Abstract
Objective
To investigate the effects of Corocalm (Shuguan Capsule, 疏冠胶囊) on acute myocardial ischemia in anesthetized dogs and its possible therapeutic mechanism.
Methods
The acute ischemia model was established by ligating the left anterior descending (LAD) artery. Twenty-five dogs were randomly divided into 5 groups (5 dogs in each group): the control group (treated with normal saline 3 mL/kg), the refi ned Guanxin Capsule group (精制冠心胶囊, GXC 200 mg/kg), high and low dose Corocalm groups (48.5 mg/kg for low dose group and 194.0 mg/kg for high dose group) and the Diltiazem group (5 mg/kg). The animals were treated via a single duodenal administration after the model was established. The experiments used epicardial electrocardiogram (EECG) to measure the scope and degree of myocardial ischemia. Simultaneously, the coronary blood fl ow (CBF) and serum activity levels of creatine phosphokinase (CK) and lactate dehydrogenase (LDH) were measured by electromagnetic fl ow meter and automatic biochemical analyzer respectively. The plasma endothelin (ET) content was quantified by radioimmunoassay.
Results
Corocalm (48.5 mg/kg and 194.0 mg/kg) signifi cantly decreased the degree and scope of myocardial ischemia, reduced the infarct area, markedly increased the CBF, and inhibited the increase of CK and LDH activities and ET levels induced by myocardial ischemia/infarction.
Conclusion
Corocalm could improve the state of acute myocardial ischemia and infarction in dogs. The mechanism of action might be correlated to increasing CBF, inhibiting CK and LDH activities and preventing ET release.
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References
Liu JX, Shang XH, Wang G, et al. Effects of Tongxinluo Capsule on experimental myocardial ischemia, arrhythmia and hyperlipidemia. Chin J Intergr Tradit West Med 1997; 17(7):425–428.
Department of Pharmacology, Xiyuan Hospital, China Academy of Traditional Chinese Medicine. The improvement of epicardial electrogram methods. New Med Pharm J 1978;24(11):52–53.
Liu JX, Shang XH, Fu JH, et al. Effects of recombinant staphylokinase on coronary thrombosis in Chinese experimental miniature swine. Acta Pharmacol Sin 2002;23(6):509–515.
Li XZ, Liu JX, Shang XH, et al. Comparative research on the protective effects of ginsenosides extracted from different parts of ginseng on acute myocardial ischemia in dogs. Tradit Chin Drug Res Clin Pharmacol 2006;17(2):83–86.
Gerber BL, Wijns W, Vanoverschelde JL, et al. Myocardial perfusion and oxygen consumption in reperfused noninfarcted dysfunctional myocardium after unstable angina: Direct evidence for myocardial stunning in humans. J Am Coll Cardiol 1999; 34:1939–1946.
Panteghini M, Apple FS, Christenson RH, et al. Use of biochemical markers in acute coronary syndromes. IFCC Scientific Division, Committee on Standardization of Markers of Cardiac Damage. International Federation of Clinical Chemistry. Clin Chem Lab Med 1999;37: 687–693.
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Supported by the National Key Technology Program Foundation during the 9th Five-Year Plan Period (No. 96-903-01-02)
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Liu, Jx., Li, Xz., Cong, Wh. et al. Effects of Corocalm (Shuguan Capsule, 疏冠胶囊) on acute myocardial ischemia in anesthetized dogs. Chin. J. Integr. Med. 13, 206–210 (2007). https://doi.org/10.1007/s11655-007-0206-6
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DOI: https://doi.org/10.1007/s11655-007-0206-6