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Propriétés pharmacologiques de l’oxybutynine sur la fonction vésicale chez la souris

Pharmacological effects of oxybutynin on bladder function in mice

  • Article Original / Original Article
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Pelvi-périnéologie

Résumé

Les antagonistes muscariniques, comme l’oxybutynine, sont le principal traitement pharmacologique actuel pour l’incontinence urinaire par urgenturie. L’objectif de cette étude a été d’évaluer l’activité pharmacologique de l’oxybutynine sur la fonction vésicale chez la souris. Pour cela, nous avons développé des nouveaux modèles expérimentaux nous permettant d’étudier, in vitro, sa puissance antagoniste sur la vessie isolée et in vivo, son urosélectivité au regard des effets sur les glandes salivaires ainsi que ses effets sur le cycle mictionnel en utilisant la technique de cystomanométrie. L’ensemble des résultats présenté est en accord avec ceux publiés chez l’homme. Cette espèce apparaît être un modèle pertinent pour étudier la fonction vésicale.

Abstract

Muscarinic antagonists, such as oxybutynin, provide the most common pharmacological treatments for urge urinary incontinence. The aim of the present study is to evaluate the pharmacological effects of oxybutynin on bladder function in mice. We constructed new experimental models allowing us to study the in vitro antagonistic effects on strips of bladder detrusor smooth muscle, in vivo uroselectivity (effects on vesical pressure and salivary glands), and the effect on micturition cycles using cystometry. Overall, our results agree with previous results reported in studies of humans. Therefore, mice offer an appropriate model to study bladder function.

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  1. Urosphere, Faculté des sciences pharmaceutiques, 35 chemin des Maraichers, F-31062, Toulouse, France

    A. Deba, P. Lluel & S. Polea

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  1. A. Deba
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  2. P. Lluel
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  3. S. Polea
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Correspondence to P. Lluel.

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Deba, A., Lluel, P. & Polea, S. Propriétés pharmacologiques de l’oxybutynine sur la fonction vésicale chez la souris. Pelv Perineol 2, 12–19 (2007). https://doi.org/10.1007/s11608-007-0108-2

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  • DOI: https://doi.org/10.1007/s11608-007-0108-2

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