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Reflux-Associated Oxygen Desaturations: Usefulness in Diagnosing Reflux-Related Respiratory Symptoms

Journal of Gastrointestinal Surgery volume 17, pages 30–38 (2013)Cite this article

Abstract

Background

Current diagnostic techniques establishing gastroesophageal reflux disease as the underlying cause in patients with respiratory symptoms are poor. Our aim was to provide additional support to our prior studies suggesting that the association between reflux events and oxygen desaturations may be a useful discriminatory test in patients presenting with primary respiratory symptoms suspected of having gastroesophageal reflux as the etiology.

Methods

Thirty-seven patients with respiratory symptoms, 26 with typical symptoms, and 40 control subjects underwent simultaneous 24-h impedance–pH and pulse oximetry monitoring. Eight patients returned for post-fundoplication studies.

Results

The median number (interquartile range) of distal reflux events associated with oxygen desaturation was greater in patients with respiratory symptoms (17 (9–23)) than those with typical symptoms (7 (4–11, p < 0.001)) or control subjects (3 (2–6, p < 0.001)). A similar relationship was found for the number of proximal reflux-associated desaturations. Repeat study in seven post-fundoplication patients showed marked improvement, with reflux-associated desaturations approaching those of control subjects in five patients; 20 (9–20) distal preoperative versus 3 (0–5, p = 0.06) postoperative; similar results were identified proximally.

Conclusions

These data provide further proof that reflux-associated oxygen desaturations may discriminate patients presenting with primary respiratory symptoms as being due to reflux and may respond to antireflux surgery.

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Affiliations

  1. Division of Thoracic and Foregut Surgery, Department of Surgery, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box SURG, Rochester, NY, 14642, USA

    Candice L. Wilshire, Renato Salvador, Boris Sepesi, Stefan Niebisch, Thomas J. Watson, Virginia R. Litle, Christian G. Peyre, Carolyn E. Jones & Jeffrey H. Peters

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  1. Candice L. Wilshire
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  2. Renato Salvador
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  3. Boris Sepesi
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  4. Stefan Niebisch
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  5. Thomas J. Watson
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  6. Virginia R. Litle
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  7. Christian G. Peyre
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  8. Carolyn E. Jones
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  9. Jeffrey H. Peters
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Corresponding author

Correspondence to Jeffrey H. Peters.

Additional information

Digestive Disease Week 2012

The Society for Surgery of the Alimentary Tract Plenary Session

San Diego, California, 21 May 2012

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Wilshire, C.L., Salvador, R., Sepesi, B. et al. Reflux-Associated Oxygen Desaturations: Usefulness in Diagnosing Reflux-Related Respiratory Symptoms. J Gastrointest Surg 17, 30–38 (2013). https://doi.org/10.1007/s11605-012-2065-5

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  • DOI: https://doi.org/10.1007/s11605-012-2065-5

Keywords

  • GERD
  • Respiratory symptoms
  • Oxygen desaturation
  • Pulse oximetry
  • Reflux-associated oxygen desaturations