Abstract
Background
Guidelines recommend deintensifying hypoglycemia-causing medications for older adults with diabetes whose hemoglobin A1c is below their individualized target, but this rarely occurs in practice.
Objective
To understand physicians’ decision-making around deintensifying diabetes treatment.
Design
National physician survey.
Participants
US physicians in general medicine, geriatrics, or endocrinology providing outpatient diabetes care.
Main Measures
Physicians rated the importance of deintensifying diabetes medications for older adults with type 2 diabetes, and of switching medication classes, on 5-point Likert scales. They reported the frequency of these actions for their patients, and listed important barriers and facilitators. We evaluated the independent association between physicians’ professional and practice characteristics and the importance of deintensifying and switching diabetes medications using multivariable ordered logistic regression models.
Key Results
There were 445 eligible respondents (response rate 37.5%). The majority of physicians viewed deintensifying (80%) and switching (92%) diabetes medications as important or very important to the care of older adults. Despite this, one-third of physicians reported deintensifying diabetes medications rarely or never. While most physicians recognized multiple reasons to deintensify, two-thirds of physicians reported barriers of short-term hyperglycemia and patient reluctance to change medications or allow higher glucose levels. In multivariable models, geriatricians rated deintensification as more important compared to other specialties (p=0.027), and endocrinologists rated switching as more important compared to other specialties (p<0.006). Physicians with fewer years in practice rated higher importance of deintensification (p<0.001) and switching (p=0.003).
Conclusions
While most US physicians viewed deintensifying and switching diabetes medications as important for the care of older adults, they deintensified infrequently. Physicians had ambivalence about the relative benefits and harms of deintensification and viewed it as a potential source of conflict with their patients. These factors likely contribute to clinical inertia, and studies focused on improving shared decision-making around deintensifying diabetes medications are needed.
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Data Availability
The datasets used in the current study will be available from the corresponding author on reasonable request, after the primary manuscripts are published.
References
ElSayed NA, Aleppo G, Aroda VR, Bannuru RR, Brown FM, Bruemmer D, et al. 13. Older Adults: Standards of Care in Diabetes-2023. Diabetes Care. 2023;46(Supplement_1):S216-S29. doi:https://doi.org/10.2337/dc23-S013.
American Geriatrics Society Expert Panel on Care of Older Adults with Diabetes Mellitus, Moreno G, Mangione CM, Kimbro L, Vaisberg E. Guidelines abstracted from the American Geriatrics Society Guidelines for Improving the Care of Older Adults with Diabetes Mellitus: 2013 update. J Am Geriatr Soc. 2013;61(11):2020-6. doi:https://doi.org/10.1111/jgs.12514.
Conlin PR, Colburn J, Aron D, Pries RM, Tschanz MP, Pogach L. Synopsis of the 2017 U.S. Department of Veterans Affairs/U.S. Department of Defense Clinical Practice Guideline: Management of Type 2 Diabetes Mellitus. Ann Intern Med. 2017;167(9):655-63. doi:https://doi.org/10.7326/M17-1362.
LeRoith D, Biessels GJ, Braithwaite SS, Casanueva FF, Draznin B, Halter JB, et al. Treatment of Diabetes in Older Adults: An Endocrine Society* Clinical Practice Guideline. J Clin Endocrinol Metab. 2019. doi:https://doi.org/10.1210/jc.2019-00198.
Huang ES, Zhang Q, Gandra N, Chin MH, Meltzer DO. The effect of comorbid illness and functional status on the expected benefits of intensive glucose control in older patients with type 2 diabetes: a decision analysis. Ann Intern Med. 2008;149(1):11-9.
Pilla SJ, Schoenborn NL, Maruthur NM, Huang ES. Approaches to Risk Assessment Among Older Patients With Diabetes. Curr Diab Rep. 2019;19(8):59. doi:https://doi.org/10.1007/s11892-019-1172-z.
