Comparing Outcomes and Costs of Medical Patients Treated at Major Teaching and Non-teaching Hospitals: A National Matched Analysis



Teaching hospitals typically pioneer investment in new technology and cultivate workforce characteristics generally associated with better quality, but the value of this extra investment is unclear.


Compare outcomes and costs between major teaching and non-teaching hospitals by closely matching on patient characteristics.


Medicare patients at 339 major teaching hospitals (resident-to-bed (RTB) ratios ≥ 0.25); matched patient controls from 2439 non-teaching hospitals (RTB ratios < 0.05).


Forty-three thousand nine hundred ninety pairs of patients (one from a major teaching hospital and one from a non-teaching hospital) admitted for acute myocardial infarction (AMI), 84,985 pairs admitted for heart failure (HF), and 74,947 pairs admitted for pneumonia (PNA).


Treatment at major teaching hospitals versus non-teaching hospitals.

Main Measures

Thirty-day all-cause mortality, readmissions, ICU utilization, costs, payments, and value expressed as extra cost for a 1% improvement in survival.

Key Results

Thirty-day mortality was lower in teaching than non-teaching hospitals (10.7% versus 12.0%, difference = − 1.3%, P < 0.0001). The paired cost difference (teaching − non-teaching) was $273 (P < 0.0001), yielding $211 per 1% mortality improvement. For the quintile of pairs with highest risk on admission, mortality differences were larger (24.6% versus 27.6%, difference = − 3.0%, P < 0.0001), and paired cost difference = $1289 (P < 0.0001), yielding $427 per 1% mortality improvement at 30 days. Readmissions and ICU utilization were lower in teaching hospitals (both P < 0.0001), but length of stay was longer (5.5 versus 5.1 days, P < 0.0001). Finally, individual results for AMI, HF, and PNA showed similar findings as in the combined results.

Conclusions and Relevance

Among Medicare patients admitted for common medical conditions, as admission risk of mortality increased, the absolute mortality benefit of treatment at teaching hospitals also increased, though accompanied by marginally higher cost. Major teaching hospitals appear to return good value for the extra resources used.


Studies have previously examined the relationship between hospital teaching status and patient outcomes across a range of medical conditions and surgical procedures.1,2,3,4,5,6,7,8,9 Understanding the value of teaching hospitals is important, because they often invest more than non-teaching hospitals in cutting-edge technology and workforce characteristics generally associated with better quality, but typically, this comes with additional cost.1 In order to better quantify the impact of this investment in care for medical patients, we use new methods of multivariate matching10 that closely control for patient differences and compare outcomes and costs on a national scale between teaching and non-teaching hospitals among patients admitted for three common and representative medical conditions that rank among the 10 leading causes of hospitalization (acute myocardial infarction, heart failure, and pneumonia).11 Matching ensures that comparisons between teaching and non-teaching hospitals use pairs of similar patients who have both comparable risk levels on admission and also have that risk for comparable reasons, unlike in regression models where two patients can have similar expected risk due to very different comorbidities or risk factors. Through matching, we can assess whether differences in patient outcomes vary significantly within particular subsets of patients or whether outcomes systematically change as patient risk increases, a concept we call risk synergy.12,13,14 By comparing costs and outcomes, we can learn whether specific patient groups fare better at major teaching or non-teaching hospitals and generate essential data points for assessing comparative value (cost per 1% improvement in survival)—crucial for better referral of patients to hospitals and for implementing value-based payments.15


This research study was approved by the Children’s Hospital of Philadelphia Institutional Review Board.

Patient Population

We were granted access via the Centers for Medicare & Medicaid Services (CMS) Virtual Research Data Center (VRDC) to administrative claims data for older Medicare beneficiaries admitted to short-term acute care hospitals in the USA for principal diagnoses of acute myocardial infarction (AMI), heart failure (HF), or pneumonia (PNA) between July 1, 2012, and November 30, 2014. The VRDC hosted each patient’s beneficiary summary file and administrative claims (inpatient, outpatient, carrier/part B, and hospice files). We excluded hospitalizations if the patient was under 65.5 years old at admission, had evidence of hospice care, or lacked fee-for-service Medicare in the 6 months prior to admission, the month of admission, or the month after admission. If a patient had multiple qualifying admissions during the study period, we randomly chose one. After applying these restrictions, we randomly split the sample to use 90% for matching, with the remaining 10% set aside to create baseline prognostic scores.16 Details of the sample construction, code lists, and sample means are provided in Appendix Tables 1, 2, and 3.


