Associations of Diabetes Genetic Risk Counseling with Incident Diabetes and Weight: 5-Year Follow-up of a Randomized Controlled Trial

  • Sridharan RaghavanEmail author
  • Kerui Xu
  • Cynthia J. Coffman
  • Samantha Pabich
  • David Edelman
  • Corrine I. Voils
Concise Research Report


Despite advances in understanding the genetics of type 2 diabetes (T2D), the benefits of precision medicine—better disease risk prediction and individually tailored prevention or treatment—remain aspirational. While patients have reported that genetic risk information would motivate preventive health behavior change,1, 2 this has not been borne out in short-term studies of genetic risk counseling.3, 4 The adoption of risk-modifying behaviors may be delayed as patients accumulate T2D risk factors and learn behavior change skills. We report the 5-year follow-up results of a randomized genetic risk counseling intervention on incident T2D and weight in a population of adults with elevated diabetes risk.


The randomized clinical trial has been described.3 Briefly, 601 adults aged 21–65 years with body mass index (BMI) ≥ 27 kg/m2, not actively losing weight, and receiving primary care at the Durham Veterans Affairs (VA) Medical Center were randomized to receive...


Author Contributions

All authors contributed to study design and analysis plan development. Data were collected by CIV, CJC, DE, and KX; KX and CJC performed all analyses; all authors contributed to the interpretation of results, as well as drafting and critical revision of the manuscript.


SR is supported by the American Heart Association award 17MCPRP33670728 and US Department of Veterans Affairs (VA) award IK2-CX001907-01. CIV is supported by a Research Career Scientist award from the VA Health Services Research & Development service (RCS 14-443).

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they do not have a conflict of interest.


The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript. This work is not intended to reflect the official opinion of the US Department of Veterans Affairs, the National Institutes of Health, or the US government.

Supplementary material

11606_2019_5126_MOESM1_ESM.docx (36 kb)
ESM 1 (DOCX 35 kb)


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Copyright information

© Society of General Internal Medicine 2019

Authors and Affiliations

  1. 1.Department of Veterans Affairs Eastern Colorado Health Care SystemAuroraUSA
  2. 2.Division of Hospital MedicineUniversity of Colorado School of MedicineAuroraUSA
  3. 3.Colorado Cardiovascular Outcomes Research ConsortiumAuroraUSA
  4. 4.Department of SurgeryUniversity of Wisconsin School of Medicine and Public HealthMadisonUSA
  5. 5.Durham Center of Innovation to Accelerate Discovery and Practice TransformationDurhamUSA
  6. 6.Department of Biostatistics and BioinformaticsDuke University Medical CenterDurhamUSA
  7. 7.Division of Endocrinology, Diabetes and MetabolismUniversity of Wisconsin School of Medicine and Public HealthMadisonUSA
  8. 8.Division of General Internal MedicineDuke University School of MedicineDurhamUSA
  9. 9.William S. Middleton Memorial Veterans HospitalMadisonUSA

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