Abstract
Wnt signaling pathways represent an evolutionarily highly conserved, intricate network of molecular interactions that regulates various aspects of cellular behavior, including embryonic development and tissue homeostasis. Wnt signaling pathways share the β-catenin-dependent (canonical) and the multiple β-catenin-independent (non-canonical) pathways. These pathways collectively orchestrate a wide range of cellular processes through distinct mechanisms of action. Both the β-catenin-dependent and β-catenin-independent pathways are closely intertwined with microtubule dynamics, underscoring the complex crosstalk between Wnt signaling and the cellular cytoskeleton. This interplay involves several mechanisms, including how the components of Wnt signaling can influence the stability, organization, and distribution of microtubules. The modulation of microtubule dynamics by Wnt signaling plays a crucial role in coordinating cellular behaviors and responses to external signals. In this comprehensive review, we discussed the current understanding of how Wnt signaling and microtubule dynamics intersect in various aspects of cellular behavior. This study provides insights into our understanding of these crucial cellular processes.
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04 March 2024
A Correction to this paper has been published: https://doi.org/10.1007/s11626-024-00887-2
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This work was supported by JSPS KAKENHI Grant Numbers 22700881, 24700980, 15K07054, 19K06664, 22K06226, JP16H06280, and JP22H04926, grants from the Novartis Foundation for the Promotion of Science, the Nakatomi Foundation, the Japan Spina Bifida & Hydrocephalus Research Foundation, the Takeda Science Foundation, Astellas Foundation for Research on Metabolic Disorders, the Mochida Memorial Foundation, and the Uehara Memorial Foundation and the program of the Joint Usage/Research Centre for Developmental Medicine, Institute of Molecular Embryology and Genetics, Kumamoto University (to K.K.), JSPS KAKENHI Grant Numbers 22K15130 and the Takeda Science Foundation (to M.A.).
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Kikuchi, K., Arata, M. The interplay between Wnt signaling pathways and microtubule dynamics. In Vitro Cell.Dev.Biol.-Animal 60, 502–512 (2024). https://doi.org/10.1007/s11626-024-00860-z
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DOI: https://doi.org/10.1007/s11626-024-00860-z