Lee AK, Lee CJ, Huang ES, Sharrett AR, Coresh J, Selvin E. Risk Factors for Severe Hypoglycemia in Black and White Adults With Diabetes: The Atherosclerosis Risk in Communities (ARIC) Study. Diabetes Care. 2017;40(12):1661-7. doi:https://doi.org/10.2337/dc17-0819.
Lipska KJ, Ross JS, Wang Y, Inzucchi SE, Minges K, Karter AJ, et al. National trends in US hospital admissions for hyperglycemia and hypoglycemia among Medicare beneficiaries, 1999 to 2011. JAMA Intern Med. 2014;174(7):1116-24. doi:https://doi.org/10.1001/jamainternmed.2014.1824.
Action to Control Cardiovascular Risk in Diabetes Study Group, Gerstein HC, Miller ME, Byington RP, Goff DC, Jr., Bigger JT, et al. Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med. 2008;358(24):2545-59. doi:https://doi.org/10.1056/NEJMoa0802743.
Bonds DE, Miller ME, Bergenstal RM, Buse JB, Byington RP, Cutler JA, et al. The association between symptomatic, severe hypoglycaemia and mortality in type 2 diabetes: retrospective epidemiological analysis of the ACCORD study. BMJ. 2010;340:b4909. doi:https://doi.org/10.1136/bmj.b4909.
Lega IC, Campitelli MA, Austin PC, Na Y, Zahedi A, Leung F, et al. Potential diabetes overtreatment and risk of adverse events among older adults in Ontario: a population-based study. Diabetologia. 2021;64(5):1093-102. doi:https://doi.org/10.1007/s00125-020-05370-7.
Pilla SJ, Kraschnewski JL, Lehman EB, Kong L, Francis E, Poger JM, et al. Hospital utilization for hypoglycemia among patients with type 2 diabetes using pooled data from six health systems. BMJ Open Diabetes Res Care. 2021;9(Suppl 1). doi:https://doi.org/10.1136/bmjdrc-2021-002153.
Bloomfield HE, Greer N, Newman D, MacDonald R, Carlyle M, Fitzgerald P, et al. Predictors and Consequences of Severe Hypoglycemia in Adults with Diabetes - A Systematic Review of the Evidence. Washington (DC)2012.
Zhao Y, Kachroo S, Kawabata H, Colilla S, Mukherjee J, Fonseca V, et al. Association between Hypoglycemia and Fall-Related Fractures and Health Care Utilization in Older Veterans with Type 2 Diabetes. Endocr Pract. 2016;22(2):196-204. doi:https://doi.org/10.4158/EP15640.OR.
Cox DJ, Kovatchev B, Vandecar K, Gonder-Frederick L, Ritterband L, Clarke W. Hypoglycemia preceding fatal car collisions. Diabetes Care. 2006;29(2):467-8. doi:https://doi.org/10.2337/diacare.29.02.06.dc05-1836.
Zoungas S, Patel A, Chalmers J, de Galan BE, Li Q, Billot L, et al. Severe hypoglycemia and risks of vascular events and death. N Engl J Med. 2010;363(15):1410-8. doi:https://doi.org/10.1056/NEJMoa1003795.
Barendse S, Singh H, Frier BM, Speight J. The impact of hypoglycaemia on quality of life and related patient-reported outcomes in Type 2 diabetes: a narrative review. Diabet Med. 2012;29(3):293-302. doi:https://doi.org/10.1111/j.1464-5491.2011.03416.x.
Rossi MC, Nicolucci A, Ozzello A, Gentile S, Aglialoro A, Chiambretti A, et al. Impact of severe and symptomatic hypoglycemia on quality of life and fear of hypoglycemia in type 1 and type 2 diabetes. Results of the Hypos-1 observational study. Nutr Metab Cardiovasc Dis. 2019;29(7):736-43. doi:https://doi.org/10.1016/j.numecd.2019.04.009.
McCoy RG, Herrin J, Galindo RJ, Sindhu Swarna K, Umpierrez GE, Hill Golden S, et al. All-cause mortality after hypoglycemic and hyperglycemic emergencies among U.S. adults with diabetes, 2011-2020. Diabetes Res Clin Pract. 2023;197:110263. doi:https://doi.org/10.1016/j.diabres.2023.110263.
