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Physiologie de l’éjaculation

The physiology of ejaculation

  • Dossier Thématique / Thematic File
  • Published:
Pelvi-périnéologie

Résumé

Si les données issues de la recherche animale et clinique sont assez claires sur la physiologie de l’érection, les phénomènes physiologiques au cours de l’éjaculation, leur régulation périphérique et centrale restent peu étudiés. Cela contraste avec la forte prévalence des troubles de l’éjaculation chez l’homme, ainsi qu’avec des solutions thérapeutiques pharmacologiques encore peu développées. De récentes données issues de travaux fondamentaux chez le rat suggèrent l’existence d’un centre spinal générateur de l’éjaculation, coordonnant les différents événements physiologiques. La possibilité d’un tel centre chez l’homme est supportée par la possibilité d’induire de manière réflexe une éjaculation chez le patient paraplégique par stimulation mécanique des afférences du nerf dorsal de la verge.

Abstract

Although extensive literature is available concerning the physiology of erection, the physiological events associated with ejaculation, and their peripheral and central regulations are poorly addressed by the scientific community. This is in contrast with a high prevalence of ejaculatory disorders in men as well as very few clinical studies on drugs that act on premature ejaculation. Recent data from basic experiments on rats suggest that a group of spinal neurons may act as a central generator to coordinate the different physiological events during ejaculation. The evidence of such a spinal generator in men is also supported by the possibility of inducing a reflex ejaculation in spinal cord injured patients by mechanical stimulation of the dorsal penile nerve afferences.

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Références

  1. Coolen LM (2005) Neural control of ejaculation. J Comp Neurol 493(1): 39–45

    Article  PubMed  Google Scholar 

  2. James S, Chapple CR, Phillips MI, et al. (1989) Autoradiographic analysis of alpha-adrenoceptors and muscarinic cholinergic receptors in the hyperplastic human prostate. J Urol 142(2 Pt 1): 438–444

    PubMed  CAS  Google Scholar 

  3. Chapple CR, Aubry ML, James S, et al. (1989) Characterization of human prostatic adrenoceptors using pharmacology receptor binding and localisation. Br J Urol 63(5): 487–496

    Article  PubMed  CAS  Google Scholar 

  4. Halata Z, Munger BL (1986) The neuroanatomical basis for the protopathic sensibility of the human glans penis. Brain Res 371(2): 205–230

    Article  PubMed  CAS  Google Scholar 

  5. Wieder JA, Brackett NL, Lynne CM, et al. (2000) Anaesthetic block of the dorsal penile nerve inhibits vibratory-induced ejaculation in men with spinal cord injuries. Urology 55(6): 915–917

    Article  PubMed  CAS  Google Scholar 

  6. Nadelhaft I, de Groat WC, Morgan C (1986) The distribution and morphology of parasympathetic preganglionic neurons in the cat sacral spinal cord as revealed by horseradish peroxidase applied to the sacral ventral roots. J Comp Neurol 249(1): 48–56

    Article  PubMed  CAS  Google Scholar 

  7. Morgan C, de Groat WC, Nadelhaft I (1986) The spinal distribution of sympathetic preganglionic and visceral primary afferent neurons that send axons into the hypogastric nerves of the cat. J Comp Neurol 243(1): 23–40

    Article  PubMed  CAS  Google Scholar 

  8. Schroder HD (1985) Anatomical and pathoanatomical studies on the spinal efferent systems innervating pelvic structures. 1. Organization of spinal nuclei in animals. 2. The nucleus X-pelvic motor system in man. J Auton Nerv Syst 14(1): 23–48

    Article  PubMed  CAS  Google Scholar 

  9. Sonksen J, Biering-Sorensen F, Kristensen JK (1994) Ejaculation induced by penile vibratory stimulation in men with spinal cord injuries. The importance of the vibratory amplitude. Paraplegia 32(10): 651–660

    PubMed  CAS  Google Scholar 

  10. Johnson RD, Hubscher CH (2000) Brainstem microstimulation activates sympathetic fibers in pudendal nerve motor branch. Neuroreport 11(2): 379–382

    Article  PubMed  CAS  Google Scholar 

  11. McKenna KE, Chung SK, McVary KT (1991) A model for the study of sexual function in anesthetized male and female rats. Am J Physiol 261(5 Pt 2): R1276–R1285

    PubMed  CAS  Google Scholar 

  12. Bernabe J, Clement P, Denys P, et al. (2007) Seminal plug expulsion induced by electrical stimulation of the intermesenteric nerve in anesthetized rats. Biol Reprod

