References
Ahn J-Y, Song J-Y, Yun Y-S et al (2006) Protection of Staphylococcus aureus-infected septic mice by suppression of early acute inflammation and enhanced antimicrobial activity by ginsan. FEMS Immunol Med Microbiol 46:187–197. https://doi.org/10.1111/j.1574-695X.2005.00021.x
Angelova N, Kong H-W, van der Heijden R et al (2008) Recent methodology in the phytochemical analysis of ginseng. Phytochem Anal 19:2–16. https://doi.org/10.1002/pca.1049
Barrientos S, Stojadinovic O, Golinko MS et al (2008) Growth factors and cytokines in wound healing. Wound Repair Regen 16:585–601. https://doi.org/10.1111/j.1524-475X.2008.00410.x
Cabral de Oliveira AC, Perez AC, Merino G et al (2001) Protective effects of Panax ginseng on muscle injury and inflammation after eccentric exercise. Comp Biochem Physiol C Toxicol Pharmacol 130:369–377. https://doi.org/10.1016/s1532-0456(01)00262-9
Cho J-S, Moon Y-M, Um J-Y et al (2012) Inhibitory effect of ginsenoside Rg1 on extracellular matrix production via extracellular signal-regulated protein kinase/activator protein 1 pathway in nasal polyp-derived fibroblasts. Exp Biol Med (maywood) 237:663–669. https://doi.org/10.1258/ebm.2012.011342
Choi SY, Cho C-W, Lee Y et al (2012) Comparison of ginsenoside and phenolic ingredient contents in hydroponically-cultivated ginseng leaves, fruits, and roots. J Ginseng Res 36:425–429. https://doi.org/10.5142/jgr.2012.36.4.425
Gordon A, Kozin ED, Keswani SG et al (2008) Permissive environment in postnatal wounds induced by adenoviral-mediated overexpression of the anti-inflammatory cytokine interleukin-10 prevents scar formation. Wound Repair Regen 16:70–79. https://doi.org/10.1111/j.1524-475X.2007.00326.x
Hong C-E, Lyu S-Y (2011) Anti-inflammatory and anti-oxidative effects of Korean red ginseng extract in human keratinocytes. Immune Netw 11:42–49. https://doi.org/10.4110/in.2011.11.1.42
Hwang J-T, Lee M-S, Kim H-J et al (2009) Antiobesity effect of ginsenoside Rg3 involves the AMPK and PPAR-gamma signal pathways. Phytother Res 23:262–266. https://doi.org/10.1002/ptr.2606
Jie YH, Cammisuli S, Baggiolini M (1984) Immunomodulatory effects of Panax Ginseng C.A. Meyer in the Mouse Agents Actions 15:386–391. https://doi.org/10.1007/BF01972376
Kim HA, Kim S, Chang SH et al (2007) Anti-arthritic effect of ginsenoside Rb1 on collagen induced arthritis in mice. Int Immunopharmacol 7:1286–1291. https://doi.org/10.1016/j.intimp.2007.05.006
Kim H-S, Lee E-H, Ko S-R et al (2004) Effects of ginsenosides Rg3 and Rh2 on the proliferation of prostate cancer cells. Arch Pharm Res 27:429–435. https://doi.org/10.1007/BF02980085
Kim SH, Park KS, Chang MJ, Sung JH (2005) Effects of Panax ginseng extract on exercise-induced oxidative stress. J Sports Med Phys Fitness 45:178–182
Kim YS, Cho I-H, Jeong M-J et al (2011) Therapeutic effect of total ginseng saponin on skin wound healing. J Ginseng Res 35:360–367. https://doi.org/10.5142/jgr.2011.35.3.360
Kimura Y, Sumiyoshi M, Kawahira K, Sakanaka M (2006) Effects of ginseng saponins isolated from Red Ginseng roots on burn wound healing in mice. Br J Pharmacol 148:860–870. https://doi.org/10.1038/sj.bjp.0706794
Lee G-Y, Park K-G, Namgoong S et al (2016) Effects of Panax ginseng extract on human dermal fibroblast proliferation and collagen synthesis. Int Wound J 13(Suppl 1):42–46. https://doi.org/10.1111/iwj.12530
