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The Feasibility and Safety of Preoperative Fluorescence Marking with Indocyanine Green (ICG) in Laparoscopic Gastrectomy for Gastric Cancer

Journal of Gastrointestinal Surgery volume 23, pages 468–476 (2019)Cite this article

Abstract

Background

Securing the surgical margin is the most essential and important task in curative surgery. However, it is difficult to accurately identify the tumor location during laparoscopic surgery for gastric cancer, and existing methods, such as preoperative endoscopic marking with tattooing and clipping, have multiple disadvantages.

Aims

We investigated the feasibility and safety of indocyanine green (ICG) fluorescence marking for determining the tumor location during laparoscopic gastrectomy.

Methods

We retrospectively analyzed preoperative and perioperative data from consecutive patients with gastric cancer undergoing planned laparoscopic distal gastrectomy. Data was maintained in a prospectively compiled surgical database, and patients were categorized into ICG (n = 84) or non-ICG (n = 174) groups based on whether they underwent preoperative endoscopic mucosal ICG injection. One-to-one propensity score matching (PSM) was performed to compare outcomes between the two groups.

Results

We included 84 patient pairs after PSM, and there were no significant differences in preoperative patient characteristics. The ICG group had shorter procedure time (p < 0.001), lower estimated blood loss (p = 0.005), and significantly shorter postoperative hospital stay (p < 0.001). Positive resection margins were confirmed in five cases (6.0%) in the non-ICG group, whereas there were none in the ICG group (p = 0.008). Real-time confirmation was possible during laparoscopy, and the injected ICG did not affect the surgical procedure or result in adverse events.

Conclusion

ICG fluorescence imaging is feasible and safe and can potentially be used as a tumor-marking agent for determining the surgical resection line.

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Author information

Affiliations

  1. Department of Gastroenterological Surgery, Osaka International Cancer Institute, 3-1-69 Ohtemae, Chuo-ku, Osaka, 541-8567, Japan

    Yuki Ushimaru, Takeshi Omori, Yoshiyuki Fujiwara, Yoshitomo Yanagimoto, Keijiro Sugimura, Kazuyoshi Yamamoto, Jeong-Ho Moon, Hiroshi Miyata, Masayuki Ohue & Masahiko Yano

Authors
  1. Yuki Ushimaru
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  2. Takeshi Omori
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  3. Yoshiyuki Fujiwara
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  4. Yoshitomo Yanagimoto
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  5. Keijiro Sugimura
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  6. Kazuyoshi Yamamoto
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  7. Jeong-Ho Moon
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  8. Hiroshi Miyata
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  10. Masahiko Yano
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Contributions

Ushimaru designed the study and wrote the initial draft of the manuscript. Omori contributed to the interpretation of the data and to the critical revision of the manuscript for important intellectual content. All the other authors (Fujiwara, Yanagimoto, Sugimura, Yamamoto, Moon, Miyata, Ohue, and Yano) contributed to data collection and interpretation and critical review of the manuscript. All the authors have read and approved the final version of the manuscript and have agreed to the accountability of all aspects of the study, ensuring that any queries related to the accuracy or integrity of any part of the work are answerable.

Corresponding author

Correspondence to Takeshi Omori.

Ethics declarations

This study was approved by the Institutional Review Board of the Osaka International Cancer Institute. All patients signed a written informed consent. Data collection and analysis were performed in compliance with the Helsinki Declaration of 1975.

Disclosures

Drs. Yuki Ushimaru, Takeshi Omori, Yoshiyuki Fujiwara, Yoshitomo Yanagimoto, Keijiro Sugimura, Kazuyoshi Yamamoto, Jeong-Ho Moon, Hiroshi Miyata, Masayuki Ohue, and Masahiko Yano have no conflicts of interest or financial ties to declare.

Conflict of Interest

There are no funding sources for this study or any associated financial conflicts.

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Ushimaru, Y., Omori, T., Fujiwara, Y. et al. The Feasibility and Safety of Preoperative Fluorescence Marking with Indocyanine Green (ICG) in Laparoscopic Gastrectomy for Gastric Cancer. J Gastrointest Surg 23, 468–476 (2019). https://doi.org/10.1007/s11605-018-3900-0

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  • DOI: https://doi.org/10.1007/s11605-018-3900-0

Keywords

  • Gastric cancer
  • Curative resection
  • Indocyanine green fluorescence imaging
  • Tumor localization
  • Total laparoscopic gastrectomy