Associations of Diabetes Genetic Risk Counseling with Incident Diabetes and Weight: 5-Year Follow-up of a Randomized Controlled Trial
Despite advances in understanding the genetics of type 2 diabetes (T2D), the benefits of precision medicine—better disease risk prediction and individually tailored prevention or treatment—remain aspirational. While patients have reported that genetic risk information would motivate preventive health behavior change,1, 2 this has not been borne out in short-term studies of genetic risk counseling.3, 4 The adoption of risk-modifying behaviors may be delayed as patients accumulate T2D risk factors and learn behavior change skills. We report the 5-year follow-up results of a randomized genetic risk counseling intervention on incident T2D and weight in a population of adults with elevated diabetes risk.
The randomized clinical trial has been described.3 Briefly, 601 adults aged 21–65 years with body mass index (BMI) ≥ 27 kg/m2, not actively losing weight, and receiving primary care at the Durham Veterans Affairs (VA) Medical Center were randomized to receive...
All authors contributed to study design and analysis plan development. Data were collected by CIV, CJC, DE, and KX; KX and CJC performed all analyses; all authors contributed to the interpretation of results, as well as drafting and critical revision of the manuscript.
SR is supported by the American Heart Association award 17MCPRP33670728 and US Department of Veterans Affairs (VA) award IK2-CX001907-01. CIV is supported by a Research Career Scientist award from the VA Health Services Research & Development service (RCS 14-443).
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Conflict of Interest
The authors declare that they do not have a conflict of interest.
The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript. This work is not intended to reflect the official opinion of the US Department of Veterans Affairs, the National Institutes of Health, or the US government.