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Effect of selected dimethylaminochalcones on some mitochondrial activities

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Abstract

Chalcones and their synthetic cyclic analogues have been shown to possess a full scale of biological activities in a variety of experimental systems. They were assessed to be mostly effective in defense against free radicals in the organism, but several compounds exhibited cytotoxic pro-oxidant activities. The respiratory response and antioxidant status in mitochondria were investigated upon addition of 4′-dimethylaminochalcone (1a) and its cyclic analogues, (E)-2-(4′-((CH3)2 N)-benzylidene)-1-indanone (1b), -1-tetralone (1c), and -1-benzosuberone (1d). Selected structures were able to change the respiratory response of mitochondria and showed an ability to modify mitochondrial metabolic and redox efficiency, though they did not indicate redox reactivity towards glutathione in adduct-free incubations. The results of the study indicate that -chalcone and -tetralone derivatives cause suppression of reactive oxygen species affecting mitochondrial respiration by mild uncoupling. In addition, (E)-2-(4′-((CH3)2 N)-indanone (1b), and to a greater extent, -benzosuberone (1d), showed pro-oxidant effects, which partially explain their cytotoxicity.

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Acknowledgments

This study was supported by VEGA grants 1/0624/08 and 1/1236/12 from the Slovak Grant Agency for Science and by the Faculty of Medicine Research Fund (AOK-KA 34039-12/2009), University of Pécs. The authors express special thanks to Zsuzsanna Moravecz (University of Pécs) for her excellent technical assistance.

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Authors and Affiliations

  1. Department of Medical and Clinical Biochemistry, Faculty of Medicine, P. J. Šafárik University in Košice, Tr. SNP 1, 040 66, Košice, Slovak Republic

    Janka Vašková, Ladislav Vaško, Martina Poškrobová, Ivan Kron & Juraj Guzy

  2. Institute of Pharmaceutical Chemistry, Faculty of Medicine, University of Pécs, Rókus u. 2, H-7624, Pécs, Hungary

    Renáta Reisch & Pál Perjési

Authors
  1. Janka Vašková
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  2. Renáta Reisch
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  3. Ladislav Vaško
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  4. Martina Poškrobová
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  5. Ivan Kron
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  6. Juraj Guzy
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  7. Pál Perjési
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Correspondence to Janka Vašková.

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Editor: T. Okamoto

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Vašková, J., Reisch, R., Vaško, L. et al. Effect of selected dimethylaminochalcones on some mitochondrial activities. In Vitro Cell.Dev.Biol.-Animal 49, 354–359 (2013). https://doi.org/10.1007/s11626-013-9600-x

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  • DOI: https://doi.org/10.1007/s11626-013-9600-x

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