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One dose to treat them all? – Therapeutisches Drug Monitoring zur Dosisoptimierung in der oralen Antitumortherapie

One dose to treat them all? Therapeutic drug monitoring for dose optimization in oral anticancer treatment

  • Onkologische Pharmazie
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best practice onkologie Aims and scope

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Literatur

  1. Groenland SL, Mathijssen RHJ, Beijnen JH et al (2019) Individualized dosing of oral targeted therapies in oncology is crucial in the era of precision medicine. Eur J Clin Pharmacol 75:1309–1318

    Article  PubMed  Google Scholar 

  2. Mathijssen RHJ, Sparreboom A, Verweij J (2014) Determining the optimal dose in the development of anticancer agents. Nat Rev Clin Oncol 11:272–281

    Article  CAS  PubMed  Google Scholar 

  3. McLaughlin AM, Schmulenson E, Teplytska O et al (2021) Developing a nationwide infrastructure for therapeutic drug monitoring of targeted oral anticancer drugs: The ON-TARGET study protocol. Cancers 13:1–15

    Google Scholar 

  4. Mueller-Schoell A, Groenland SL, Scherf-Clavel O et al (2021) Therapeutic drug monitoring of oral targeted antineoplastic drugs. Eur J Clin Pharmacol 77:441–464

    Article  PubMed  Google Scholar 

  5. Touw DJ, Neef C, Thomson AH, Vinks AA et al (2005) Cost-effectiveness of therapeutic drug monitoring: a systematic review. Ther Drug Monit 27:10–17

    Article  CAS  PubMed  Google Scholar 

  6. Yu H, Steeghs N, Nijenhuis CM et al (2014) Practical guidelines for therapeutic drug monitoring of anticancer tyrosine kinase inhibitors: focus on the pharmacokinetic targets. Clin Pharmacokinet 53:305–325

    Article  CAS  PubMed  Google Scholar 

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Correspondence to U. Jaehde.

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Interessenkonflikt

C. Kloft erhält Forschungsunterstützungen von einem Industriekonsortium (Fa. AbbVie Deutschland GmbH & Co. KG, Fa. AstraZeneca, Fa. Boehringer Ingelheim Pharma GmbH & Co. KG, Fa. F. Hoffmann-La Roche Ltd, Fa. Merck KGaA, Fa. Novo Nordisk A/S und Fa. Sanofi) für das Graduiertenprogramm PharMetrX. O. Teplytska, F. Klima, N. Haas und U. Jaehde geben an, dass kein Interessenkonflikt besteht.

Für diesen Beitrag wurden von den Autor/-innen keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.

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O. Teplytska und F. Klima teilen sich die Erstautorenschaft; C. Kloft und U. Jaehde teilen sich die Seniorautorenschaft.

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Teplytska, O., Klima, F., Haas, N. et al. One dose to treat them all? – Therapeutisches Drug Monitoring zur Dosisoptimierung in der oralen Antitumortherapie. best practice onkologie 18, 258–261 (2023). https://doi.org/10.1007/s11654-023-00486-9

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  • DOI: https://doi.org/10.1007/s11654-023-00486-9

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