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Genetic Factors Associated with Postoperative Nausea and Vomiting: a Systematic Review

Journal of Gastrointestinal Surgery volume 22, pages 1645–1651 (2018)Cite this article

Abstract

Background

In previous studies, there seems to be a relationship between different genetic polymorphisms and postoperative nausea and vomiting (PONV). We perform a systematic review of the current literature about the relationship between genetic polymorphisms and the presence of PONV.

Methods

Two bibliographic searches were carried out in three databases (PubMed, Web of Science, and Scopus) of studies, preferably prospective, about PONV following abdominal surgery. It was completed with a backward citation searching. A total of 73 articles were found of which 6 were selected after their critical lecture using CASPe network criteria. Relative frequency and relative risk were taken in each study according to the polymorphism.

Results

Studies about 5-HT3B gene receptor polymorphisms, ABCB1 transporter, and dopamine D2 receptor showed a significant association with the presence of PONV (p = 0.02, 0.01, and 0.034 respectively). In relation to cytochrome P-450 2D6 (CYP2D6) polymorphisms, two of the three analysed articles showed a significant association with postoperative vomiting (p = 0.007).

Conclusion

Genetic polymorphisms could play an important role in PONV. The AAG deletion in both alleles of the 5-HT3B receptor gene, the Taq IA polymorphism of the dopamine D2 receptor, and the presence of three or more functional alleles of CYP2D6 seem to be related with a higher incidence of PONV, especially in the first 24 h after surgery. The 2677TT and 3435TT genotypes of the ABCB1 transporter could reduce the PONV due to their association with a greater effectiveness of ondansetron. However, new quality studies are needed to consider this relationship.

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Authors and Affiliations

  1. Faculty of Medicine, IMIB-Arrixaca, “Mare Nostrum” International Excellence Campus, University of Murcia, Murcia, Spain

    Pedro López-Morales, Diego Flores-Funes, Elena González Sánchez-Migallón, Ramón José Lirón-Ruiz & José Luis Aguayo-Albasini

  2. Department of Surgery, Morales Meseguer General University Hospital, Murcia, Spain

    Pedro López-Morales, Diego Flores-Funes, Elena González Sánchez-Migallón, Ramón José Lirón-Ruiz & José Luis Aguayo-Albasini

  3. Department of General and Digestive Surgery, Morales Meseguer General University Hospital, Murcia, Spain

    Diego Flores-Funes, Elena González Sánchez-Migallón & Ramón José Lirón-Ruiz

  4. Servicio de Cirugía General y del Aparato Digestivo, Hospital General Universitario Morales Meseguer, Avenida Marqués de los Vélez, S/N, 30008, Murcia, Spain

    Diego Flores-Funes

  5. General and Digestive Department, Morales Meseguer General University Hospital, Murcia, Spain

    José Luis Aguayo-Albasini

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  1. Pedro López-Morales
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Correspondence to Diego Flores-Funes.

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López-Morales, P., Flores-Funes, D., Sánchez-Migallón, E.G. et al. Genetic Factors Associated with Postoperative Nausea and Vomiting: a Systematic Review. J Gastrointest Surg 22, 1645–1651 (2018). https://doi.org/10.1007/s11605-018-3788-8

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  • DOI: https://doi.org/10.1007/s11605-018-3788-8

Keywords

  • Postoperative nausea and vomiting
  • Genetic polymorphism
  • Risk factor
  • Ondansetron
  • Ultrarapid metaboliser