Comparison of Hepatectomy for Patients with Metabolic Syndrome-Related HCC and HBV-Related HCC
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Metabolic syndrome (MetS) is a group of clinicopathological manifestations. The outcome of liver surgery in metabolic syndrome-related hepatocellular carcinoma (MetS-HCC) still needs to be evaluated. We aim to clarify the outcomes following liver resection in patients with MetS-HCC compared those with hepatitis B virus-related HCC (HBV-HCC).
All the consecutive patients undergoing hepatectomy for HCC between January 2009 and December 2012 were retrospectively considered. Patients were divided into three groups: MetS-HCC, MetS-HBV-HCC, and HBV-HCC. Data on clinical characteristics, postoperative complications, and long-term outcome were collected and analyzed.
A total of 1352 patients were included in this study. In MetS-HCC group, the severe morbidity rate was 33.33%, which was higher than that of HBV-HCC group (15.68%). In subgroup analysis, patients with MetS-HCC in American Joint Committee on Cancer (AJCC) stage I had superior DFS and OS when compared with those of the other two groups.
We should pay more attention to patients with MetS-HCC perioperatively due to the high rate of surgical complications. Nevertheless, curative treatment should be provided to patients with MetS.
KeywordsHepatectomy Metabolic syndrome Hepatitis virus B Hepatocellular carcinoma Surgery
Feng Shen and Yunhong Tian designed the research; Feng Shen, Jun Li, and Yong Xia performed the surgery and collected the data; Yunhong Tian, Jun Li, and Huan Lyu contributed to the discussion part. Huan Lyu and Yunhong He analyzed the data; Yunhong Tian wrote the paper.
All authors are in agreement with the contents of the manuscript and confirm that the paper is not being published or under consideration elsewhere.
This work was supported by the foundation of Sichuan Medical Association [S16045] and Health and Family Planning Commission of Sichuan Province [16PJ206].
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