Growth in the US population of older adults places an increasing number of people at risk of developing dementia. Most, but not all, studies report an increase in dementia incidence with each successive age group.1 Results have also been inconsistent regarding whether incidence of dementia varies between men and women of the same age. Although the incidence of dementia is higher for similarly aged black than white adults,2 whether age-adjusted incidence differs between other racial/ethnic groups remains unclear.3 Prior epidemiological studies on age of incidence of dementia have been hindered by relatively small in-person assessed samples4 or larger claims-based cohorts that are not nationally representative.3 The objective of this analysis was to estimate the incidence of clinical dementia diagnoses by single year of age, overall and stratified by gender and race/ethnicity by examining clinical administrative claims from a large national Medicare population.
Administrative data from a 50% random national sample of Medicare beneficiaries aged 65–100 years with fee-for-service and Part D prescription drug coverage (2007–2017) were used to identify incident dementia diagnoses (≥ 2 outpatient or ≥ 1 inpatient) among persons 66 to 100 years of age. Incident dementia was defined by a first observed qualifying code from the CMS Chronic Condition Warehouse algorithm for Alzheimer’s disease and related disorders or senile dementia following ≥ 12 consecutive months of Medicare eligibility without a qualifying code. As compared with in-person assessments of cognitive impairment, this claims-based definition has a sensitivity of 85.5%, specificity of 85.9%, and kappa of 0.70.5 Incident dementia diagnoses were plotted by single year of age for the overall sample and separately by gender and major racial/ethnic groups. The Institutional Review Board of Rutgers University approved this study with a waiver of informed consent.
Among 8,106,150 adult Medicare beneficiaries contributing 40,250,286 years of follow-up, the annual incidence of dementia diagnoses per 1000 person-years increased from 7.6 (95%CI 7.5–7.7) for adults aged 66 years to 159.6 (95%CI 155.7–163.5) for adults 100 years of age. For men, the increase in incidence per 1000 person-years was from 8.3 (95%CI 8.1–8.4) for adults aged 66 years to 142.4 (95%CI 132.7–152.1) for adults aged 100 years and for women the increase was from 7.2 (95%CI 7.1–7.2) to 162.7 (95%CI 158.5–167.0) per 1000 person-years (Fig. 1). The annual incidence of dementia diagnosis per 1000 person-years increased among adults aged 66 to 100 years for Asian/Pacific Islanders from 6.0 (95%CI 5.5–6.4) to 142.1 (95%CI 118.3–166.0), for non-Hispanic whites from 6.7 (95%CI 6.6–6.7) to 156.5 (95%CI 152.3–160.7), for Hispanics from 11.1 (95%CI 10.7–11.5) to 191.6 (95%CI 168.9–214.4), and for non-Hispanic blacks from 16.3 (95%CI 16.0–16.7) to 180.7 (95%CI 166.1–195.3) (Fig. 2).
The risk of receiving a clinical dementia diagnosis increased with each successive year of life until age 98. As compared with women, men had a higher incidence of dementia diagnosis before age 70 and a lower incidence thereafter. A greater risk among women starting in the eighth decade of life might be related to selective survival of men with healthier cardiovascular risk profiles, sex differences in educational attainment, sex hormone exposures, or other factors. Consistent with prior research, non-Hispanic black adults had a higher incidence of dementia than non-Hispanic white adults,2 a difference that might be related to variation in vascular health or socioeconomic risk factors. A higher incidence of dementia diagnoses among Hispanic than non-Hispanic white or Asian/Pacific Islander adults highlights the need for research aimed at discovering determinants of these differences including contributions of genetic factors, such as the apolipoprotein E ε4 allele, environmental factors, and gene by environment interactions.
Limitations include that most but not all older US adults enroll in fee-for-service Medicare with prescription coverage; adults first diagnosed prior to age 66 years were not included in this analysis; heterogeneity within racial/ethnic groups; some older adults with dementia may not receive timely diagnoses; and potential misclassification of dementia status due to differences in access to specialty care across gender and racial/ethnic groups. Cultural differences in expectations of healthy aging may also contribute to racial/ethnic and gender differences in the clinical diagnosis of dementia.
Age-specific incidence of clinical dementia diagnosis varies by gender and race/ethnicity. Beyond estimating the clinical and societal burden of dementia, Medicare claims data might also inform the evaluation of clinical and public health initiatives to reduce the incidence of dementia.
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This work is supported by NIMH P50 MH115843 (Dr. Stroup).
The Institutional Review Board of Rutgers University approved this study with a waiver of informed consent.
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The authors declare that they do not have a conflict of interest.
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Olfson, M., Stroup, T.S., Huang, C. et al. Age and Incidence of Dementia Diagnosis. J GEN INTERN MED 36, 2167–2169 (2021). https://doi.org/10.1007/s11606-020-05895-y