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Construction of Esophagogastric Anastomosis in Rabbits with Magnetic Compression Technique

  • Original Article
  • Published:
Journal of Gastrointestinal Surgery

Abstract

Purpose

The magnetic compression technique (MCT) is a new surgical method that has been used for gastrointestinal anastomosis, choledochojejunostomy, and intestinal anastomosis, but there are no reports on its use for esophagogastric anastomosis. This study aimed to investigate the feasibility of using MCT to fashion esophagogastric anastomoses in rabbits.

Methods

Twenty rabbits were randomized into an MCT group (study group, n = 10) and a hand-sewn group (control group, n = 10). The magnetic compression anastomosis device used in this study was made of neodymium iron boron (NdFeB) and possessed parent (PMR) and daughter (DMR) magnetic rings. To fashion the anastomosis, the PMR and DMR were inserted into the lower esophagus and gastric fundus, respectively. The coupled magnets automatically compressed the sandwiched tissues and were expelled once the anastomosis was installed. The two groups were further compared in terms of the anastomosis construction time, survival rate, and postoperative complications. One month after the anastomosis was installed, the burst pressure and gross appearance of the anastomoses were evaluated.

Results

The anastomosis construction time in the study group was significantly shorter than that in the control group (10.50 ± 1.58 min vs. 18.60 ± 2.22 min; P < 0.05), and the magnetic rings were defecated out in 10.70 ± 3.49 days. The incidence of anastomotic blockage in both the study and control groups did not differ significantly (0%, 0/10 vs. 20%, 2/10; P > 0.05). Anastomotic leakage was not found in either of the groups, and the anastomoses burst pressures were similar in the two groups. However, the magnetically compressed anastomoses in the study group had a relatively smoother gross appearance than the hand-sewn anastomoses.

Conclusion

The magnetic compression anastomosis device is a safe and feasible tool for fashioning esophagogastric anastomoses in this animal model.

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Funding

This study was supported by the Innovation Capability Support Plan of Shaanxi Province, No. 2020KJXX-022; the Key Research & Development Program-Social Development of Shaanxi Province, No. 2021SF-163. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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Authors and Affiliations

  1. Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, China

    Dan Ye, Miao-Miao Zhang, Yi Lyu & Xiao-Peng Yan

  2. Department of Dermatology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China

    Dan Ye

  3. National and Local Joint Engineering Research Center of Precision Surgery and Regenerative Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, China

    Miao-Miao Zhang, Ai-Hua Shi, Yi Lyu & Xiao-Peng Yan

  4. Qide College, Xi’an Jiaotong University, Xi’an, China

    Wen-Wen Chen & Wei-Chen Shen

  5. Zonglian College, Xi’an Jiaotong University, Xi’an, China

    Hui-Min Gao & Jia-Hui Zhang

Authors
  1. Dan Ye
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  2. Miao-Miao Zhang
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  8. Yi Lyu
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  9. Xiao-Peng Yan
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Contributions

Conception and design: Yi Lyu, Xiao-Peng Yan.

Performed the research and acquired the data: Wen-Wen Chen, Hui-Min Gao, Xiao-Peng Yan, Dan Ye, Ai-Hua Shi, Wei-Chen Shen, Miao-Miao Zhang, Jia-Hui Zhang.

Analyzed the data: Dan Ye, Miao-Miao Zhang, Ai-Hua Shi.

Manuscript writing: Xiao-Peng Yan, Dan Ye, Miao-Miao Zhang.

Manuscript revision: Yi Lyu, Xiao-Peng Yan.

Final approval of manuscript: all authors.

Corresponding author

Correspondence to Xiao-Peng Yan.

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Ethics Approval

The Committee on the Ethics of Animal Experiments of Xi’an Jiaotong University (Permit Number: XJTULAC2019-999) approved the study protocol.

Conflict of Interest

The authors declare no competing interests.

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Cite this article

Ye, D., Zhang, MM., Shi, AH. et al. Construction of Esophagogastric Anastomosis in Rabbits with Magnetic Compression Technique. J Gastrointest Surg 25, 3033–3039 (2021). https://doi.org/10.1007/s11605-021-05178-9

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  • DOI: https://doi.org/10.1007/s11605-021-05178-9

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