Hospital teaching status was defined using resident-to-bed (RTB) ratios from the Medicare Healthcare Cost Report Information System (HCRIS).17 The focal group of major teaching hospitals was defined as having RTB ratios of 0.25 or greater.18,19 The comparison group of non-teaching hospitals was those with RTB ratios below 0.05.

Patient characteristics were defined using the index admission claim and a 6-month look-back in inpatient, outpatient, carrier/part B, and hospice files. We also defined patient age at admission, year of admission, sex, race, emergent admission type, and encounters at dialysis facilities, skilled nursing facilities, ambulatory surgical centers, and intermediate care facilities, or transfer from another hospital’s inpatient or emergency department immediately preceding admission to the index hospital. Transferred patients’ outcomes were assigned to the first hospital the patient encountered, either as an inpatient or via the emergency department. Comorbidities were defined using methods adapted from CMS.20,21 We also defined 5 geographic regions based on the location of the hospital and estimated a propensity score for admission to a major teaching hospital using all the matching covariates.22,23

To calculate patient risk on admission, we fit binary logistic models predicting probability of 30-day death and ICU use with the 10% sample reserved for risk modeling (see Appendix Tables 4, 5, and 6).24 We divided patients in each of the three medical conditions into five quintiles of predicted 30-day mortality. Predicted length of stay and predicted resource-based hospitalization cost were also modeled with the 10% sample using robust regression.25,26,27

Hospital bed size was defined using the total bed count from HCRIS. We defined each hospital’s nurse-to-bed (NTB) ratio, nurse mix, and technology level using the Medicare Provider of Services file.14,28 Comprehensive cardiac technology was defined as the availability of open-heart surgery and the presence of both a coronary care unit and a catheterization lab.21,29


The primary quality outcome was 30-day all-cause, all-location mortality. We also studied all-cause, all-location readmission or death extending up to 30 days after discharge, with patients who died in the hospital also counted as readmissions. As a stability analysis, we calculated 30-day post-discharge readmission rates in those that survived to discharge. We also examined length of stay and ICU rate of utilization.

We assessed hospital economic performance from the perspective of the health care system using 30-day resource utilization–based cost,14,30,31 which represents resources consumed by the health care system in providing care, and acute-care payments tracked by CMS, which represent payments made to the health care system by Medicare, patients, and other primary payers. Resource utilization–based costs track resources through a standardized national price index and do not reflect prices charged to patients or payers. Thirty-day resource costs counted index hospitalization costs plus costs from emergency department, outpatient, or office visits within 30 days of admission, and all costs associated with readmissions that began within 30 days of the index admission date. See Appendix Table 8 for the costing algorithm.

Acute-care payments reflect the amount actually paid for the hospitalization. We focused on two payment calculations. The first was actual payment as tracked in the CMS claims, which includes all payments made by CMS, the beneficiary, and any other third-party payer. The second payment calculation removes Medicare’s adjustments for geography, disproportionate share hospital (DSH), and indirect medical expenditure (IME) payments.32 See Appendix Table 8 for details. As a stability analysis, we repeated all analyses of cost and payment with alternate definitions that added post-acute-care payments.5

Defining Value

We defined value (sometimes referred to as incremental cost-effectiveness) as the difference in resource utilization cost between major teaching and non-teaching matched pairs, divided by the difference in 30-day mortality between major teaching and non-teaching matched pairs (or Δ cost/Δ mortality). Neumann et al.33 suggest acceptable ratios between $100 and $200,000 per life year saved in the USA. We then repeated these value calculations adding post-acute-care payments. We report value as the cost (or payment) increase associated with a 1% improvement in mortality if the ratio’s denominator was defined (i.e., significantly different from zero); readers familiar with the cost-per-life-saved metric can obtain it by multiplying our estimate by 100. The 95% confidence interval for the value ratio was derived using the jackknife.34

Statistical Methods

Matching Methodology

Matching of major teaching cases to non-teaching controls was accomplished using the NetFlow procedure in SAS.35 Patients were matched exactly for principal diagnosis category and quintile of 30-day mortality risk. Within exact groups, we used near-exact matching36 with refined balance10 to control for hospital region. We also used refined balance to match patient demographics, admission characteristics, and risk factors. Subject to the exact and refined balance constraints, we optimally formed the closest sets of pairs between cases and controls by minimizing a Mahalanobis distance37 between cases and controls, which included all comorbidities, demographic, and admission characteristics, the risk scores, and a propensity score for admission to a major teaching hospital (see Appendix Tables 7a–7c). The AMI and HF matches each included 68 covariates, while the pneumonia match included 76 covariates.