Farrell B, Black C, Thompson W, McCarthy L, Rojas-Fernandez C, Lochnan H, et al. Deprescribing antihyperglycemic agents in older persons: Evidence-based clinical practice guideline. Can Fam Physician. 2017;63(11):832-43.
Oktora MP, Kerr KP, Hak E, Denig P. Rates, determinants and success of implementing deprescribing in people with type 2 diabetes: A scoping review. Diabet Med. 2021;38(2):e14408. doi:https://doi.org/10.1111/dme.14408.
Pilla SJ, Meza KA, Schoenborn NL, Boyd CM, Maruthur NM, Chander G. A Qualitative Study of Perspectives of Older Adults on Deintensifying Diabetes Medications. J Gen Intern Med. 2022. doi:https://doi.org/10.1007/s11606-022-07828-3.
Pilla SJ, Jalalzai R, Tang O, Schoenborn NL, Boyd CM, Golden SH, et al. A National Physician Survey of Deintensifying Diabetes Medications for Older Adults With Type 2 Diabetes. Diabetes Care. 2023. doi:https://doi.org/10.2337/dc22-2146.
American Medical Association Physician Masterfile [internet]. American Medical Association [accessed 2022 Sept 8]. Available from: https://www.ama-assn.org/about/masterfile/ama-physician-masterfile.
Radhakrishnan A, Nowak SA, Parker AM, Visvanathan K, Pollack CE. Linking physician attitudes to their breast cancer screening practices: A survey of US primary care providers and gynecologists. Prev Med. 2018;107:90-102. doi:https://doi.org/10.1016/j.ypmed.2017.11.010.
Tseng E, Greer RC, O'Rourke P, Yeh HC, McGuire MM, Albright AL, et al. National Survey of Primary Care Physicians' Knowledge, Practices, and Perceptions of Prediabetes. J Gen Intern Med. 2019;34(11):2475-81. doi:https://doi.org/10.1007/s11606-019-05245-7.
Goyal P, Anderson TS, Bernacki GM, Marcum ZA, Orkaby AR, Kim D, et al. Physician Perspectives on Deprescribing Cardiovascular Medications for Older Adults. J Am Geriatr Soc. 2020;68(1):78-86. doi:https://doi.org/10.1111/jgs.16157.
Garvey KC, Telo GH, Needleman JS, Forbes P, Finkelstein JA, Laffel LM. Health Care Transition in Young Adults With Type 1 Diabetes: Perspectives of Adult Endocrinologists in the U.S. Diabetes Care. 2016;39(2):190-7. doi:https://doi.org/10.2337/dc15-1775.
Kazzazi F, Haggie R, Forouhi P, Kazzazi N, Malata CM. Utilizing the Total Design Method in medicine: maximizing response rates in long, non-incentivized, personal questionnaire postal surveys. Patient Relat Outcome Meas. 2018;9:169-72. doi:https://doi.org/10.2147/PROM.S156109.
Jepson C, Asch DA, Hershey JC, Ubel PA. In a mailed physician survey, questionnaire length had a threshold effect on response rate. J Clin Epidemiol. 2005;58(1):103-5. doi:https://doi.org/10.1016/j.jclinepi.2004.06.004.
West BT, Zhang S, Wagner J, Gatward R, Saw HW, Axinn WG. Methods for improving participation rates in national self-administered web/mail surveys: Evidence from the United States. PLoS One. 2023;18(8):e0289695. doi:https://doi.org/10.1371/journal.pone.0289695.
Greenhalgh T, Jackson C, Shaw S, Janamian T. Achieving Research Impact Through Co-creation in Community-Based Health Services: Literature Review and Case Study. Milbank Q. 2016;94(2):392-429. doi:https://doi.org/10.1111/1468-0009.12197.
American Diabetes Association Professional Practice Committee, Draznin B, Aroda VR, Bakris G, Benson G, et al. 13. Older Adults: Standards of Medical Care in Diabetes-2022. Diabetes Care. 2022;45(Supplement_1):S195-S207. doi:https://doi.org/10.2337/dc22-S013.
