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Journal of Gastrointestinal Surgery

, Volume 22, Issue 4, pp 615–623 | Cite as

Comparison of Hepatectomy for Patients with Metabolic Syndrome-Related HCC and HBV-Related HCC

  • Yunhong Tian
  • Huan Lyu
  • Yunhong He
  • Yong Xia
  • Jun Li
  • Feng Shen
Original Article
  • 296 Downloads

Abstract

Background

Metabolic syndrome (MetS) is a group of clinicopathological manifestations. The outcome of liver surgery in metabolic syndrome-related hepatocellular carcinoma (MetS-HCC) still needs to be evaluated. We aim to clarify the outcomes following liver resection in patients with MetS-HCC compared those with hepatitis B virus-related HCC (HBV-HCC).

Methods

All the consecutive patients undergoing hepatectomy for HCC between January 2009 and December 2012 were retrospectively considered. Patients were divided into three groups: MetS-HCC, MetS-HBV-HCC, and HBV-HCC. Data on clinical characteristics, postoperative complications, and long-term outcome were collected and analyzed.

Results

A total of 1352 patients were included in this study. In MetS-HCC group, the severe morbidity rate was 33.33%, which was higher than that of HBV-HCC group (15.68%). In subgroup analysis, patients with MetS-HCC in American Joint Committee on Cancer (AJCC) stage I had superior DFS and OS when compared with those of the other two groups.

Conclusions

We should pay more attention to patients with MetS-HCC perioperatively due to the high rate of surgical complications. Nevertheless, curative treatment should be provided to patients with MetS.

Keywords

Hepatectomy Metabolic syndrome Hepatitis virus B Hepatocellular carcinoma Surgery 

Notes

Author Contribution

Feng Shen and Yunhong Tian designed the research; Feng Shen, Jun Li, and Yong Xia performed the surgery and collected the data; Yunhong Tian, Jun Li, and Huan Lyu contributed to the discussion part. Huan Lyu and Yunhong He analyzed the data; Yunhong Tian wrote the paper.

All authors are in agreement with the contents of the manuscript and confirm that the paper is not being published or under consideration elsewhere.

Funding

This work was supported by the foundation of Sichuan Medical Association [S16045] and Health and Family Planning Commission of Sichuan Province [16PJ206].

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Copyright information

© The Society for Surgery of the Alimentary Tract 2017

Authors and Affiliations

  • Yunhong Tian
    • 1
    • 2
    • 3
  • Huan Lyu
    • 3
  • Yunhong He
    • 3
  • Yong Xia
    • 1
  • Jun Li
    • 1
  • Feng Shen
    • 1
  1. 1.Department of Hepatic Surgery, Eastern Hepatobiliary Surgery HospitalThe Second Military Medical UniversityShanghaiChina
  2. 2.Graduate School of Soochow UniversitySuzhouChina
  3. 3.Department of General SurgeryNanchong Central HospitalNanchongChina

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