Skip to main content
SpringerLink
Log in

Why Do Anastomoses Leak?

  • Evidence-Based Current Surgical Practice
  • Published:
Journal of Gastrointestinal Surgery

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Slieker J, Daams F, Mulder IM, Jeekel J, Lange JF. Systematic review of the technique of colorectal anastomosis. JAMA Surg 2013: 148(2):190-201.

  2. Gachabayov M, Bergamaschi R, Boni L, Uranues S, Fingerhut A. Splenic flexure mobilization in sigmoid and rectal resections: A systematic review and meta-analysis of observational studies. Surg Technol Int. 2019 May 15; 34:169-182.

  3. Neutzling CB, Lustosa SA, Proenca IM, da Silva EM, Matos D. Stapled versus handsewn methods for colorectal anastomosis surgery. Cochrane Database Syst Rev. 2012 Feb 15 ;( 2):CD003144. https://doi.org/10.1002/14651858.CD003144.pub2.

  4. Ricci C, Casadei R, Alagna V, Zani E, Taffurelli G, Pacilio CA, Minni F. A critical and comprehensive systematic review and meta-analysis of studies comparing intracorporeal and extracorporeal anastomosis in laparoscopic right hemicolectomy. Langenbecks Arch Surg. 2017 May; 402(3):417-427. https://doi.org/10.1007/s00423-016-1509-x.

  5. Murray AC, Chiuzan C, Kiran RP. Risk of anastomotic leak after laparoscopic versus open colectomy. Surg Endosc. 2016 Dec; 30(12):5275-5282. https://doi.org/10.1007/s00464-016-4875-0.

  6. Pucciarelli S, Del Bianco P, Pace U, Bianco F, Restivo A, Maretto I, Selvaggi F, Zorcolo Z, De Franciscis S, Asteria C, Urso EDL, Cuicchi D, Pellino G, Morpurgo E, La Torre G, Jovine E, Belluco C, La Torre F, Amato A, Chiappa A, Infantino A, Barina A, Spolverato G, Rega D, Kilmartin D, De Salvo GL, Delrio P. Multicentre randomized clinical trial of colonic J pouch or straight stapled colorectal reconstruction after low anterior resection for rectal cancer. Br J Surg. 2019 Aug; 106(9):1147–1155. https://doi.org/10.1002/bjs.11222.

  7. Hyman N, Osler T, Cataldo P, Burns B, Shackford S. Anastomotic leaks after bowel resection: What does peer review teach us about the relationship to postoperative mortality? J Am Coll Surg, 2009; 208(1):48-52.

  8. Jafari MD, Wexner SD, Martz JE, et al. Perfusion assessment in laparoscopic left-sided/anterior resection (PILLAR II): a multi-institutional study. Journal of the American College of Surgeons 2015; 220:82-92 e1. https://doi.org/10.1016/j.jamcollsurg.2014.09.015.

  9. Jafari MD, Pigazzi A, McLemore EC, et al. Perfusion assessment in left-sided/low anterior resection (PILLAR III): A randomized, controlled, parallel, multicenter study assessing perfusion outcomes with PINPOINT near-infrared fluorescence imaging in low anterior resection. Diseases of the Colon and Rectum 2021 Apr 13. https://doi.org/10.1097/DCR.0000000000002007.

  10. De Nardi P, Elmore U, Maggi G, et al. Intraoperative angiography with indocyanine green to assess anastomosis perfusion in patients undergoing laparoscopic colorectal resection: results of a multicenter randomized controlled trial. Surgical Endoscopy 2020; 34:53-60. https://doi.org/10.1007/s00464-019-06730-0.

  11. Alekseev M, Rybakov E, Shelygin Y, Chernyshov S, Zarodnyuk I. A study investigating the perfusion of colorectal anastomoses using fluorescence angiography: results of the FLAG randomized trial. Colorectal disease 2020 Sep; 22(9):1147-1153. https://doi.org/10.1111/codi.15037.

  12. Armstrong G, Croft J, Corrigan N, et al. IntAct: intra-operative fluorescence angiography to prevent anastomotic leak in rectal cancer surgery: a randomized controlled trial. Colorectal disease: the official journal of the Association of Coloproctology of Great Britain and Ireland 2018; 20:O226-O34. https://doi.org/10.1111/codi.14257.

  13. Cohn I, Rives JD. Protection of colonic anastomoses with antibiotics. Ann Surg. 1956; 144(4):738–752. http://www.ncbi.nlm.nih.gov/pubmed/13373258.

  14. Jacobson RA, Wienholts K, Williamson AJ, et al. Enterococcus faecalis exploits the human fibrinolytic system to drive excess collagenolysis: implications in gut healing and identification of druggable targets. Am J Physiol Gastrointest Liver Physiol. 2020;318(1):G1-G9. https://doi.org/10.1152/ajpgi.00236.2019.

  15. Jacobson RA, Wienholts K, Williamson AJ, et al. Enterococcus faecalis exploits the human fibrinolytic system to drive excess collagenolysis: implications in gut healing and identification of druggable targets. Am J Physiol Gastrointest Liver Physiol. 2020;318(1):G1-G9. https://doi.org/10.1152/ajpgi.00236.2019.

  16. Guyton K, Belogortseva N, Levine Z, et al. Patient acceptance of routine serial postoperative endoscopy following low anterior resection (LAR) and its ability to Detect Biomarkers in Anastomotic Lavage Fluid. World J Surg. March 2021. https://doi.org/10.1007/s00268-021-06062-y2020; 318(1):G1-G9. https://doi.org/10.1152/ajpgi.00236.2019.

  17. van Praagh JB, de Goffau MC, Bakker IS, et al. Mucus microbiome of anastomotic tissue during surgery has predictive value for colorectal anastomotic leakage. Ann Surg. January 2018. https://doi.org/10.1097/SLA.0000000000002651.

Download references

Author information

Authors and Affiliations

  1. Department of Surgery, University of California, Irvine, CA, USA

    Mehraneh D. Jaferi

  2. Department of Surgery, University of Arizona, Tucson, AZ, USA

    Valentine Nfonsam

  3. Department of Surgery, University of Chicago Medicine, Chicago, IL, USA

    Benjamin Shogan & Neil Hyman

Authors
  1. Mehraneh D. Jaferi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Valentine Nfonsam
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Benjamin Shogan
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Neil Hyman
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Neil Hyman.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

SSAT Clinical Ward Rounds, Presented at Digestive Diseases Week (virtual), May 22, 2021.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Jaferi, M.D., Nfonsam, V., Shogan, B. et al. Why Do Anastomoses Leak?. J Gastrointest Surg 25, 2728–2731 (2021). https://doi.org/10.1007/s11605-021-05103-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11605-021-05103-0

Keywords

Search

Navigation