Beatty PC, Willis GB. Research Synthesis: The Practice of Cognitive Interviewing. Public Opinion Quarterly. 2007;71(2):287-311. doi:https://doi.org/10.1093/poq/nfm006.
Anderson K, Stowasser D, Freeman C, Scott I. Prescriber barriers and enablers to minimising potentially inappropriate medications in adults: a systematic review and thematic synthesis. BMJ Open. 2014;4(12):e006544. doi:https://doi.org/10.1136/bmjopen-2014-006544.
Williams R. Understanding and interpreting generalized ordered logit models. The Journal of Mathematical Sociology. 2016;40(1):7-20. doi:https://doi.org/10.1080/0022250X.2015.1112384.
Schoenborn NL, Massare J, Park R, Boyd CM, Choi Y, Pollack CE. Assessment of Clinician Decision-making on Cancer Screening Cessation in Older Adults With Limited Life Expectancy. JAMA Netw Open. 2020;3(6):e206772. doi:https://doi.org/10.1001/jamanetworkopen.2020.6772.
Schoenborn NL, Boyd CM, Pollack CE. Physician Attitudes About Using Life Expectancy to Inform Cancer Screening Cessation in Older Adults-Results From a National Survey. JAMA Intern Med. 2022;182(11):1229-31. doi:https://doi.org/10.1001/jamainternmed.2022.4316.
Schoenborn NL, Janssen EM, Boyd C, Bridges JFP, Wolff AC, Xue QL, et al. Older Adults' Preferences for Discussing Long-Term Life Expectancy: Results From a National Survey. Ann Fam Med. 2018;16(6):530-7. doi:https://doi.org/10.1370/afm.2309.
Schoenborn NL, Lee K, Pollack CE, Armacost K, Dy SM, Bridges JFP, et al. Older Adults' Views and Communication Preferences About Cancer Screening Cessation. JAMA Intern Med. 2017;177(8):1121-8. doi:https://doi.org/10.1001/jamainternmed.2017.1778.
Green AR, Aschmann H, Boyd CM, Schoenborn N. Assessment of Patient-Preferred Language to Achieve Goal-Aligned Deprescribing in Older Adults. JAMA Netw Open. 2021;4(4):e212633. doi:https://doi.org/10.1001/jamanetworkopen.2021.2633.
Resnick B. Health promotion practices of older adults: testing an individualized approach. J Clin Nurs. 2003;12(1):46-55; discussion 6. doi:https://doi.org/10.1046/j.1365-2702.2003.00700.x.
Reeve E. Deprescribing tools: a review of the types of tools available to aid deprescribing in clinical practice. J Pharm Pract Res. 2020;50(1):98-107. doi:https://doi.org/10.1002/jppr.1626.
Genere N, Sargis RM, Masi CM, Nathan AG, Quinn MT, Huang ES, et al. Physician perspectives on de-intensifying diabetes medications. Medicine (Baltimore). 2016;95(46):e5388. doi:https://doi.org/10.1097/MD.0000000000005388.
Munshi MN, Slyne C, Segal AR, Saul N, Lyons C, Weinger K. Simplification of Insulin Regimen in Older Adults and Risk of Hypoglycemia. JAMA Intern Med. 2016;176(7):1023-5. doi:https://doi.org/10.1001/jamainternmed.2016.2288.
Pratley RE, Rosenstock J, Heller SR, Sinclair A, Heine RJ, Kiljanski J, et al. Reduced Glucose Variability With Glucose-Dependent Versus Glucose-Independent Therapies Despite Similar Glucose Control and Hypoglycemia Rates in a Randomized, Controlled Study of Older Patients With Type 2 Diabetes Mellitus. J Diabetes Sci Technol. 2018;12(6):1184-91. doi:https://doi.org/10.1177/1932296818776993.