  13. Giuliano F, Clement P (2005) Neuroanatomy and physiology of ejaculation. Annu Rev Sex Res 16: 190–216

    PubMed  Google Scholar 

  14. Truitt WA, Coolen LM (2002) Identification of a potential ejaculation generator in the spinal cord. Science 297(5586): 1566–1569

    Article  PubMed  CAS  Google Scholar 

  15. Truitt WA, Shipley MT, Veening JG, Coolen LM (2003) Activation of a subset of lumbar spinothalamic neurons after copulatory behavior in male but not female rats. J Neurosci 23(1): 325–331

    PubMed  CAS  Google Scholar 

  16. Heeb MM, Yahr P (2001) Anatomical and functional connections among cell groups in the gerbil brain that are activated with ejaculation. J Comp Neurol 439(2): 248–258

    Article  PubMed  CAS  Google Scholar 

  17. Heeb MM, Yahr P (2000) Cell-body lesions of the posterodorsal preoptic nucleus or posterodorsal medial amygdale, but not the parvicellular subparafascicular thalamus, disrupt mating in male gerbils. Physiol Behav 68(3): 317–331

    Article  PubMed  CAS  Google Scholar 

  18. Heeb MM, Yahr P (1996) c-Fos immunoreactivity in the sexually dimorphic area of the hypothalamus and related brain regions of male gerbils after exposure to sex-related stimuli or performance of specific sexual behaviors. Neuroscience 72(4): 1049–1071

    Article  PubMed  CAS  Google Scholar 

  19. Leung PC, Whitmoyer DI, Arendash GW, Sawyer CH (1981) Effects of intraventricular norepinephrine on preopticanterior hypothalamic electrical activity in the freelymoving rat: modulation by ovarian steroid hormones. Brain Res 226(1–2): 143–154

    Article  PubMed  CAS  Google Scholar 

  20. Arendash GW, Gorski RA (1983) Effects of discrete lesions of the sexually dimorphic nucleus of the preoptic area or other medial proptic regions on the sexual behavior of male rats. Brain Res Bull 10(1): 147–154

    Article  PubMed  CAS  Google Scholar 

  21. Arendash GW, Gorski RA (1982) Enhancement of sexual behavior in female rats by neonatal transplantation of brain tissue from males. Science 217(4566): 1276–1278

    Article  PubMed  CAS  Google Scholar 

  22. Pehek EA, Thompson JT, Hull EM (1989) The effects of intracranial administration of the dopamine agonist apomorphine on penile reflexes and seminal emission in the rat. Brain Res 500(1–2): 325–332

    Article  PubMed  CAS  Google Scholar 

  23. Clement P, Bernabe J, Denys P, et al. (2007) Ejaculation induced by i.c.v. injection of the preferential dopamine D(3) receptor agonist 7-hydroxy-2-(di-N-propylamino) tetralin in anesthetized rats. Neuroscience 145(2): 605–610

    Article  PubMed  CAS  Google Scholar 

  24. Bazzett TJ, Eaton RC, Thompson JT, et al. (1991) Dosedependent D2 effects on genital reflexes after MPOA injections of quinelorane and apomorphine. Life Sci 48(24): 2309–2315

    Article  PubMed  CAS  Google Scholar 

  25. Warner RK, Thompson JT, Markowski VP, et al. (1991) Micro-injection of the dopamine antagonist cis-flupenthixol into the MPOA impairs copulation, penile reflexes and sexual motivation in male rats. Brain Res 540(1–2): 177–182

    Article  PubMed  CAS  Google Scholar 

  26. Bazzett T, Lumley L, Bitran D, et al. (1992) Male rat copulation following 6-OHDA lesions of the medial preoptic area: resistance to repeated administration and rapid behavioral recovery. Brain Res 580(1–2): 164–170

    Article  PubMed  CAS  Google Scholar 

  27. Giuliano F, Clement P (2006) Serotonin and premature ejaculation: from physiology to patient management. Eur Urol 50(3): 454–466

    Article  PubMed  CAS  Google Scholar 

  28. Tang Y, Rampin O, Calas A, et al. (1998) Oxytocinergic and serotonergic innervation of identified lumbosacral nuclei controlling penile erection in the male rat. Neuroscience 82(1): 241–254

    Article  PubMed  CAS  Google Scholar 

  29. Clement P, Bernabe J, Gengo P, et al. (2007) Supraspinal site of action for the inhibition of ejaculatory reflex by dapoxetine. Eur Urol 51(3): 825–832

    Article  PubMed  CAS  Google Scholar 

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Correspondence to P. Denys.

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Denys, P., Even-Schneider, A., Bensmail, D. et al. Physiologie de l’éjaculation. Pelv Perineol 2, 342–345 (2007). https://doi.org/10.1007/s11608-007-0154-9

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  • DOI: https://doi.org/10.1007/s11608-007-0154-9

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