Abstract
Background
The Caprini risk assessment model is a well-validated tool that identifies patients who would benefit from extended venous thromboembolism (VTE) prophylaxis beyond hospital discharge. VTE, particularly portal mesenteric vein thrombosis (PMVT), is a potentially devastating complication of laparoscopic sleeve gastrectomy (LSG); therefore, we sought to examine whether the model can be safely applied to LSG patients. We hypothesized that its use can minimize the incidence of postoperative VTE, including PMVT, without increasing the likelihood of bleeding complications.
Materials and Methods
We conducted a retrospective chart review of those patients who underwent LSG at our institution from 2010 and 2018, at which time the Caprini risk assessment model was already our institutional standard. We determined the patients’ Caprini scores at the time of discharge and whether patients at high risk of VTE were discharged from hospital on extended courses of VTE prophylaxis. We also recorded if bleeding complications or VTE events occurred in the first 180 days after LSG.
Results
Six hundred thirty-eight patients underwent LSG, including 521 (81.7%) women, with an average preoperative body mass index (BMI) of 44.4 kg/m2 (SD 6.8). One hundred fifty-eight (24.8%) patients had Caprini scores that warranted extended courses of VTE prophylaxis beyond hospital discharge. Three patients (0.47%) developed a postoperative VTE, but no patient developed PMVT. No bleeding complications were observed among patients who received extended VTE prophylaxis.
Conclusion
The Caprini risk assessment model can effectively identify patients after LSG who might benefit from extended courses of VTE prophylaxis. Extended VTE prophylaxis does not seem to confer increased bleeding risk in this patient population.
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References
Esteban Varela J, Nguyen NT. Laparoscopic sleeve gastrectomy leads the U.S. utilization of bariatric surgery at academic medical centers. Surg Obes Relat Dis. 2015 Oct;11(5):987–90.
Chung AY, Strassle PD, Schlottmann F, Patti MG, Duke MC, Farrell TM. Trends in Utilization and Relative Complication Rates of Bariatric Procedures. J Gastrointest Surg. 2019 Jul;23(7):1362–72.
Goitein D, Matter I, Raziel A, Keidar A, Hazzan D, Rimon U, et al. Portomesenteric Thrombosis Following Laparoscopic Bariatric Surgery: Incidence, Patterns of Clinical Presentation, and Etiology in a Bariatric Patient Population. JAMA Surg. 2013 Apr 1;148(4):340.
Longitudinal Assessment of Bariatric Surgery (LABS) Consortium, Flum DR, Belle SH, King WC, Wahed AS, Berk P, et al. Perioperative safety in the longitudinal assessment of bariatric surgery. N Engl J Med. 2009 Jul 30;361(5):445–54.
Iannelli A, Treacy P, Sebastianelli L, Schiavo L, Martini F. Perioperative complications of sleeve gastrectomy: Review of the literature. J Min Access Surg. 2019;15(1):1.
Salinas J, Barros D, Salgado N, Viscido G, Funke R, Pérez G, et al. Portomesenteric vein thrombosis after laparoscopic sleeve gastrectomy. Surg Endosc. 2014 Apr;28(4):1083–9.
Villagrán R, Smith G, Rodriguez W, Flores C, Cariaga M, Araya S, et al. Portomesenteric Vein Thrombosis After Laparoscopic Sleeve Gastrectomy: Incidence, Analysis and Follow-Up in 1236 Consecutive Cases. Obes Surg. 2016 Nov;26(11):2555–61.
Tan SBM, Greenslade J, Martin D, Talbot M, Loi K, Hopkins G. Portomesenteric vein thrombosis in sleeve gastrectomy: a 10-year review. Surgery for Obesity and Related Diseases. 2018 Mar;14(3):271–5.
Karaman K, Aziret M, Bal A, Öter V, Ercan M, Bostancı EB. Porto-mesenteric venous thrombosis after laparoscopic sleeve gastrectomy: A case report and systematic review of the 104 cases. Obesity Research & Clinical Practice. 2018 May;12(3):317–25.
Bartlett MA, Mauck KF, Daniels PR. Prevention of venous thromboembolism in patients undergoing bariatric surgery. Vasc Health Risk Manag. 2015;11:461–77.
