Abstract
Background
Recent literature has shown disparities in diagnosis and treatment of anal cancer. Common perception is that many anal cancer patients may experience a delay in diagnosis and this may contribute to poor outcomes.
Methods
Patients diagnosed with anal cancer at a single academic institution from 2006 to 2017 were retrospectively reviewed. Patients were stratified according to time from symptom onset to diagnosis and divided into three groups: diagnosed within 6 weeks, between 6 weeks and 6 months, and greater than 6 months.
Results
A total of 93 patients were included in this study. Twenty-two (23.7%) were diagnosed within 6 weeks, 48 (51.6%) between 6 weeks and 6 months, and 23 (24.7%) were diagnosed more than 6 months after the onset of symptoms. Over half (57%) of all patients were initially diagnosed with a benign condition. Stage did not vary significantly between groups. Patient diagnosed within 6 weeks had the highest rates of completion of chemotherapy (90%), radiation (95%), and complete response to chemoradiation (77%) but these did not reach statistical significance. There was no difference in recurrence, or overall survival between the groups.
Conclusions
Over half of anal cancer patients were initially misdiagnosed, and 25% were symptomatic for more than 6 months prior to diagnosis. Those patients diagnosed earlier tended to be more likely to receive complete chemoradiation therapy. We were unable to show a statistical difference in outcomes between groups. Further investigation into provider education and awareness of anal cancer is warranted to improve the care of these patients.
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References
Nelson VM, Benson AB. Epidemiology of Anal Canal Cancer. Surg Oncol Clin N Am. 2017;26(1):9–15. https://doi.org/10.1016/j.soc.2016.07.001
Noone A, Howlader N, Krapcho N, et al. SEER Cancer Statistics Review, 1975–2015, National Cancer Institute. Bethesda, MD; 2018.
Wheldon C, Krakow M, Thompson E, Moser R. National Trends in Human Papillomavirus Awareness and Knowledge of Human Papillomavirus-Related Cancers. Am J Prev Med. 2019;56(4):e117-e123.
Chiu S, Joseph K, Ghosh S, Cornand RM, Schiller D. Reasons for delays in diagnosis of anal cancer and the effect on patient satisfaction. Can Fam Physician. 2015;61(11):e509–16.
Edwards AT, Morus LC, Foster ME, Griffith GH. Anal Cancer: The Case for Earlier Diagnosis. J R Soc Med. 1991;84(7):395–397. https://doi.org/10.1177/014107689108400705
Celie KB, Jackson C, Agrawal S, et al. Socioeconomic and gender disparities in anal cancer diagnosis and treatment. Surg Oncol. 2017;26(2):212–217. https://doi.org/10.1016/j.suronc.2017.03.008
Ramey SJ, Rich BJ, Kwon D, et al. Demographic disparities in delay of definitive chemoradiation for anal squamous cell carcinoma: a nationwide analysis. J Gastrointest Oncol. 2018;9(6):1109–1126. https://doi.org/10.21037/jgo.2018.08.07
Shridhar R, Shibata D, Chan E, Thomas CR. Anal cancer: Current standards in care and recent changes in practice. CA Cancer J Clin. 2015;65(2):139–162. https://doi.org/10.3322/caac.21259
Glynne-Jones R, Nilsson PJ, Aschele C, et al. Anal cancer: ESMO-ESSO-ESTRO clinical practice guidelines for diagnosis, treatment and follow-up. Eur J Surg Oncol. 2014. https://doi.org/10.1016/j.ejso.2014.07.030
Grucela A, Salinas H, Khaitov S, Steinhagen RM, Gorfine SR, Chessin DB. Prospective analysis of clinician accuracy in the diagnosis of benign anal pathology: Comparison across specialties and years of experience. Dis Colon rectum. 2010. https://doi.org/10.1007/DCR.0b013e3181bbfc89
Patel HS, Silver ARJ, Northover JMA. Anal cancer in renal transplant patients. Int J Colorectal Dis. 2007;22(1):1–5. https://doi.org/10.1007/s00384-005-0023-3
Clarke MA, Wentzensen N. Strategies for Screening and Early Detection of Anal Cancers: A Narrative and Systematic Review and Meta-Analysis of Cytology, HPV Testing, and Other Biomarkers. Cancer Cytopathol. 2018;126(7):447–460. https://doi.org/10.1002/cncy.22018
Leeds IL. Anal cancer and intraepithelial neoplasia screening: A review. World J Gastrointest Surg. 2016. https://doi.org/10.4240/wjgs.v8.i1.41
Hicks J, Hwang L, Baraniuk S, et al. Factors associated with self-reported anal cancer screening history in men who have sex with men. Sex Heal. 2019;16(1):96–98.
Acknowledgments
We would like to acknowledge the support of the Department of Surgery at University Hospitals Cleveland Medical Center and the University Hospitals Research in Surgical Outcomes & Effectiveness Center (UH-RISES).
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KB, AO, SLS, and ES contributed to project design and drafting and revising the manuscript. Data collection and analysis was performed by KB. All authors have approved the final paper.
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Dr. Sharon L. Stein is a consultant for Merck Sharp and Medtronics.
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This manuscript was presented at Digestive Diseases Week May 2019, San Diego CA.
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Bingmer, K., Ofshteyn, A., Stein, S.L. et al. Delayed Diagnosis of Anal Cancer. J Gastrointest Surg 24, 212–217 (2020). https://doi.org/10.1007/s11605-019-04364-0
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DOI: https://doi.org/10.1007/s11605-019-04364-0