Skip to main content

The Role of Ki-67 Index Cut-off of 55% and Differentiation in Redefining NET and NEC for Grade 3 Gastrointestinal Neuroendocrine Neoplasms

Journal of Gastrointestinal Surgery volume 24, pages 2302–2305 (2020)Cite this article

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

43,34 €

Price includes VAT (Finland)
Tax calculation will be finalised during checkout.

Fig. 1

References

  1. Lloyd RV OR, Klöppel G, Rosai J.: WHO classification of tumours of endocrine organs. Lyon: IARC Press; 2017.

    Google Scholar 

  2. Nagtegaal ID, Odze RD, Klimstra D, Paradis V, Rugge M, Schirmacher P, Washington KM, Carneiro F, Cree IA, Board WHOCoTE: The 2019 WHO classification of tumours of the digestive system. Histopathology 2020, 76(2):182–188.

    Article  Google Scholar 

  3. Brims FJ, Meniawy TM, Duffus I, de Fonseka D, Segal A, Creaney J, Maskell N, Lake RA, de Klerk N, Nowak AK: A Novel Clinical Prediction Model for Prognosis in Malignant Pleural Mesothelioma Using Decision Tree Analysis. Journal of thoracic oncology: official publication of the International Association for the Study of Lung Cancer 2016, 11(4):573–582.

    Article  Google Scholar 

  4. Lu Y, Liu L, Luan S, Xiong J, Geng D, Yin B: The diagnostic value of texture analysis in predicting WHO grades of meningiomas based on ADC maps: an attempt using decision tree and decision forest. Eur Radiol 2019, 29(3):1318–1328.

    Article  Google Scholar 

Download references

Funding

Supported by the National Natural Science Foundation of China (Nos. 81770539 and 81572428), the National key research and development program of China (No. 2017YFC0110003), and the Guangzhou Science and Technology Plan (201804010078). The funding body had no part in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.

Author information

Author notes

  1. Huiying Shi, Luohai Chen and Lingjun Meng contributed equally to this work.

Affiliations

  1. Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

    Huiying Shi, Lingjun Meng & Rong Lin

  2. Department of Gastroenterology, the First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan II Road, Guangzhou, China

    Luohai Chen & Jie Chen

  3. Department of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

    Qin Zhang

  4. Department of Pathology, the First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan II Road, Guangzhou, China

    Yuan Lin

Authors
  1. Huiying Shi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Luohai Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Lingjun Meng
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Qin Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yuan Lin
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Rong Lin
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Jie Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

Huiying Shi, Luohai Chen, and Lingjun Meng contributed equally to this work. R.L. and J.C designed and supervised the study and data analysis; H.S., L.C., and L.M. performed most of data collection, analysis, and wrote the manuscript; Q.Z and Y.L. provided pathological assessment and analysis.

Corresponding authors

Correspondence to Rong Lin or Jie Chen.

Ethics declarations

Conflict of Interest

The authors declare that they have no conflict of interest.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Shi, H., Chen, L., Meng, L. et al. The Role of Ki-67 Index Cut-off of 55% and Differentiation in Redefining NET and NEC for Grade 3 Gastrointestinal Neuroendocrine Neoplasms. J Gastrointest Surg 24, 2302–2305 (2020). https://doi.org/10.1007/s11605-020-04651-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11605-020-04651-1

Keywords

  • Gastroenteropancreatic neuroendocrine neoplasms
  • Classification
  • Ki-67 index
  • Grade 3 gastric neuroendocrine tumors (G3 g-NETs)
  • Prognostic factors