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An Extrahepatic Bile Duct Grafting Using a Bioabsorbable Polymer Tube

  • Original Article
  • Published:
Journal of Gastrointestinal Surgery Aims and scope

Abstract

Background

Thus far, no ideal substitutions have been developed for completely replacing the extrahepatic bile duct (EHBD).

Methods

We used a bioabsorbable polymer tube (BAPT) for the complete reconstruction of an EHBD in pigs. A 2-cm-long EHBD was resected from the duodenal side, and a 4-cm-long BAPT graft was implanted at that site. The animals were re-laparotomized at 1 or 4 months after the grafting; subsequently, gross, histological, and blood chemical studies were performed.

Results

At 1 month after grafting, tubular structure was observed in all resected specimens, and the lumen of the graft site had remnants of degraded BAPT. Gross examination at 4 months after grafting revealed that the BAPT had been completely absorbed, and the graft site was indistinguishable from the native extrahepatic bile duct. The lengths of the graft region at 4 months were 70% of the replaced BAPT. Simultaneously performed histological examination revealed the growth of a neo-bile duct at the graft site, with an epithelium identical to that of the native bile duct.

Conclusion

The BAPT graft implanted in this study completely replaced the EHBD defect. Hence, BAPT has the potential for application as a novel treatment modality for hepatobiliary diseases.

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Conflicts of Interest

We do not have any financial interests to disclose in this study.

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Authors and Affiliations

  1. Gastrointestinal Center, Department of Surgery, Saitama Medical University, International Medical Center, 1397-1 Yamane, Hidaka, Saitama, 350-1298, Japan

    Masayasu Aikawa, Mitsuo Miyazawa, Kojun Okamoto, Yasuko Toshimitsu, Katsuya Okada, Naoe Akimoto, Yosuke Ueno & Isamu Koyama

  2. Division of Life Science, Nara Medical University, Nara, Japan

    Yoshito Ikada

Authors
  1. Masayasu Aikawa
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  2. Mitsuo Miyazawa
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  3. Kojun Okamoto
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  4. Yasuko Toshimitsu
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  5. Katsuya Okada
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  6. Naoe Akimoto
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  7. Yosuke Ueno
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  8. Isamu Koyama
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  9. Yoshito Ikada
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Correspondence to Mitsuo Miyazawa.

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Aikawa, M., Miyazawa, M., Okamoto, K. et al. An Extrahepatic Bile Duct Grafting Using a Bioabsorbable Polymer Tube. J Gastrointest Surg 16, 529–534 (2012). https://doi.org/10.1007/s11605-011-1801-6

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  • DOI: https://doi.org/10.1007/s11605-011-1801-6

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