Abstract
Erxian Tang (二仙汤, EXT) is a Chinese herbal formula developed for the treatment of menopausal syndrome in women. In the past 50 years, EXT has shown positive efficacy in the treatment of many chronic diseases in TCM, involving syndrome types of Shen yin-yang deficiency, yin-deficiency caused yang-flourishing, and disharmony of Chong-Ren meridian. Experimental studies have revealed that EXT has multiple pharmacological actions on such multiple targets as hypothalamus-pituitary-target gland axis, immune function and free radical metabolism, etc.
Similar content being viewed by others
References
Zhang BN. The theory and treatment of hypertension in traditional Chinese medicine. Shanghai: Shanghai Press of Scientific Technology, 1959:2–36.
Zhang BN. To subjugate hypertersion by enhancing traditional Chinese medicine. Chin J Int Med 1958;6(12):1145.
Fang ZQ, Xu PC, Zhang BN. The effect of Er-xian decoction (Two Fairy Decoction) with its separate prescriptions on the content of plasma sex hormones and gonadotrophic hormone of aged rats. China J Tradit Chin Med Pharmacy 1992;7(5):24–26.
Dan B, Randall B. Chinese herbal medicine-formulas and strategies. Seattle: Eastland Press, 1990:282–283.
Ran XD. Chinese Herbal medicine (Zhong Hua Yao Hai). Harbin: Harbin Press, 1993: 1586, 1716, 1566, 446, 1610.
Chen J, Chen T. Chinese medical herbology and pharmacology, City of Industry. CA: Art of Medicine Press, 2001: 896, 894, 891, 111, 45, 918.
Yang GS. Er Xian Tang is credited with warming yang and nurturing yin. Shanghai J Tradit Chin Med 1986;7(2): 26.
Li JJ. Progress in the clinical application and researches of Ex Xian Tang. Acta Univ Tradit Med Sinensis Pharmacol Shanghai 1993;7(1):61–65.
Chen SG, Fang F. The Zhi An Shen’s experience of Ex Xian Tang treatment for menopausal Syndrome. Jiangxi J Tradit Chin Med 1998;29(1):5.
Zhang LF. The samples of effective clinical cases of Er Xian Tang application by professor Wenzhen Huang. Fujian J Tradit Chin Med 2004;35(1):19–22.
Zhang BN. Clinical effects of traditional Chinese medicine on 328 patients with hypertension over the course of four years. Chin J Int Med 1965;13(6):501–503.
Wang CH, Li F, Xing L, et al. The treatment of Er Xian Tang for 50 cases of menopausal syndrome. Shaanxi J Tradit Chin Med 1997;18(6):253.
Li Y. Er Xian Tang combined with Gan Mei Da Zao Tang was treated in 118 female case of menopausal syndrome. Shanghai J Tradit Chin Med 2004;38(2):43–44.
Lu SB, Chen CL. The treatment of ovarian ablation menopausal syndrome with Er Xian Tang. Shandong J Tradit Chin Med 1998;17(12):547.
Liu L, Qing ZF. Er Xian Tang as a primary treatment of 35 cases of menopause-like symptoms induced by breast cancer treatment. Zhejiang J Tradit Chin Med 2004;39(2): 75.
Yang GS. The treatment of male menopause syndrome with Er Xian Tang. Liaoning J Tradit Chin Med 1986;9(4):31.
Xu X, Zhang XA. Er Xian Tang as the main treatment of 35 cases of male menopausal syndrome. Fujian J Tradit Chin Med 1997;28(6):51.
Zhang JX. Experience of menopausal syndrome treatment with Er Xian Tang. Qinghai Med J 2000;30(6):57–58.
Chen WY. Er Xian Tang modification treatment of 62 cases of ovulation bleeding. Anhui J Tradit Chin Clin Med 2001;13(4):327.
Yin MS. 26 infertility cases of planning treatment according to diagnosis of traditional Chinese medicine. Jilin J Tradit Chin Med 1994;14(3):31.
Qiu Y, Yang DT, Wang SM. Treatment of immunologic infertility by Ex Xian Soup with prednisone and intrauterine insemination with husband’s sperm. Chin J Family Planning 1998; 6(9):406–407.
Wang CH, Zhang ZH, Ma J. Clinical study on treating osteoporosis by tonifing Shen (肾) in traditional Chinese medicine. Acta Chin Med Pharmacol 1998;7(5):20–21.
Wang YQ, Zhao CJ. The ischemic necrosis of adult femoral head was treated with Er Xian Tang. China J Orthopaedics Traumatol 1994;7(5):36.
Zhang CQ. Er Xian Tang modification treatment of cervical spondylopathy. J Yunnan Coll Tradit Chin Med 1996;19(2):31–32.
Chen LE. Case studies on Er Xian Tang modification treatment on degenerative joint disease of the lumbosacral. Clin J Tradit Chin Med 1996;8(2):79.
Han YL. Er Xian Tang modification treatment of 94 cases of scapulohumeral periarthritis. J Tradit Chin Med 2001;36(1):20.
Liang CY. Treatment of 67 cases of primary thrombocytopenic purpura by Er Xian Tang. J Hubei Coll Tradit Chin Med 1996;18(3):17–18.
Su ZZ. Leucopenia cases treated with modified Er Xian Tang. Forum Tradit Chin Med 1997;12(6):30.
