Skip to main content
Log in

Kopf-Hals-Karzinome

Konzepte zur funktions- und organerhaltenden Therapie

  • TOPIC 1 · kopf-hals-karzinome
  • Published:
best practice onkologie Aims and scope

Bei der Diagnose von Kopf-Hals-Karzinomen wird nach simultanen Zweittumoren gesucht, der Halslymphknotenstatus erfasst und zumeist eine Computertomographie der Kopf-Hals-Region durchgeführt. Die Behandlungsstrategie ist heute meist eine multimodale Therapie. Sofern der Primärtumor organ- bzw. funktionserhaltend operiert werden kann, stellt die Operation die Behandlungsoption der ersten Wahl dar. Eine R0-Resektion ist immer erstrebenswert. Je nach Stadium der Erkrankung schließt sich eine adjuvante Radiotherapie bzw. bei Risikokonstellationen eine simultane Radiochemotherapie an. Bei nicht organ- bzw. funktionserhaltend operablen Tumoren ist die definitive simultane Radiochemotherapie die Behandlungsmethode der Wahl

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Literatur

  1. Adelstein DJ, Li Y, Adams GL et al. (2003) An intergroup phase III comparison of standard radiation therapy and two schedules of concurrent chemoradiotherapy in patients with unresectable squamous cell head and neck cancer. J Clin Oncol 21:92–98

    Article  PubMed  Google Scholar 

  2. Bernier J, Domenge C, Ozsahin M et al. (2004) European Organization for Research and Treatment of Cancer Trial 22931. Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer. N Engl J Med 350:1945–1952

    Article  PubMed  CAS  Google Scholar 

  3. Bonner JA, Harari PM, Giralt J et al. (2006) Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med 354:567–578

    Article  PubMed  CAS  Google Scholar 

  4. Böttcher HD, Wendt TG, Henke M (Hrsg) (2001) Klinik des Rezidivtumors im Kopf-Hals-Bereich. Grundlagen, Diagnostik, Therapie. Zuckschwerdt, München

  5. Bourhis J, Overgaard J, Audry H et al. (2006) Hyperfractionated or accelerated radiotherapy in head and neck cancer: a meta-analysis. Lancet 368:843–854

    Article  PubMed  Google Scholar 

  6. Budach W, Hehr T, Budach V et al. (2006) A metaanalysis of hyperfractionated and accelerated radiotherapy and combined chemotherapy and radiotherapy regimens in unresected locally advanced squamous cell carcinoma of the head and neck. BMC Cancer 6:28

    Article  PubMed  CAS  Google Scholar 

  7. Cooper JS, Pajak TF, Forastiere AA et al. (2004) Radiation Therapy Oncology Group 9501/Intergroup. Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck. N Engl J Med 350:1937–1944

    Article  PubMed  Google Scholar 

  8. Denis F, Garaud P, Bardet E et al. (2004) Final results of the 94–01 French Head and Neck Oncology and Radiotherapy Group randomized trial comparing radiotherapy alone with concomitant radiochemotherapy in advanced-stage oropharynx carcinoma. J Clin Oncol 22:69–76

    Article  PubMed  Google Scholar 

  9. deVita VT, Hellman S, Rosenberg SA (eds) (2005) Cancer – Principles & Practice of Oncology. 7th edn. Lippincott-Raven, New York

  10. Fietkau R, Lautenschläger C, Sauer R et al. (2006) Postoperative concurrent radiochemotherapy versus radiotherapy in high-risk SCCA of the head and neck: Results of the German phase III trial ARO 96–3. J Clin Oncol 24:5507

    Google Scholar 

  11. Harrison LB, Sessions RB, Hong WK (eds) (2004) Head and Neck Cancer. A Multidisciplinary Approach. 2nd edn. Lippincott Williams & Wilkins, Philadelphia

  12. Myers EN, Suen JY, Myers JN, Hanna EYN (2003) Cancer of the Head and Neck. 4th edn. Saunders, Philadelphia

  13. Pignon JP, Bourhis J, Domenge C et al. (2000) Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data. MACHNC Collaborative Group. Meta-analysis of chemotherapy on head and neck cancer. Lancet 355:949–955

    PubMed  CAS  Google Scholar 

  14. Rhys Evans PH, Montgomery PQ, Gullane PJ (2003) Principles and Practice of Head and Neck Oncology. Martin Dunitz, London

  15. Shah J (2003) Head and Neck Surgery and Oncology. 3rd edn. Mosby, St. Louis, MO

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to F. Waldfahrer or M. Wittlinger.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Waldfahrer, F., Iro, H., Fietkau, R. et al. Kopf-Hals-Karzinome. best practice onkologie 3, 4–14 (2008). https://doi.org/10.1007/s11654-008-0052-9

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11654-008-0052-9

Navigation