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Clinical Outcomes of Endoscopic Treatment for Type 1 Gastric Neuroendocrine Tumor

  • Original Article
  • Published:
Journal of Gastrointestinal Surgery

Abstract

Background

Although the rate of early detection and endoscopic treatment of gastric neuroendocrine tumors (NETs) is steadily increasing, there are insufficient studies on the long-term outcomes of endoscopic treatment. Therefore, we aimed to investigate the clinical features and long-term outcomes of endoscopic treatment for type 1 gastric NETs.

Methods

Subjects who underwent endoscopic treatment for gastric NETs between March 1997 and December 2015 were included. Clinical features and endoscopic treatment outcomes were retrospectively investigated by reviewing medical records.

Results

In total, 125 subjects underwent endoscopic treatment including forceps biopsy (n = 21), argon plasma coagulation (n = 1), endoscopic mucosal resection (EMR, n = 62), and endoscopic submucosal dissection (ESD, n = 41). In total, 103 patients with 114 lesions, who underwent EMR or ESD, were analyzed to evaluate endoscopic and oncologic outcomes. The rates of en bloc resection in the EMR and ESD groups were 91.5% and 97.7%, respectively. Complete resection rates were significantly higher in the ESD group than in the EMR group; it was also higher in < 1-cm small-sized lesions than in 1–2-cm large-sized lesions. Adverse events were similar between the two groups. During a median follow-up period of 63 months, local recurrence rates were 6.5% and 2.4% in the EMR and ESD groups, respectively, and the disease-free survival rate did not differ significantly between the groups.

Conclusion

Endoscopic treatment for type 1 gastric NETs less than 2 cm in diameter and confined to mucosal and submucosal layers could be an effective and safe treatment strategy based on the favorable long-term outcome.

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Authors and Affiliations

  1. Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

    Jin Hee Noh, Do Hoon Kim, Hwan Yoon, Li-Chang Hsing, Hee Kyong Na, Ji Yong Ahn, Jeong Hoon Lee, Kee Wook Jung, Kee Don Choi, Ho June Song, Gin Hyug Lee & Hwoon-Yong Jung

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Correspondence to Do Hoon Kim.

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Supplementary Information

Supplementary Figure 1

Kaplan–Meier survival curves for disease-free survival according to endoscopic treatment (log rank p value = 0.053) (n = 124) (JPG 27 kb)

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Noh, J.H., Kim, D.H., Yoon, H. et al. Clinical Outcomes of Endoscopic Treatment for Type 1 Gastric Neuroendocrine Tumor. J Gastrointest Surg 25, 2495–2502 (2021). https://doi.org/10.1007/s11605-021-04997-0

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  • DOI: https://doi.org/10.1007/s11605-021-04997-0

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