Heller SR, Pratley RE, Sinclair A, Festa A, Kiljanski J, Brusko CS, et al. Glycaemic outcomes of an Individualized treatMent aPproach for oldER vulnerable patIents: A randomized, controlled stUdy in type 2 diabetes Mellitus (IMPERIUM). Diabetes Obes Metab. 2018;20(1):148-56. doi:https://doi.org/10.1111/dom.13051.
Sinclair AJ, Heller SR, Pratley RE, Duan R, Heine RJ, Festa A, et al. Evaluating glucose-lowering treatment in older people with diabetes: Lessons from the IMPERIUM trial. Diabetes Obes Metab. 2020;22(8):1231-42. doi:https://doi.org/10.1111/dom.14013.
Pilla SJ, Shahidzadeh Yazdi Z, Taylor SI. Individualized Glycemic Goals for Older Adults Are a Moving Target. Diabetes Care. 2022;45(5):1029-31. doi:https://doi.org/10.2337/dci22-0004.
Huang ES. Management of diabetes mellitus in older people with comorbidities. BMJ. 2016;353:i2200. doi:https://doi.org/10.1136/bmj.i2200.
HEDIS Measures and Technical Resources [Internet]. Washington, DC: National Committee for Quality Assurance [accessed 2022 Sept 8]. Available from: https://www.ncqa.org/hedis/measures/.
Pogach L, Aron DC. Sudden acceleration of diabetes quality measures. JAMA. 2011;305(7):709-10. doi:https://doi.org/10.1001/jama.2011.153.
Caverly TJ, Fagerlin A, Zikmund-Fisher BJ, Kirsh S, Kullgren JT, Prenovost K, et al. Appropriate Prescribing for Patients With Diabetes at High Risk for Hypoglycemia: National Survey of Veterans Affairs Health Care Professionals. JAMA Intern Med. 2015;175(12):1994-6. doi:https://doi.org/10.1001/jamainternmed.2015.5950.
Pilla SJ, Segal JB, Maruthur NM. Primary Care Provides the Majority of Outpatient Care for Patients with Diabetes in the US: NAMCS 2009-2015. J Gen Intern Med. 2019;34(7):1089-91. doi:https://doi.org/10.1007/s11606-019-04843-9.
Funding
This study was funded by a grant from the U.S. Deprescribing Research Network, funded by the National Institute on Aging (1R24AG064025). Dr. Pilla was supported by the Johns Hopkins KL2 Clinical Research Scholars Program (KL2TR003099) and the National Institute of Diabetes and Digestive and Kidney Diseases (K23DK128572). Dr. Schoenborn was supported by the National Institute on Aging (K76AG059984). Dr. Boyd was also supported by the U.S. Deprescribing Research Network (R24AG064025) and by K24AG056578, both from the National Institute on Aging. Dr. Mathioudakis was supported by the NIDDK (R01DK125780).
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S.J.P contributed to the study design, data acquisition, analysis, and discussion, and wrote the manuscript. R.J. contributed to data acquisition and background research, and reviewed and edited the manuscript. N.L.S., C.M.B., N.N.M., and N.M.M. contributed to study design, analysis, and discussion, and reviewed and edited the manuscript. O.T. and M.P.B. contributed to analysis and discussion, and reviewed and edited the manuscript. All the authors approved the final version of the manuscript. S.J.P. is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
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Dr. Pilla received honoraria from the American Diabetes Association (ADA) for speaking at the ADA 2022 Scientific Sessions, the ADA 2023 Clinical Update Conference; for authoring the ADA Making Technology Work module on hypoglycemia; and for reviewing the ADA Diabetes Is Primary CE Certificate program. Dr. Boyd received honoraria for writing a chapter on Multiple Chronic Conditions for UpToDate, and a chapter on Falls in Older Adults for DynaMed.
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Pilla, S., Jalalzai, R., Tang, O. et al. A National Survey of Physicians’ Views on the Importance and Implementation of Deintensifying Diabetes Medications. J GEN INTERN MED 39, 992–1001 (2024). https://doi.org/10.1007/s11606-023-08506-8
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DOI: https://doi.org/10.1007/s11606-023-08506-8