Matching was performed first without viewing outcomes.38 We aimed to attain standardized differences in covariate means below 0.1 standard deviations after matching, though below 0.2 is a traditional standard.39,40 We also assessed balance using 2-sample randomization tests, specifically the Wilcoxon rank-sum test for each continuous covariate and Fisher’s exact test for each binary one, thereby comparing the balance achieved by matching to the balance expected from complete randomization.41

Comparing Outcomes

Outcomes were compared using paired methods: for binary outcomes, McNemar’s test;42 for continuous outcomes, M-statistics for matched pairs.26,43,44,45 We further compared outcomes between major teaching patients and non-teaching controls within each risk quintile. Trends across risk levels were assessed using the Mantel test for trend for binary outcomes46 and robust regression for continuous outcomes.26,27 Graphs of major-minus-nonteaching outcome differences by risk level were produced using the LOWESS procedure in SAS,47 using smoothed pointwise 95% bootstrapped confidence intervals.48


Final Patient and Hospital Sample

The sample comprised 203,922 patients treated for AMI, HF, or PNA at 339 major teaching hospitals and 1,049,037 patients treated at 2533 non-teaching hospitals. All major teaching hospitals and their patients were used in the match, while 2439 non-teaching hospitals (96.3%) were represented in the match.

As expected, the structural features of teaching hospitals differed from non-teaching hospitals in many ways, as seen in Table 1, with more teaching hospitals with high-level cardiac technology and higher nurse-to-bed ratios.

Table 1 Combined AMI, HF, and PNA Matching Results

The Quality of the Patient Matches

To illustrate the quality of matching, Table 1 displays a few details of the combined AMI, HF, and PNA matches. Not seen in Table 1 are the 5 risk quintiles that were matched exactly within pairs, and the complete list of 26 demographic covariates and 29 comorbid conditions that were matched. Before matching, teaching hospital cases and non-teaching hospital controls differed in many ways. For example, teaching hospital patients were admitted with higher rates of HF, higher rates of chronic kidney disease, and higher rates of diabetes, while non-teaching controls were more likely to be non-Hispanic whites and have higher rates of COPD. After matching, all clinical covariate standardized differences met the balance criteria of 0.10 SDs or less. All covariates within the individual AMI, HF, and PNA matches also met the balance criteria on all covariates. Complete matching tables are displayed in Appendix Tables 9–9c.

Outcome Results

Table 2 reports outcome results for the combined medical match, as well as separately for AMI, HF, and PNA and within the five quintiles of risk. The overall 30-day mortality rate for the 3 medical conditions combined was 10.7% at major teaching hospitals, compared to 12.0% at non-teaching hospitals (difference = − 1.3%, P < 0.0001). Major teaching hospitals used the ICU less frequently than non-teaching hospitals (19.9% vs. 22.4%, difference = − 2.5%, P < 0.0001). Length of stay was longer at teaching hospitals (5.5 days vs. 5.1 days, paired difference = 0.4, P < 0.0001), but 30-day readmission or death was lower (30.4% vs. 32.3%, difference = − 1.9%, P < 0.0001). A stability analysis examining 30-day readmission in patients who survived to discharge displayed similar results, except for the highest severity patients in quantile 5, where teaching hospitals appeared to have higher readmissions than non-teaching hospitals when ignoring differential death rates (see Appendix Table 10). Thirty-day resource utilization costs were $19,249 versus $18,944 (a paired difference of $273, P < 0.0001). Thirty-day total acute-care payments were $22,304 versus $17,141 (a paired difference of $5048, P < 0.0001); however, after removing geography, DSH, and IME payments, 30-day acute-care payments were $17,902 versus $16,207 (a paired difference of $1662, P < 0.0001). See Appendix Tables 11–11c for other forms of payment calculations. Results for the individual medical conditions were similar.

Table 2 Combined Acute Myocardial Infarction, Heart Failure, and Pneumonia Outcomes, Costs, and Value by Hospital Type and Patient Risk on Admission

Differences in Outcomes and Costs Across Patient Risk Levels

The last 6 columns of Table 2 report outcome differences for the combined medical group by ascending risk quintiles (risk synergy) and summary tests for trend. We found increasing mortality reductions at major teaching hospitals with increasing risk on admission. There was no difference in mortality in the lowest-risk quintile (2.5% vs. 2.6%, difference = − 0.1%, P = 0.4670), but a large difference for the highest-risk quintile (24.6% vs. 27.6%, difference = − 3.0%, P < 0.0001) (trend P = 0.0001), and a patient cost difference of $16,464 versus $17,000 (paired difference = − $546, P < 0.0001) in the lowest-risk quintile and a patient cost difference of $22,265 versus $20,901 (paired difference = $1289, P < 0.0001) in the highest-risk quintile (trend P < 0.0001).

