Chinese Journal of Integrative Medicine

, Volume 12, Issue 4, pp 268–272 | Cite as

Effect of Compound Glycyrrhizin Injection on liver function and cellular immunity of children with infectious mononucleosis complicated liver impairment

  • Cao Zong-xin  (曹宗新)Email author
  • Zhao Zhong-fang  (赵忠芳)
  • Zhao Xiu-fen  (赵秀芬)



To investigate the effects of Compound Glycyrrhizin Injection (CGI) on liver function and cellular immunity of children with infectious mononucleosis complicated liver impairment (IM-LI) and to explore its clinical therapeutic effect.


Forty-two patients with IM-LI were randomly assigned, according to the randomizing number table, to two groups, 20 in the control group and 22 in the treated group. All the patients were treated with conventional treatment, but to those in the treated group, CGI was given additionally once a day, at the dosage of 10 ml for children aged below 2 years, 20 ml for 2–4 years old, 30 ml for 5–7 years old and 40 ml for 8–12 years old, in 100–200 ml of 5% glucose solution by intravenous dripping. The treatment lasted for 2 weeks. T lymphocyte subsets and serum levels of alanine transaminase (ALT), aspartate aminotransferase (AST) and total bilirubin (TBil) were detected before and after treatment. Besides, a normal control group consisting of 20 healthy children was also set up.


Baseline of the percentage of CD3 +, CD8 + lymphocyte and serum levels of ALT, AST, TBiL in the children with IM-LI were markedly higher, while the percentage of CD4 + lymphocyte and the CD4 +/CD8 + ratio was markedly lower in IM-LI children as compared with the corresponding indices in the healthy children (P<0.01). These indices were improved after treatment in both groups of patients, but the improvement in the treated group was better than that in the control group (P<0.01).


Cellular immunity dysfunction often occurs in patients with IM-LI, and CGI treatment can not only obviously promote the recovery of liver function, but also regulate the immune function in organism.

Key Words

infectious mononucleosis liver impairment T lymphocyte subsets Compound Glycyrrhizin Injection treatment 


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Copyright information

© Chinese Association of Traditional and Western Medicine, China Academy of Chinese Medical Sciences 2006

Authors and Affiliations

  • Cao Zong-xin  (曹宗新)
    • 1
    Email author
  • Zhao Zhong-fang  (赵忠芳)
    • 2
  • Zhao Xiu-fen  (赵秀芬)
    • 1
  1. 1.Department of PediatricsCentral People’s Hospital of Tengzhou CityShandongChina
  2. 2.Wangkai Hospital of Infectious DiseaseZaozhuang CityChina

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