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Impact of Fixed-Dose Combination Drugs on Adherence to Prescription Medications

Journal of General Internal Medicine volume 23, pages 611–614 (2008)Cite this article

Abstract

Background

The inverse correlation between the complexity of a drug regimen and medication adherence is well established. Fixed-dose combination (FDC) therapies are hypothesized to enhance compliance by decreasing the number of required pills.

Objective

The objective of the study is to compare adherence of a FDC [Glucovance®, a FDC of metformin and glyburide] to a 2-pill regimen.

Design

Longitudinal data from a large claims database were used to assess adherence from January 1, 2000, to December 31, 2001. Propensity scoring methods were used to mitigate concerns related to non-random assignment of patients to treatments.

Subjects

The subjects of the study were individuals prescribed metformin or sulfonylurea or both before July 2000, who were prescribed both metformin and sulfonylurea concurrently (either separately or FDC) after August 2000.

Measurements

Adherence was measured by medication possession ratio; the proportion of days on which a patient had medication available.

Results

The FDC enhanced adherence rates by approximately 13% when compared to a 2-pill regimen.

Conclusions

Compared to 2-pill therapy, a FDC resulted in important increases in patient adherence. Economic analyses are warranted to determine whether the clinical benefits attributable to the adherence gains are worth the incremental cost of a FDC.

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Acknowledgment

The authors received neither internal nor external funding for the work represented in this manuscript.

Conflict of Interest Statement

None disclosed.

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Authors and Affiliations

  1. Department of Health Management and Policy, University of Michigan, Ann Arbor, MI, USA

    Feng Pan

  2. Department of Health Care Policy, Harvard Medical School, Boston, MA, USA

    Michael E. Chernew PhD

  3. Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA

    A. Mark Fendrick MD

  4. Department of Health Management and Policy, University of Michigan, Ann Arbor, MI, USA

    A. Mark Fendrick MD

Authors
  1. Feng Pan
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  2. Michael E. Chernew PhD
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  3. A. Mark Fendrick MD
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Correspondence to A. Mark Fendrick MD.

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Pan, F., Chernew, M.E. & Fendrick, A.M. Impact of Fixed-Dose Combination Drugs on Adherence to Prescription Medications. J GEN INTERN MED 23, 611–614 (2008). https://doi.org/10.1007/s11606-008-0544-x

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  • DOI: https://doi.org/10.1007/s11606-008-0544-x

Key words

  • adherence
  • fixed-dose combination drugs
  • prescription medications