Hamadi R, Marlow CF, Nassereddine S, Taher A, Finianos A. Bariatric venous thromboembolism prophylaxis: an update on the literature. Expert Rev Hematol. 2019 Sep;12(9):763–71.
Cassidy MR, Rosenkranz P, McAneny D. Reducing postoperative venous thromboembolism complications with a standardized risk-stratified prophylaxis protocol and mobilization program. J Am Coll Surg. 2014 Jun;218(6):1095–104.
Hachey KJ, Sterbling H, Choi DS, Pinjic E, Hewes PD, Munoz J, et al. Prevention of Postoperative Venous Thromboembolism in Thoracic Surgical Patients: Implementation and Evaluation of a Caprini Risk Assessment Protocol. J Am Coll Surg. 2016 Jun;222(6):1019–27.
Macht R, Gardner I, Talutis S, Rosenkranz P, Doherty G, McAneny D. Evaluation of a Standardized Risk-Based Venous Thromboembolism Prophylaxis Protocol in the Setting of Thyroid and Parathyroid Surgery. J Am Coll Surg. 2017 Jun;224(6):1029–35.
Caprini JA, Arcelus JI, Hasty JH, Tamhane AC, Fabrega F. Clinical assessment of venous thromboembolic risk in surgical patients. Semin Thromb Hemost. 1991;17 Suppl 3:304–12.
Cassidy MR, Macht RD, Rosenkranz P, Caprini JA, McAneny D. Patterns of Failure of a Standardized Perioperative Venous Thromboembolism Prophylaxis Protocol. Journal of the American College of Surgeons. 2016 Jun;222(6):1074–80.
ASMBS updated position statement on prophylactic measures to reduce the risk of venous thromboembolism in bariatric surgery patients. Surgery for Obesity and Related Diseases. 2013 Jul;9(4):493–7.
Aminian A, Andalib A, Khorgami Z, Cetin D, Burguera B, Bartholomew J, et al. Who Should Get Extended Thromboprophylaxis After Bariatric Surgery?: A Risk Assessment Tool to Guide Indications for Post-discharge Pharmacoprophylaxis. Annals of Surgery. 2017 Jan;265(1):143–50.
Gambhir S, Inaba CS, Alizadeh RF, Nahmias J, Hinojosa M, Smith BR, et al. Venous thromboembolism risk for the contemporary bariatric surgeon. Surg Endosc. 2020 Aug;34(8):3521–6.
Rosenberg JM, Tedesco M, Yao DC, Eisenberg D. Portal Vein Thrombosis Following Laparoscopic Sleeve Gastrectomy for Morbid Obesity. JSLS. 2012;16(4):639–43.
Shikora SA, Mahoney CB. Clinical Benefit of Gastric Staple Line Reinforcement (SLR) in Gastrointestinal Surgery: a Meta-analysis. OBES SURG. 2015 Jul;25(7):1133–41.
Janik MR, Walędziak M, Brągoszewski J, Kwiatkowski A, Paśnik K. Prediction Model for Hemorrhagic Complications after Laparoscopic Sleeve Gastrectomy: Development of SLEEVE BLEED Calculator. OBES SURG. 2017 Apr;27(4):968–72.
Pannucci CJ, Swistun L, MacDonald JK, Henke PK, Brooke BS. Individualized Venous Thromboembolism Risk Stratification Using the 2005 Caprini Score to Identify the Benefits and Harms of Chemoprophylaxis in Surgical Patients: A Meta-analysis. Annals of Surgery. 2017 Jun;265(6):1094–103.
Vaughn SC, Talutis SD, Cassidy MR, Sachs TE, Drake FT, Rosenkranz P, et al. Two novel risk factors for postoperative venous thromboembolism: A reconsideration of standard risk assessment and prophylaxis. Am J Surg. 2020 Nov;220(5):1338–43.
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Hasley, R.B., Aly, S., Carter, C.O. et al. Application of the Caprini Risk Assessment Model to Select Patients for Extended Thromboembolism Prophylaxis After Sleeve Gastrectomy. J Gastrointest Surg 26, 298–304 (2022). https://doi.org/10.1007/s11605-021-05214-8
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DOI: https://doi.org/10.1007/s11605-021-05214-8