Lee SM, Bae B-S, Park H-W et al (2015) Characterization of Korean Red Ginseng (Panax ginseng Meyer): history, preparation method, and chemical composition. J Ginseng Res 39:384–391. https://doi.org/10.1016/j.jgr.2015.04.009
Leung KW, Cheung LWT, Pon YL et al (2007) Ginsenoside Rb1 inhibits tube-like structure formation of endothelial cells by regulating pigment epithelium-derived factor through the oestrogen beta receptor. Br J Pharmacol 152:207–215. https://doi.org/10.1038/sj.bjp.0707359
Leung KW, Pon YL, Wong RNS, Wong AST (2006) Ginsenoside-Rg1 induces vascular endothelial growth factor expression through the glucocorticoid receptor-related phosphatidylinositol 3-kinase/Akt and beta-catenin/T-cell factor-dependent pathway in human endothelial cells. J Biol Chem 281:36280–36288. https://doi.org/10.1074/jbc.M606698200
Li Y, Yang T, Li J et al (2016) Inhibition of multiple myeloma cell proliferation by ginsenoside Rg3 via reduction in the secretion of IGF-1. Mol Med Rep 14:2222–2230. https://doi.org/10.3892/mmr.2016.5475
Liu F-Y, Hsu T-C, Choong P et al (2018) Uncovering the regeneration strategies of zebrafish organs: a comprehensive systems biology study on heart, cerebellum, fin, and retina regeneration. BMC Syst Biol 12:29. https://doi.org/10.1186/s12918-018-0544-3
Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25:402–408. https://doi.org/10.1006/meth.2001.1262
Lu H, Zhou X, Kwok H-H et al (2017) Ginsenoside-Rb1-mediated anti-angiogenesis via regulating PEDF and miR-33a through the activation of PPAR-γ pathway. Front Pharmacol 8:783. https://doi.org/10.3389/fphar.2017.00783
Lu S, Zhang Y, Li H et al (2020) Ginsenoside Rb1 can ameliorate the key inflammatory cytokines TNF-α and IL-6 in a cancer cachexia mouse model. BMC Complement Med Ther 20:11. https://doi.org/10.1186/s12906-019-2797-9
Marques IJ, Lupi E, Mercader N (2019) Model systems for regeneration: zebrafish. Development 146 dev167692 https://doi.org/10.1242/dev.167692
Nguyen-Chi M, Laplace-Builhé B, Travnickova J et al (2017) TNF signaling and macrophages govern fin regeneration in zebrafish larvae. Cell Death Dis 8:e2979. https://doi.org/10.1038/cddis.2017.374
Pakyari M, Farrokhi A, Maharlooei MK et al (2013) Critical role of transforming growth factor beta in different phases of wound healing. Adv Wound Care 2:215–224. https://doi.org/10.1089/wound.2012.0406
Park D, Bae D-K, Jeon JH et al (2011) Immunopotentiation and antitumor effects of a ginsenoside Rg3-fortified red ginseng preparation in mice bearing H460 lung cancer cells. Environ Toxicol Pharmacol 31:397–405. https://doi.org/10.1016/j.etap.2011.01.008
Park J-S, Park E-M, Kim D-H et al (2009) Anti-inflammatory mechanism of ginseng saponins in activated microglia. J Neuroimmunol 209:40–49. https://doi.org/10.1016/j.jneuroim.2009.01.020
Pastar I, Stojadinovic O, Yin NC et al (2014) Epithelialization in wound healing: a comprehensive review. Adv Wound Care (new Rochelle) 3:445–464. https://doi.org/10.1089/wound.2013.0473
Peiser L, Mukhopadhyay S, Gordon S (2002) Scavenger receptors in innate immunity. Curr Opin Immunol 14:123–128. https://doi.org/10.1016/s0952-7915(01)00307-7
