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α-lactalbumin as a modulator of mammary cellular activity

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References

  • Alston-Mills, B.; Thompson, M. P. A theoretical approach to possible biological functions of the milk-whey proteins α-lactalbumin and β-lactoglobulin. Comments Agric. Food Chem. 3:175–208; 1996.

    CAS  Google Scholar 

  • Berliner, L. J.; Meinholtz, D. C.; Hirai, Y.; Mosci, G.; Thompson, M. P. Functional implications resulting from disruption of the calcium-binding loop in bovine α-lactalbumin. J. Dairy Sci. 74:2394–2402; 1991.

    Article  PubMed  CAS  Google Scholar 

  • Bourtourault, M.; Buléon, R.; Sampérez, S.; Jouan, J. Effet des protéines du lactosérum bovin sur la multiplication de cellules cancéreuses humaines. C. R. Soc. Biol. 185:319–323; 1991.

    CAS  Google Scholar 

  • Brodbeck, U.; Ebner, K. E. Resolution of a soluble lactose synthetase into two protein components and solubilization of microsomal lactose synthetase. J. Biol. Chem. 241:762–764; 1966.

    PubMed  CAS  Google Scholar 

  • Ellis, S.; Akers, R. M. The effect of purified whey protein on in vitro cell proliferation. J. Dairy Sci. 76(Suppl.):170; 1993.

    Google Scholar 

  • Ellwood, K. C.; Chatzidakis, C.; Failla, M. L. Fructose utilization by the human intestinal epithelial cell line, Caco-2. Proc. Soc. Exp. Biol. Med. 202:440–446; 1993.

    PubMed  CAS  Google Scholar 

  • Hakansson, A.; Zhivotovsky, B.; Orrenius, S.; Sabharwal, H.; Svanborg, C. Apoptosis induced by a human milk protein. Proc. Natl. Acad. Sci. USA 92:8064–8068; 1995.

    Article  PubMed  CAS  Google Scholar 

  • Humphreys-Beher, M. G.; Schneyer, C. A.; Zelles, T. Alpha-lactalbumin acts as a bimodal regulator of rat parotid acinar cell growth. Biochem. Biophys. Res. Comm. 17:174–181; 1987.

    Article  Google Scholar 

  • LaBarca, C.; Paiger, K. A simple, rapid, and sensitive DNA assay procedure. Anal. Biochem. 102:344–352; 1980.

    Article  PubMed  CAS  Google Scholar 

  • Pitelka, D. R.; The mammary gland. In: Weiss L. (ed) Cell and Tissue Biology. Urban and Schwartzenberg. Baltimore; 1998:877–898.

  • Quarrie, L. H.; Addey, C. V. P.; Wilde, C. J. Local regulation of mammary apoptosis in the lactating goat. Biochem. Soc. Trans. 22:178S; 1994.

    Google Scholar 

  • Quarrie, L. H.; Addey, C. V. P.; Wilde, C. J. Apoptosis in lactating and involuting mouse mammary tissue demonstrated by nick-end DNA labelling. Cell Tissue Res. 281:413–419; 1995.

    PubMed  CAS  Google Scholar 

  • Rejman, J. J.; Oliver, S. P.; Muenchen, R. A.; Tuner, J. D. Proliferation of the MAC-T bovine mammary epithelial cell line in the presence of mammary secretory whey proteins. Cell Biol. Int. Rep. 16:993–1001; 1992.

    Article  PubMed  CAS  Google Scholar 

  • Roberts, A. B.; Anzano, M. A.; Wakefield, L. M.; Roche, N. S.; Stern, D. F.; Spern, M. B. Type B transforming growth factor: a bifunctional regulator of cellular growth. Proc. Natl. Acad. Sci. USA 82:119–123; 1985.

    Article  PubMed  CAS  Google Scholar 

  • Strang, R.; Li, F.; Saurer, S.; Burkhardt, A.; Friis, R. R. Apoptotic cell death and tissue remodelling during mouse mammary gland involution. Development 115:49–58; 1992.

    Google Scholar 

  • Thompson, M. P.; Farrell, Jr., H. M.; Mohanam, S.; Liu, S.; Kidwell, W. R.; Basal, M. P.; Cook, R. G.; Medina, D.; Kotts, C. E.; Bano, M. Identification of human milk α-lactalbumin as a cell growth inhibitor. Protoplasma 167:134–144; 1992.

    Article  CAS  Google Scholar 

  • Thordarson, G.; Ogron, L.; Day, J. R.; Bowens, K.; Fielder, P.; Talamantes, F. Mammary gland development and α-lactalbumin production in hypophysectomized, pregnant mice. Biol. Reprod. 40:517–524; 1989.

    Article  PubMed  CAS  Google Scholar 

  • Topper, Y. J.; Oka, T.; Vonderhaar, B. K. Techniques for studying development of normal mammary epithelial cells in organ culture. In: B. W. O’Malley and J. G. Hardman (ed.) Methods In Enzymology. Vol. 39. Academic Press, Inc., New York; 1975:443–454.

    Google Scholar 

  • Vonderhaar, B. K.; Nakhasi, H. L. Bifunctional activity of epidermal growth factor on α- and κ-casein gene expression in rodent mammary glands in vitro. Endocrinology 119:1178–1184; 1986.

    Article  PubMed  CAS  Google Scholar 

  • Walker, N. I.; Bennett, R. E.; Kerr, J. F. R. Cell death by apoptosis during involution of the lactating breast in mice and rats. Amer. J. Anat. 185:19–32; 1989.

    Article  PubMed  CAS  Google Scholar 

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Alston-Mills, B., Hepler, C.D., Sternhagen, L. et al. α-lactalbumin as a modulator of mammary cellular activity. In Vitro Cell.Dev.Biol.-Animal 34, 747–750 (1998). https://doi.org/10.1007/s11626-998-0026-9

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