Yang XC. 70 chronic prostatitis cases treated with Er Xian Tang. Forum Tradit Chin Med 1998;13(6):34.
Guo JW. The modified application of Er Xian Tang in 64 patients with depressive disorders. Shaanxi J Tradit Chin Med 1988;9(2):59.
Huang YB, Zheng ZL. The effect of Er Xian Tang treatment on 210 patients of recurrent oral apthous ulcers. J Sichuan Tradit Chin Med 1997;15(5):52.
He XR. The treatment of spermatopathy with Er Xian Tang. Shanghai J Tradit Chin Med 1990; 24(12):30.
Zhang SH, Wang HR. Treatment of neurodermatitis by Er Xian Tang modification in 36 cases. Inner Mongollia J Tradit Chin Med 2002;21(1):45.
Wang YQ. One case of Addison’s disease cured with Er Xian Tang. J Sichuan Tradit Chin Med 1996;14(7):35.
He Z. The cases of systemic lupus erythematosus cured with modified Er Xian Tang. J Sichuan Tradit Chin Med 1989;5(3):27.
Bian WH, Xu ZY. The treatment of thyroid diseases with the therapy of reinforcing the body resistance. Shanxi J Tradit Chin Med 1997;13(3):54–55.
Cui GB. Diabetic bladder dysfunction treatment of Er Xian Tang modification. J Pract Tradit Chin Int Med 2000;14(3):22.
Chen WZ. The study of anti-hypertension medicine. Pharmacy Acta 1960; 6(1):35.
Zhao GS. Clinical and pharmaceutical study of Er Xian Mixture in decreasing hypertension. Pharmacy Acta 1962;9(5):287.
Fang ZQ, Sl FZ, Zhang BN, et al. The regulation of Er Xian Decoction and its separated prescriptions on GnRH gene expression in old rat hypothalamus. Chin J Basic Med Tradit Chin Med 1998;4(1):23–25.
Yang Y, Chen MD, Li FY, et al. Effects of Two Fairy Decoction and its decomposed recipe on gonadotropin releasing hormone secreted by GT 1–7 cell Line. Chin J Integr Tradit West Med Intens Crit Care 2001;8(3):143–145.
Liao BS, Hu Y, Ju G, et al. The effects of Er Xian Tang on the EOP content and levels of POMC mRNA Gene expression in the hypothalamus in 18-month-old female rats. J Shandong Coll radit Chin Med 1996;20(6):399–401.
Zhou JH, Huang JH, editors. Volume III of the development of pharmacology and clinical research in Chinese herbal medicine. Beijing: Military Medical Science Press, 1995;230–241.
Fang ZQ, Zhang BN, Xu FX. The effect of Er-xian decoction with its separate prescriptions on the content of sex hormones receptors in the cytoplasm and nucleus of prostate and uterus of aged rats. Nuclear Techni 1992;15(11):696–698.
Liu Q, Shi JR, Yang Y, et al. Effects on secretory function of rat gonad by Erxian Decoction and its disassembled prescriptions. China J Chin Materia Medica 2005;30(13):1023–1026.
Liu Q, Shi JR, Yang Y, et al. Study on composing mechanism of Erxian decoction. Chin Pharm J 2005;40(21):1622–1625.
Zheng XW, Bao SZ, Li RQ, et al. Effects of Er-Xian Decoction on gene expression of ACTH in pituitary tissue in Shen (肾)-yang deficiency rats. Acta Chin Med Pharmacol 2003;18(12):716–718.
Zheng XW, Li RQ, Song H. The effects of Erxian Decoction on ACTH in Shen (肾)-yang deficiency Rats. Chin J Inform Tradit Chin Med 2003;10(8):33–34.
Xu WR, Ye QM, Fang ZQ, et al. Effect of Erxian Decoction and its separated recipes on histology and histochemistry of reticular zone of adrenal cortex in castrated rats. Acta Univ Tradit Med Sinensis Pharmacol Shanghai 1995;9(1)55–57.
Shen XH, Zhang BN, Fang ZQ, et al. Study of Er Xian Decoction on free radical metabolism in aging rats. Shanghai J Tradit Chin Med 1996;20(3):40–42.
Chen T, Zhang BN, Gu WC. Effect of Er-xian decoction and its separated prescriptions on thymus gland and cellular immune function of aged rats. Liaoning J Tradit Chin Med 1993;20(12):40–42.
Shen XH, Fang ZQ, Wu DX, et al. Effects of Er Xian Decoction and its separated prescriptions on enzyme activities and their gene expression of antioxidant enzymes in aging rats. Chin J Integr Tradit West Med 1995;15(11):672–674.
Chen T. Influences of Er Xian Tang and its disintegrated Recipes on SOD, LPO, and lipofusein of aged rats. Chin J Integr Tradit West Med 1993 (Special Issue)13:75–77.
Wang HH, An W, Liu GQ, et al. Effect of modified Erxian tang on water content and SOD activity of rats with acute incomplete cerebral ischemia. J Taishan Med Coll 2001;22(2):106.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Li, Jj., Li, J.T. & Fu, Jp. Erxian Tang (二仙汤)—Introduction of a Chinese herbal formula, clinical practice, and experimental studies. Chin. J Integ. Med. 13, 67–73 (2007). https://doi.org/10.1007/s11655-007-0067-z
Received:
Issue Date:
DOI: https://doi.org/10.1007/s11655-007-0067-z