Peranteau WH, Zhang L, Muvarak N et al (2008) IL-10 overexpression decreases inflammatory mediators and promotes regenerative healing in an adult model of scar formation. J Invest Dermatol 128:1852–1860. https://doi.org/10.1038/sj.jid.5701232
Qiu X-M, Bai X, Jiang H-F et al (2014) 20-(s)-ginsenoside Rg3 induces apoptotic cell death in human leukemic U937 and HL-60 cells through PI3K/Akt pathways. Anticancer Drugs 25:1072–1080. https://doi.org/10.1097/CAD.0000000000000147
Null Sivamani Garcia Isseroff RKMSRR (2007) Wound re-epithelialization: modulating keratinocyte migration in wound healing. Front Biosci 12:2849–2868. https://doi.org/10.2741/2277
Rumalla VK, Borah GL (2001) Cytokines, growth factors, and plastic surgery. Plast Reconstr Surg 108:719–733. https://doi.org/10.1097/00006534-200109010-00019
Santoro MM, Gaudino G (2005) Cellular and molecular facets of keratinocyte reepithelization during wound healing. Exp Cell Res 304:274–286. https://doi.org/10.1016/j.yexcr.2004.10.033
Shan X, Fu Y-S, Aziz F et al (2014) Ginsenoside Rg3 inhibits melanoma cell proliferation through down-regulation of histone deacetylase 3 (HDAC3) and increase of p53 acetylation. PLoS ONE 9:e115401. https://doi.org/10.1371/journal.pone.0115401
Shin Y-M, Jung H-J, Choi W-Y, Lim C-J (2013) Antioxidative, anti-inflammatory, and matrix metalloproteinase inhibitory activities of 20(S)-ginsenoside Rg3 in cultured mammalian cell lines. Mol Biol Rep 40:269–279. https://doi.org/10.1007/s11033-012-2058-1
Tang M, Wang W, Cheng L, et al. (2018) The inhibitory effects of 20(R)-ginsenoside Rg3 on the proliferation, angiogenesis, and collagen synthesis of hypertrophic scar derived fibroblasts in vitro. Iran J Basic Med Sci 21 309 317 https://doi.org/10.22038/ijbms.2018.19451.5153
Wu H, Chen X, Xiong L (2003) Experimental study of proliferation of Schwann cells cultured with ginsenoside Rb1. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 17:26–29
Wynn TA, Chawla A, Pollard JW (2013) Macrophage biology in development, homeostasis and disease. Nature 496:445–455. https://doi.org/10.1038/nature12034
Wynn TA, Vannella KM (2016) Macrophages in tissue repair, regeneration, and fibrosis. Immunity 44:450–462. https://doi.org/10.1016/j.immuni.2016.02.015
Xia T, Wang Y-N, Zhou C-X et al (2017) Ginsenoside Rh2 and Rg3 inhibit cell proliferation and induce apoptosis by increasing mitochondrial reactive oxygen species in human leukemia Jurkat cells. Mol Med Rep 15:3591–3598. https://doi.org/10.3892/mmr.2017.6459
Xie X-S, Liu H-C, Fan J-M, Li H-J (2009) Effects of ginsenoside Rb1 on TGF-beta1 induced p47phox expression and extracellular matrix accumulation in rat renal tubular epethelial cells. Sichuan Da Xue Xue Bao Yi Xue Ban 40:106–110
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This research was supported by the Natural Sciences and Engineering Research Council of Canada (NSERC)-Discovery Grant Program.
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Shandilya, U.K., Lamers, K., Zheng, Y. et al. Ginsenoside Rb1 selectively improved keratinocyte functions in vitro without affecting tissue regeneration in zebrafish larvae tail regrowth. In Vitro Cell.Dev.Biol.-Animal 58, 269–277 (2022). https://doi.org/10.1007/s11626-022-00664-z
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DOI: https://doi.org/10.1007/s11626-022-00664-z