Figure 1a, b, and c display the relationship between escalating mean patient risk on admission in matched pairs on the x-axis and the difference in 30-day mortality between the matched pairs on the y-axis, and similarly, Figure 2a, b, and c display the differences in cost. The central curve in each figure shows the paired difference in outcome rate at the risk level indicated on the x-axis, and the shaded region represents the pointwise 95% confidence interval from the bootstrap. Points below zero for the y-axis suggest lower mortality or cost in the teaching hospital patients for a given risk level.

Figure 1

AMI (a), HF (b), and PNA (c) Risk Synergy LOWESS plots of difference in mortality between matched pairs (teaching − non-teaching) versus risk of 30-day mortality on admission. The central curve shows the paired difference in outcome rate as risk level escalates, and the shaded region represents the pointwise 95% confidence interval from the bootstrap. Below each graph is a boxplot of the distribution by a matched pair of average risk of mortality on admission, with whiskers extending to the 5th and 95th percentiles.

Figure 2

AMI (a), HF (b), and PNA (c) Risk Synergy LOWESS plots of difference in resource utilization (cost) between matched pairs (teaching − non-teaching) versus risk of 30-day mortality on admission. The central curve shows the paired difference in outcome rate as risk level escalates, and the shaded region represents the pointwise 95% confidence interval from the bootstrap. Below each graph is a boxplot of the distribution by a matched pair of average risk of mortality on admission, with whiskers extending to the 5th and 95th percentiles.

We also saw significant trends (in both directions) in all outcomes between major teaching and non-teaching patients, except for length of stay and ICU use. Notably, teaching hospitals consistently used the ICU at lower rates than non-teaching hospitals.

Estimates of Comparative Value

Table 2 also provides estimates of the difference in cost for a 1% difference in mortality between major teaching and non-teaching hospitals, with associated 95% CIs. We also examine value within risk quintile and again provide condition-specific value estimates in Appendix Tables 12–12c.

Tracking price-standardized resource utilization costs, the value estimate for combined medical conditions was $211 for a 1% reduction in mortality at the major teaching hospitals compared to non-teaching hospitals, or equivalently $21,100 per life saved. Similar results were seen within the individual medical conditions. For the lowest-risk patients, costs were significantly lower at major teaching hospitals, but mortality was not significantly different between hospital types. In the highest-risk quintile, we found a value estimate of $427 per 1% reduction in mortality. A stability analysis incorporating post-acute-care costs from all sources displayed very similar results (see Appendix Table 13 for both costs and payments).

Examining total acute-care payments, the overall payment difference for the combined medical conditions was $5048 with an associated mortality reduction of − 1.3%, resulting in an incremental cost-effectiveness ratio point estimate of $3904 per 1% reduction in mortality. However, removing Medicare payment adjustments for geography and DSH (which would be paid to any hospital in the same location serving the same population) and removing the indirect medical education adjustment (because payments to support medical education are needed to supply future practicing physicians for both teaching and non-teaching hospitals), the payment difference was $1662, translating to a value estimate of $1286 per 1% reduction in mortality. For the highest-risk patients, the value estimate using total payments was $2030. However, after removing geographic, IME, and DSH payments, the highest-risk quintile had a value estimate of $809.


Risk Synergy is the phenomenon where increasing patient risk on admission interacts with hospital type12,13,14 to influence outcomes. In this study, as patients presented with poorer health, they experienced increasing 30-day mortality benefit of treatment at major teaching hospitals relative to non-teaching hospitals. A similar finding was observed in our earlier work concerning different nursing environments14 and also was recently reported in a study by Burke et al.7 The present study builds on the work of Burke et al.5,7,8 by examining concomitant costs, and value, showing increasing differences in resource utilization costs between teaching and non-teaching hospitals as risk increased, co-occurring with increasing differences in mortality and better value. Major teaching hospitals required fewer resources to treat low-risk patients than non-teaching hospitals did, but as patient risk increased, resource costs at major teaching hospitals increased above those in non-teaching hospitals. In general, however, costs were higher at major teaching hospitals, in part because length of stay was consistently longer across risk levels, and because of the higher resource utilization at teaching hospitals in the highest risk patients compared to non-teaching hospitals.

