Il legamento artificiale: dal tutore intrarticolare al sostituto biomimetico

  • Francesco ManfredaEmail author
  • Matteo Tei
  • Giacomo Placella
  • Auro Caraffa
  • Giuliano Cerulli

The artificial ligament: from intrarticular brace to biomimetic substitute


In ACL reconstruction, the search for the ideal transplant still finds too many controversies. The choice of surgeons has always turned towards the biological solution. The history of artificial ligaments has shown continuous failures. LARS is the most successful synthetic graft in recent years but it should be considered as an “intra-articular brace” and should be reserved only to specific indications. Currently, the research is focusing on the “bioactive” ligament: new treatments of terephthalate, in fact, could make these ligaments able to become future biological-like ligaments, overcoming all the limitations of artificial graft.


Conflitto di interesse

Gli autori Francesco Manfreda, Matteo Tei, Giacomo Placella, Auro Caraffa e Giuliano Cerulli dichiarano di non avere alcun conflitto di interesse.

Consenso informato e conformità agli standard etici

Tutte le procedure descritte nello studio e che hanno coinvolto esseri umani sono state attuate in conformità alle norme etiche stabilite dalla dichiarazione di Helsinki del 1975 e successive modifiche. Il consenso informato è stato ottenuto da tutti i pazienti inclusi nello studio.

Human and Animal Rights

L’articolo non contiene alcuno studio eseguito su esseri umani e su animali da parte degli autori.


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Copyright information

© Società Italiana Ortopedici Traumatologi Ospedalieri d’Italia 2019

Authors and Affiliations

  • Francesco Manfreda
    • 1
    Email author
  • Matteo Tei
    • 2
  • Giacomo Placella
    • 3
  • Auro Caraffa
    • 1
  • Giuliano Cerulli
    • 2
  1. 1.Clinica Ortopedica e TraumatologicaUniversità degli Studi di PerugiaPerugiaItalia
  2. 2.I.R.T.A.L. Istituto di Ricerca Traslazionale per l’Apparato LocomotorePerugiaItalia
  3. 3.Clinica Ortopedica e TraumatologicaAzienda Ospedaliera Regione San CarloPotenzaItalia

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