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Thromboseprophylaxe und -therapie bei Tumorpatienten

Richtiges Vorgehen in Krankenhaus und Praxis

  • CME • TOPIC • thromboseprophylaxe und -therapie
  • Published:
best practice onkologie Aims and scope

Zusammenfassung

Häufig werden Tumorerkrankungen primär oder in ihrem Verlauf durch venöse Thrombosen und/oder Lungenembolien kompliziert. Dies bedeutet für die betroffenen Patienten ein erhöhtes Mortalitätsrisiko: Venöse Thromboembolien wurden in Untersuchungen als zweithäufigste zum Tode der Patienten führende Komplikation identifiziert. Der Beitrag gibt einen Überblick zur Prophylaxe und Behandlung von venösen Thromboembolien bei Tumorpatienten.

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Literatur

  1. Agnelli G, Gussoni G, Bianchini C et al (2008) A randomized doubleblind placebocontrolled study on nadroparin for prophylaxis of thromboembolic events in cancer patients receiving chemotherapy: The PROTECHT Study. Blood 112: 6 (abstr)

    Google Scholar 

  2. Bottaro FJ, Elizondo MC, Doti C et al (2008) Efficacy of extended thromboprophylaxis in major abdominal surgery: What does the evidence show? A metaanalysis. Thromb Haemost 99: 1104–1111

    CAS  PubMed  Google Scholar 

  3. Chaukiyal P, Nautiyal A, Radhakrishnan S et al (2008) Thromboprophylaxis in cancer patients with central venous catheters: A systematic review and metaanalysis. Thromb Haemost 99: 38–43

    CAS  PubMed  Google Scholar 

  4. Falanga A, Marchetti M (2009) Venous Thromboembolism in the Hematologic Malignancies. J Clin Oncol 27: 4848–4857

    Article  CAS  PubMed  Google Scholar 

  5. Geerts WH, Bergqvist D, Pineo GF et al (2008) Prevention of venous thromboembolism: American College of Chest Physicians EvidenceBased Clinical Practice Guidelines (ed 8). Chest 133: 381S–453S

    Article  CAS  PubMed  Google Scholar 

  6. Herishanu Y, Misgav M, Kirgner I et al (2004) Enoxaparin can be used safely in patients with severe thrombocytopenia due to intensive chemotherapy regimens. Leuk Lymphoma 45: 1407–1411

    Article  CAS  PubMed  Google Scholar 

  7. Kearon C, Kahn SR, Agnelli G et al (2008) Antithrombotic therapy for venous thromboembolic disease: American College of Chest Physicians evidencebased clinical practice guidelines (ed 8). Chest 133: 454S–545S

    Article  CAS  PubMed  Google Scholar 

  8. Klerk CP, Smorenburg SM, Otten HM et al (2005) The effect of low molecular weight heparin on survival in patients with advanced malignancy. J Clin Oncol 23: 2130–2135

    Article  CAS  PubMed  Google Scholar 

  9. Khorana AA, Kuderer NM, Culakova E et al (2008) Development and validation of a predictive model for chemotherapyassociated thrombosis. Blood 111: 4902–4907

    Article  CAS  PubMed  Google Scholar 

  10. Kuderer NM, Khorana AA, Lyman GH et al (2007) A metaanalysis and systematic review of the efficacy and safety of anticoagulants as cancer treatment: Impact on survival and bleeding complications. Cancer 110: 1149–1161

    Article  CAS  PubMed  Google Scholar 

  11. Lee AY, Levine MN, Baker RI et al (2003) Lowmolecularweight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer. N Engl J Med 349: 146–153

    Article  CAS  PubMed  Google Scholar 

  12. Prandoni P, Falanga A, Piccioli A (2005) Cancer and venous thromboembolism. Lancet Oncol 6: 401–410

    Article  PubMed  Google Scholar 

  13. Riess H, Pelzer U, Deutschinoff G et al (2009) A prospective randomized trial of chemotherapy with and without the low molecular heparin enoxaparin in patients with advanced pancreatic cancer: Results of the CONKO 004 trial. J Clin Oncol 27: 798s (abstr.)

    Google Scholar 

  14. Sorensen HT, Hohnsen SP (2008) Venous thromboembolism and subsequent shortterm risk of an occult cancer. J Thromb Haemost 6: 249–250

    CAS  PubMed  Google Scholar 

  15. Zangari M, Fink LM, Elice F et al (2009) Thrombotic events in patients with cancer receiving antiangiogenesis agents. J Clin Oncol 27: 4865–4873

    Article  CAS  PubMed  Google Scholar 

  16. Cortes C, Saura C, Atzori F (2009) risk of venous thromboembolism with Bevacizumab in cancer patients. JAMA 301:1434–1435

    Article  CAS  PubMed  Google Scholar 

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Riess, H. Thromboseprophylaxe und -therapie bei Tumorpatienten. best practice onkologie 5, 44–52 (2010). https://doi.org/10.1007/s11654-009-0207-3

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  • DOI: https://doi.org/10.1007/s11654-009-0207-3

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