For the lowest-risk patients in the combined analysis, mortality was not different between hospital types, but cost was typically lower at teaching hospitals. In the second-lowest risk quintile, both mortality and cost were significantly lower at teaching hospitals—a clear indication of accruing value at the teaching hospitals. From the middle quintile to the highest-risk quintile, we observed significantly lower mortality at the teaching hospitals, but also higher costs. By the highest quintile of risk, there was a − 3.0% absolute difference in mortality at major teaching hospitals, with an associated $1289 cost increase. In our value calculation, that translates to about $427 per 1% increase in survival.

While a more traditional value calculation of differences in lives saved is useful to policymakers who want to know the statistical cost for one life saved over a population, the information should be interpreted differently by patients. Patients cannot pay $42,700 for a 100% reduction in their risk of death. Rather, the individual patient may want to think about value as the incremental cost for, say, a 1% absolute reduction in the risk of death.

For both teaching and non-teaching hospitals, it appears that as patient risk increased, resource utilization (cost) increased, but payments were relatively stable. This could represent a cross-subsidization that occurs between low- and high-risk patients at both types of hospitals.

Overall, we found a − 1.3% absolute reduction in mortality at major teaching hospitals (10.7% vs. 12.0%) compared to non-teaching hospitals, consistent with a report by Burke et al.,8 who found a similar difference in 30-day mortality in national Medicare data with regression modeling. Our analysis also examined resource costs and payments, and the cost-to-quality trade-off along the continuum of patient risk. In so doing, we found that even though resource costs and payments increased at teaching hospitals relative to non-teaching hospitals as patient risk increased, the concomitantly increasing quality benefit associated with lower mortality resulted in good value. While other studies have compared quality and cost between teaching and non-teaching hospitals,3,7,8,9 all such studies fundamentally depend on the specifications of the regression model to make an unbiased comparison between hospital groups whose patients may differ substantially in characteristics and risk. Using matching, we could assure that risk subsets of our analysis compared similar patients with similar diagnoses, thereby allowing us to better understand differential outcomes across and within levels of risk.

Recent work by Burke et al.,5,7,8 and summarized in an editorial on value by Khullar et al.,6 did not actually estimate value between hospital types. Our study estimated value differences between teaching and non-teaching hospitals, by summarizing the cost differences across a group of matched pairs, and the mortality differences across the same patients included in the matched pairs, and calculated value, again using those same patients. The methods we described also allowed us to place a confidence interval around all of these quantities.

Our study has implications for practice and policy. Treatment capacity in major teaching hospitals is limited, and our study shows that although complex, high-risk patients are currently treated at both major and non-teaching hospitals, major teaching hospitals provide superior outcomes for such patients at only a slight fiscal premium, providing good value. The health system could use this information to promote a more optimal, efficient allocation of patients to academic hospitals, based on both their own needs and the differential capacity of facilities to address them. We also now provide a quality context to differential payments, which is important knowledge for setting reimbursement policy.

Our study is based on Medicare claims, with all of the limitations associated with such administrative data, including the possibility of confounders not measured in claims. Administrative data also lacks information on quality of life or non-medical costs to patients that would have improved comparisons of cost-effectiveness.

In brief, for comparable patients, 30-day mortality was lower at teaching hospitals for AMI, HF, and PNA, with larger differences for high-risk patients. The cost of treating lower-risk patients was lower at teaching hospitals, while higher-risk patients accrued higher costs at teaching hospitals but had significantly better outcomes, suggesting that extra resources used at major teaching versus non-teaching hospitals represented good value.


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We thank Traci Frank, AA; Kathryn Yucha, MSN, RN; and Sujatha Changolkar (Center for Outcomes Research, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA) for their assistance with this research.

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Correspondence to Jeffrey H. Silber MD, PhD.

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This research was funded by a grant from the Association of American Medical Colleges (AAMC) to study differences between teaching and non-teaching hospitals on outcomes, costs and value. AAMC had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, and approval of the manuscript; or decision to submit the manuscript for publication.

The authors declare that the Children’s Hospital of Philadelphia (CHOP) and the University of Pennsylvania (PENN) received a research grant from the Association of American Medical Colleges (AAMC) which, in turn, provided partial salary support for some investigators.

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Silber, J.H., Rosenbaum, P.R., Niknam, B.A. et al. Comparing Outcomes and Costs of Medical Patients Treated at Major Teaching and Non-teaching Hospitals: A National Matched Analysis. J GEN INTERN MED 35, 743–752 (2020).

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  • Medicare
  • value
  • teaching hospitals
  • mortality
  • cost