Abstract
Objective
To observe the clinical efficacy and adverse reactions of Paroxetine combined with electro-acupuncture (EA) in treating depression.
Methods
Forty-two patients with depression were randomly assigned to the observation group (22 patients) treated with EA combined with Paroxetine, and the control group (20 patients) treated with Paroxetine alone, and the therapeutic course for both groups was 6 weeks. The therapeutic efficacy and adverse reactions were evaluated with scores by Hamilton depression scale (HAMD) and treatment emergent symptoms scale (TESS), respectively.
Results
HAMD scores determined at the end of the 1st, 2nd, 4th, and 6th week of the treatment course were significantly lower in the observation group than those in the control group (P<0.05). The significant improvement rate evaluated at the end of the 6-week treatment was remarkably higher in the observation group than that in the control group (72.7% vs 40.0%). No significant difference of TESS scores was found between the two groups.
Conclusion
EA combined with Paroxetine has better clinical efficacy than that of Paroxetine alone, with milder adverse reaction and quicker initiation of effect.
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References
Keller MB, Lavori PW, Mueller TI, et al. Time to recovery, chronicity, and levels of psychopathology in major depression: a 5-year prospective follow-up of 431 subjects. Arch Gen Psychiatry 1992;49:809–816.
Rudolph RL. Achieving remission from depression with venlafaxine and venlafaxine extended release: a literature review of comparative studies with selective serotonin reuptake inhibitors. Acta Psychiatr Scand Suppl 2002;106:24–30.
Chinese Society of Psychiatry, Chinese Medical Association. Chinese standard for sorting and diagnosis of mental disorder. 3rd ed. Jinan: Shandong Science and Technology Publishing House, 2001:87–89
Luo HC. Clinical observation and experimental study on treatment of depression by electroacupuncture. J Beijing Med Univ 1987;19(1):45–47.
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Zhang, Gj., Shi, Zy., Liu, S. et al. Clinical observation on treatment of depression by electro-acupuncture combined with Paroxetine. Chin. J. Integr. Med. 13, 228–230 (2007). https://doi.org/10.1007/s11655-007-0228-0
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DOI: https://doi.org/10.1007/s11655-007-0228-0