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Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy in Colorectal Cancer: Potential use of Perioperative Desmopressin to Reduce Allogenic Blood Transfusion Rates

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Journal of Gastrointestinal Surgery

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References

  1. Qiu L, Wang DR, Zhang XY, Gao S, Li XX, Sun GP and Lu XB. Impact of perioperative blood transfusion on immune function and prognosis in colorectal cancer patients. Transfus Apher Sci 2016; 54:235–241.

    Article  PubMed  Google Scholar 

  2. Li L, Zhu D, Chen X, Huang Y, Ouyang M and Zhang W. Perioperative Allogenenic Blood Transfusion is Associated With Worse Clinical Outcome for Patients Undergoing Gastric Carcinoma Surgery: A Meta-Analysis. Medicine (Baltimore) 2015; 94:e1574.

    Article  Google Scholar 

  3. Bennett S, Baker LK, Martel G, Shorr R, Pawlik TM, Tinmouth A, McIsaac DI, Hebert PC, Karanicolas PJ, McIntyre L, Turgeon AF, Barkun J and Fergusson D. The impact of perioperative red blood cell transfusions in patients undergoing liver resection: a systematic review. HPB (Oxford) 2017; 19:321–330.

    Article  Google Scholar 

  4. Sutton JM, Kooby DA, Wilson GC, Squires MH, 3rd, Hanseman DJ, Maithel SK, Bentrem DJ, Weber SM, Cho CS, Winslow ER, Scoggins CR, Martin RC, 2nd, Kim HJ, Baker JJ, Merchant NB, Parikh AA, Abbott DE, Edwards MJ and Ahmad SA. Perioperative blood transfusion is associated with decreased survival in patients undergoing pancreaticoduodenectomy for pancreatic adenocarcinoma: a multi-institutional study. J Gastrointest Surg 2014; 18:1575–1587.

    Article  PubMed  Google Scholar 

  5. Saxena A, Valle SJ, Liauw W and Morris DL. Allogenic Blood Transfusion Is an Independent Predictor of Poorer Peri-operative Outcomes and Reduced Long-Term Survival after Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: a Review of 936 Cases. J Gastrointest Surg 2017; 21:1318–1327.

    Article  PubMed  Google Scholar 

  6. Alonso DF, Ripoll GV, Garona J, Iannucci NB and Gomez DE. Metastasis: recent discoveries and novel perioperative treatment strategies with particular interest in the hemostatic compound desmopressin. Curr Pharm Biotechnol 2011; 12:1974–1980.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Ripoll GV, Garona J, Hermo GA, Gomez DE and Alonso DF. Effects of the synthetic vasopressin analog desmopressin in a mouse model of colon cancer. Anticancer Res 2010; 30:5049–5054.

    CAS  PubMed  Google Scholar 

  8. Turner NA and Moake JL. Factor VIII Is Synthesized in Human Endothelial Cells, Packaged in Weibel-Palade Bodies and Secreted Bound to ULVWF Strings. PLoS One 2015; 10:e0140740.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Starke RD, Ferraro F, Paschalaki KE, Dryden NH, McKinnon TA, Sutton RE, Payne EM, Haskard DO, Hughes AD, Cutler DF, Laffan MA and Randi AM. Endothelial von Willebrand factor regulates angiogenesis. Blood 2011; 117:1071–1080.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Mochizuki S, Soejima K, Shimoda M, Abe H, Sasaki A, Okano HJ, Okano H and Okada Y. Effect of ADAM28 on carcinoma cell metastasis by cleavage of von Willebrand factor. J Natl Cancer Inst 2012; 104:906–922.

    Article  CAS  PubMed  Google Scholar 

  11. Gragnano F, Sperlongano S, Golia E, Natale F, Bianchi R, Crisci M, Fimiani F, Pariggiano I, Diana V, Carbone A, Cesaro A, Concilio C, Limongelli G, Russo M and Calabro P. The Role of von Willebrand Factor in Vascular Inflammation: From Pathogenesis to Targeted Therapy. Mediators Inflamm 2017; 5620314.

