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Current Strategies and Future Perspectives for Intraperitoneal Adhesion Prevention

  • Review Article
  • Published:
Journal of Gastrointestinal Surgery

Abstract

Introduction

The formation of peritoneal adhesions still is a relevant clinical problem after abdominal surgery. Until today, the most important clinical strategies for adhesion prevention are accurate surgical technique and the physical separation of traumatized serosal areas. Despite a variety of barriers which are available in clinical use, the optimal material has not yet been found.

Discussion

Mesothelial cells play a crucial physiological role in frictionless gliding of the serosa and the maintenance of an antiadhesive surface. The formation of postoperative adhesions results from a cascade of events and is regulated by various cellular and humoral factors. Therefore, optimization or functionalization of barrier materials by developments interacting with this cascade on a structural or pharmacological level could give an innovative input for future strategies in peritoneal adhesion prevention. For this purpose, the proper understanding of the formal pathogenesis of adhesion formation is essential. Based on the physiology of the serosa and the pathophysiology of adhesion formation, the available barriers in current clinical practice as well as new innovations are discussed in the present review.

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Acknowledgments

We thank Ms. Kirsten Leistenschneider for the excellent support in graphic design.

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Correspondence to Christoph Brochhausen.

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Christoph Brochhausen and Volker H. Schmitt contributed equally to this work.

This manuscript contains parts of the MD thesis of V.H. Schmitt and C.N.E. Planck

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Brochhausen, C., Schmitt, V.H., Planck, C.N.E. et al. Current Strategies and Future Perspectives for Intraperitoneal Adhesion Prevention. J Gastrointest Surg 16, 1256–1274 (2012). https://doi.org/10.1007/s11605-011-1819-9

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