References
Health Canada. Health products highlights 2021: helping you maintain and improve your health. Ottawa 2022 [updated August. Available from: https://www.canada.ca/content/dam/hc-sc/documents/services/publications/drugs-health-products/health-product-highlights-2021/health-product-highlights-2021-en.pdf.
Patented Medicine Prices Review Board. Annual report 2021. Ottawa; 2022.
Lexchin J. Quality and quantity of data used by Health Canada in approving new drugs. Frontiers in Medicine. 2023;10:1299239.
Lexchin J. Prediction of therapeutic value of new drugs approved by Health Canada from 2011-2020: a cross-sectional study. Journal of the Royal Society of Medicine Open. 2023;14(5).
Chen E, Haslam A, Prasad V. FDA acceptance of surrogate end points for cancer drug approval. JAMA Internal Medicine. 2020;180(6):912-4.
Prasad V, Kim C, Burotto M, Vandross A. The strength of association between surrogate end points and survival in oncology: a systematic review of trial-level meta-analyses. JAMA Internal Medicine. 2015;175(8):1389-98.
Dechartres A, Trinquart L, Boutron I, Ravaud P. Influence of trial sample size on treatment effect estimates: meta-epidemiological study. BMJ Open. 2013;346:f2304.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of Interest:
In 2020–2023, Joel Lexchin received payments for writing a brief on the role of promotion in generating prescriptions for Koski Minsky and from Strategy Institute for being on a panel discussing pharmacare. He is a member of the Board of Canadian Doctors for Medicare. He receives royalties from University of Toronto Press and James Lorimer & Co. Ltd. for books he has written. He is participating in projects funded by the Canadian Institutes of Health Research.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Lexchin, J. Therapeutic Value of Orphan Drugs Approved by Health Canada: A Cross-Sectional Study. J GEN INTERN MED 39, 1276–1279 (2024). https://doi.org/10.1007/s11606-024-08651-8
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11606-024-08651-8