  12. Giron S, Tejera AM, Ripoll GV, Gomez DE and Alonso DF. Desmopressin inhibits lung and lymph node metastasis in a mouse mammary carcinoma model of surgical manipulation. J Surg Oncol 2002; 81:38–44.

    Article  PubMed  Google Scholar 

  13. Ripoll GV, Garona J, Pifano M, Farina HG, Gomez DE and Alonso DF. Reduction of tumor angiogenesis induced by desmopressin in a breast cancer model. Breast Cancer Res Treat 2013; 142:9–18.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Weinberg RS, Grecco MO, Ferro GS, Seigelshifer DJ, Perroni NV, Terrier FJ, Sanchez-Luceros A, Maronna E, Sanchez-Marull R, Frahm I, Guthmann MD, Di Leo D, Spitzer E, Ciccia GN, Garona J, Pifano M, Torbidoni AV, Gomez DE, Ripoll GV, Gomez RE, Demarco IA and Alonso DF. A phase II dose-escalation trial of perioperative desmopressin (1-desamino-8-d-arginine vasopressin) in breast cancer patients. Springerplus 2015; 4:428.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Saxena A, Chua TC, Fransi S, Liauw W and Morris DL. Effectiveness of early and aggressive administration of fresh frozen plasma to reduce massive blood transfusion during cytoreductive surgery. J Gastrointest Oncol 2013; 4:30–39.

    PubMed  PubMed Central  Google Scholar 

  16. Sargant N, Roy A, Simpson S, Chandrakumaran K, Alves S, Coakes J, Bell J, Knight J, Wilson P, Mohamed F, Cecil T and Moran B. A protocol for management of blood loss in surgical treatment of peritoneal malignancy by cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Transfus Med 2016; 26:118–122.

    Article  CAS  PubMed  Google Scholar 

  17. Garona J, Pifano M, Scursoni AM, Gomez DE, Alonso DF and Ripoll GV. Insight into the effect of the vasopressin analog desmopressin on lung colonization by mammary carcinoma cells in BALB/c mice. Anticancer Res 2014; 34:4761–4765.

    PubMed  Google Scholar 

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Acknowledgements

D.F. Alonso and J. Garona serve as consultants/advisors to Elea and Chemo-Romikin.

Author information

Authors and Affiliations

  1. Laboratory of Molecular Oncology, National University of Quilmes, R. Saenz Peña 352, Bernal, B1876BXD, Buenos Aires, Argentina

    Juan Garona, Natasha T. Sobol & Daniel F. Alonso

  2. National Council of Scientific and Technical Research (CONICET), Buenos Aires, Argentina

    Juan Garona & Daniel F. Alonso

Authors
  1. Juan Garona
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  2. Natasha T. Sobol
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  3. Daniel F. Alonso
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Contributions

All authors equally contributed to the preparation of this manuscript.

Corresponding author

Correspondence to Daniel F. Alonso.

Ethics declarations

Studies NCT01606072 and NCT01623206 were approved by the ethics commitee at each site and by the National Administration of Drugs, Food and Medical Technology (ANMAT) in Argentina.

Grant Support

J. Garona is recipient of a postdoctoral fellowship from CONICET (Argentina). N.T. Sobol is recipient of an undergraduate fellowship from the Scientific Research Commission (CIC, Argentina). This work was supported by the grants UNQ 53/1029, PICT 1772/13, and INC 16-18 to D.F. Alonso.

Additional information

Letter to the editor in response to “Allogenic Blood Transfusion Is an Independent Predictor of Poorer Peri-operative Outcomes and Reduced Long-Term Survival after Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: a Review of 936 Cases” by Dr. Saxena and colleagues, published in the August issue of the Journal of Gastrointestinal Surgery.

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Garona, J., Sobol, N.T. & Alonso, D.F. Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy in Colorectal Cancer: Potential use of Perioperative Desmopressin to Reduce Allogenic Blood Transfusion Rates. J Gastrointest Surg 21, 1971–1973 (2017). https://doi.org/10.1007/s11605-017-3551-6

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  • DOI: https://doi.org/10.1007/s11605-017-3551-6

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