (2008). https://doi.org/10.1007/s11655-008-0023-6

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  • DOI: https://doi.org/10.1007/s11655-008-0023-6

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